Tag: M.W:200-300

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Diazotization of 2,6-diaminobenzothiazole. A new process for the preparation of 2-chlorobenzothiazole reactive azo dyes, published in 1993, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Product Details of 2407-11-6.

The diazotization of 2,6-diaminobenzothiazole was studied. The two amino groups could be diazotized in HCl to yield a 2-chlorobenzothiazole-6-diazonium intermediate when reacted in a standard manner. A small comparative study on the diazotization of 6-substituted 2-aminobenzothiazoles using these standard conditions was presented. The usefulness of the reaction for the preparation of 2-chlorobenzothiazole reactive dyes was outlined.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of heterocyclic compounds of nitrogen. XXI. 2-Chloro-6-nitrobenzothiazole》. Authors are Takahashi, Torizo; Taniyama, Hyozo.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Safety of 2-Chloro-6-nitrobenzo[d]thiazole. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

The NO2 group in 1 isomer of nitro-2-mercaptobenzothiazole (I), obtained by the nitration of 2-mercaptobenzothiazole, was proved to be at the 6-position by the following method. I with PCl5 and POCl3 gave nitro-2-chlorobenzothiazole (II), yellow needles, m. 190-1°. 2-Amino-6-nitrobenzothiazole, yellow needles, m. 245°, was prepared from p-nitroaniline, (NH4)2SCN, and Br, diazotized and decomposed to 2-chloro-6-nitrobenzothiazole, yellow needles, m. 189-90°, identical with II; it can be concluded that I was 2-mercapto-6-nitrobenzothiazole. II can also be obtained by the nitration of 2-chlorobenzothiazole.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity, published in 2005-02-24, which mentions a compound: 23856-20-4, mainly applied to quinolinecarbonitrile arylamino preparation inhibitor HER2 EGFR kinase antitumor; quinoline cyano arylamino preparation inhibitor HER2 EGFR kinase antitumor; human epidermal growth factor receptor kinase inhibitor irreversible preparation, Electric Literature of C14H11N3O2.

A series of new 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles, e.g. I (R1 = H, Cl; R2 = PhCH2O, 1-imidazolyl, 2-furylmethoxy, etc.; R3 = Cl, CN, PhCH2O; R4 = Me, Et; R5 = Me, R6 = Me, HOCH2CH2; R5R6N = azetidinyl, piperidinyl, thiomorpholinyl, etc.) that function as irreversible inhibitors of human epidermal growth factor receptor-2 (HER-2) and epidermal growth factor receptor (EGFR) kinases have been prepared These compounds demonstrated enhanced activities for inhibiting HER-2 kinase and the growth of HER-2 pos. cells compared to the EGFR kinase inhibitor I [R1 = H; R2 = F; R3 = Cl; R4 = Et; R5 = R6 = Me; (EKB-569)]. Three synthetic routes were used to prepare these compounds They were prepared mostly by acylation of 6-amino-4-(arylamino)quinoline-3-carbonitriles with unsaturated acid chlorides or by amination of 4-chloro-6-(crotonamido)quinoline-3-carbonitriles with monocyclic or bicyclic anilines. The third route was developed to prepare a key intermediate, 6-acetamido-4-chloroquinoline-3-carbonitrile, that involved a safer cyclization step. It was shown that attaching a large lipophilic group at the para position of the 4-(arylamino) ring results in improved potency for inhibiting HER-2 kinase. The importance of a basic dialkylamino group at the end of the Michael acceptor for activity, due to intramol. catalysis of the Michael addition has also been demonstrated. This, along with improved water solubility, resulted in compounds with enhanced biol. properties. The mol. modeling results consistent with the proposed mechanism of inhibition are presented. Binding studies of one compound, I [R1 = H; R2 = 2-pyridylmethoxy; R3 = Cl; R4 = Et; R5 = R6 = Me; (HKI-272)] (C-14 radiolabeled), showed that it binds irreversibly to HER-2 protein in BT474 cells. Furthermore, it demonstrated excellent oral activity, especially in HER-2 overexpressing xenografts. Compound HKI-272 was selected for further studies and is currently in phase I clin. trials for the treatment of cancer.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Name: 2-Chloro-6-nitrobenzo[d]thiazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry. Author is Anderson, Zoe J.; Hobson, Christian; Needley, Rebecca; Song, Lijiang; Perryman, Michael S.; Kerby, Paul; Fox, David J..

A simple 1H and 13C NMR spectrometric anal. is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chem. shift and coupling constants of the signals associated with the proton and carbon at the α-stereocenter. This is applied to the estimation of epimerization during metal-free N-arylation and peptide coupling reactions.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bartoli, Giuseppe; Latrofa, Andrea; Todesco, Paolo E. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Category: ruthenium-catalysts.They published the article 《Experimental basis for a broadened Yukawa-Tsuno equation》 about this compound( cas:2407-11-6 ) in Gazzetta Chimica Italiana. Keywords: substituents Yukana Tsuno; Ingold Yukana Tsuno; free energy substituents. We’ll tell you more about this compound (cas:2407-11-6).

In systems having a series of electron-attracting or electron-donating substituents, the Ingold-Yukawa-Tsuno equation was applicable to the correlations of free energy with the substituent effect. The reactions between 4-ClC6H4NO2 and 2-chloro-6-nitrobenzothiazole and thiophene oxides substituted with some common meta and para substituents were examined

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Aminoluciferins as Functional Bioluminogenic Substrates of Firefly Luciferase, the main research direction is aminoluciferin bioluminogenic firefly luciferase.Related Products of 2407-11-6.

Firefly luciferase is widely used as a reporter gene in assays to study gene expression, gene delivery, and so on because of its extremely high signal-to-noise ratio. The availability of a range of bioluminogenic substrates would greatly extend the applicability of the luciferin-luciferase system. Herein, we describe a design concept for functional bioluminogenic substrates based on the aminoluciferin (AL) scaffold, together with a convenient, high-yield method for synthesizing N-alkylated ALs. We confirmed the usefulness of ALs as bioluminogenic substrates by synthesizing three probes. The first was a conjugate of AL with glutamate, Glu-AL. When Glu-AL, the first membrane-impermeable bioluminogenic substrate of luciferases, was applied to cells transfected with luciferase, luminescence was not observed; i.e., by using Glu-AL, we can distinguish between intracellular and extracellular events. The second was Cy5-AL, which consisted of Cy5, a near-IR (NIR) cyanine fluorescent dye, and AL, and emitted NIR light. When Cy5-AL reacted with luciferase, luminescence derived from Cy5 was observed as a result of bioluminescence resonance energy transfer (BRET) from AL to Cy5. The NIR emission wavelength would allow a signal to be observed from deeper tissues in bioluminescence in vivo imaging. The third was biotin-DEVD-AL (DEVD=the amino acid sequence Asp-Glu-Val-Asp), which employed a caspase-3 substrate peptide as a switch to control the accessibility of the substrate to luciferase, and could detect the activity of caspase-3 in a time-dependent manner. This generalized design strategy should be applicable to other proteases. Our results indicate that the AL scaffold is appropriate for a range of functional luminophores and represents a useful alternative substrate to luciferin.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C14H11N3O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Relation between structure and the antiinflammatory and analgesic activities of some aminoindazole derivatives. Author is Granger, Robert; Koeberle, J.; Le-Hao-Dong; Boucard, M.; Giroux, J. J.; Mizoule, J.; Yavordios, D..

Of the 12 aminoindazole derivatives studied, the 5-aminoindazoles had the highest antiinflammatory activity in rats with induced edema, and analgesic activity in mice. 1-Benzoyl-5-aminoindazole-HCl, the most interesting of the compounds studied, had a 50% effective dose of 100 mg/kg and 125 mg/kg in rats with Carrageenin-induced edema and kaolin-induced edema, resp. The hydrochloride (100 mg/kg/day, for 11 days) inhibited in vivo granuloma growth by 32%. In the rat, the antipyretic activity was equal to ∼40% of the activity obtained with an equal dose of acetylsalicyclic acid.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzothiazole. I. Nitration and bromination of 2-chlorobenzothiazole》. Authors are Colonna, Martino.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).SDS of cas: 2407-11-6. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

According to the hypothesis of Bonino (C.A. 34, 323.6) direct “”cationoid”” substitution (halogenation, nitration, etc.) of benzothiazole (I) should be directed toward the positions of the H atoms statistically pos., i. e., 4 or 6, while “”anionoid”” substitution (e. g., with NaNH2, NH2OH, etc.) should be directed toward the positions of the H atom statistically neg., i. e., 2. In order to test these predictions, 2-chlorobenzothiazole (II) was prepared (cf. Ger. pat. 516,996 (C.A. 25, 3015)) by the action of PCl5 and POCl3 on 2-mercaptobenzothiazole (III). II dissolved in concentrated H2SO4, treated with EtNO3 at 0°, gives a crystalline precipitate of 2-chloro-6-nitrobenzothiazole (IV), m. 192°, which at 140° (under pressure) with alc. NH3 gives 2-amino-6-nitrobenzothiazole (V), yellow, m. 245° (alc.), identical with the compound obtained by treating p-nitro-aniline with NH4CNS (cf. Kauffmann, C.A. 29, 2660.1). IV with Br in CHCl3 gives 2-chloro-6-bromobenzothiazole, white, m. 100-1°, and the same compound is obtained by treating the diazo derivative of IV with Cu2Br2. The structure of I according to Bonino shows the pyridine-like character of the N atom, and the strictly aromatic character of the benzene nucleus; however, in this nucleus the tricentered bond is fixed, while in other nuclei it is of an oscillating type, as in the equilibrium of quinoline: (VI)⇌ (VII).

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application of 2407-11-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Characterization of the reactivity of luciferin boronate – A probe for inflammatory oxidants with improved stability.

Boronate derivatives of luciferin, containing oxidant-activated self-immolative moieties, recently have been developed for bioluminescent detection of hydrogen peroxide in animal models. Here, the authors report the synthesis and characterization of luciferin boronic acid pinacol ester (LBE) as a probe for detection of hydrogen peroxide, hypochlorous acid, and peroxynitrite, with improved stability and response time. HPLC analyses showed that LBE quickly hydrolyzes in phosphate buffer to luciferin boronic acid (LBA). Hydrogen peroxide oxidizes LBA slowly, with the formation of luciferase substrate, luciferin (Luc-OH), as the only product. Hypochlorite also oxidizes LBA to luciferin, but the subsequent reaction of Luc-OH with hypochlorite gives a chlorinated luciferin Luc-OH-Cl, which has a higher fluorescence quantum yield than luciferin at pH 7.4 and is also a substrate for luciferase (Takakura H, et. all. ChemBioChem 2012; 13:1424). Similar to other boronate probes, LBA is oxidized by peroxynitrite in two pathways. Luc-OH is the product of the major pathway, common for all the oxidants tested, whereas the non-fluorescent nitrated derivative, Luc-NO2, is formed in the minor pathway, specific for peroxynitrite. Formation of luciferin radical intermediate in the minor pathway has been confirmed by EPR spin trapping and mass spectrometric analyses of the spin adducts. LBE shows potential as an improved probe for the detection of inflammatory oxidants in biol. settings. Complementation of the bioluminescence measurements by HPLC or LC-MS-based identification of chlorinated and nitrated luciferin(s) will help identify the oxidants detected.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Robust Light Emission from Cyclic Alkylaminoluciferin Substrates for Firefly Luciferase, published in 2010-10-06, which mentions a compound: 2407-11-6, mainly applied to emission cyclic alkylaminoluciferin substrate firefly luciferase, COA of Formula: C7H3ClN2O2S.

Firefly luciferase utilizes the chem. energy of ATP and oxygen to convert its substrate, D-luciferin, into an excited-state oxyluciferin mol. Relaxation of this mol. to the ground state is responsible for the yellow-green light emission. Synthetic cyclic alkylaminoluciferins that allow robust red-shifted light emission with the modified luciferase Ultra-Glo are described. Overall light emission is higher than that of acyclic alkylaminoluciferins, aminoluciferin, and the native substrate D-luciferin.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI