Tag: M.W:200-300

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemospecific and ligand free CuI catalyzed heterogeneous N-arylation of amines with diheteroaryl halides at room temperature, published in 2011-03-07, which mentions a compound: 2407-11-6, mainly applied to aliphatic amine heteroaryl halide copper chemospecific arylation; heteroaryl amine preparation; copper chemospecific arylation catalyst, Computed Properties of C7H3ClN2O2S.

A ligand free, copper-catalyzed N-arylation reaction of amines with diheteroaryl halides in heterogeneous medium at room temperature has been developed. The protocol is very effective for low boiling amines and useful for amines available in aqueous solution The reaction gives chemospecific arylation of amines with diheteroaryl halides in the mixture monoheteroaryl halides, diheteroaryl halides and carbocyclic aryl halides. The reaction is also chemospecific with respect to arylation of aliphatic amines. Monoarylated piperazines were also synthesized at room temperature following this protocol.

This literature about this compound(2407-11-6)Computed Properties of C7H3ClN2O2Shas given us a lot of inspiration, and I hope that the research on this compound(2-Chloro-6-nitrobenzo[d]thiazole) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Product Details of 676448-17-2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about 11-Step Total Synthesis of Teleocidins B-1-B-4. Author is Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S..

A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. Indolactam V, the known biosynthetic precursor to this family, was accessed through electrochem. amination, Cu-mediated aziridine opening, and a remarkable base-induced macrolactamization. Guided by a desire to minimize concession steps, the tactical combination of C-H borylation and a Sigman-Heck transform enabled the convergent, stereocontrolled synthesis of the teleocidins.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Verma, Sanjeev K.; Ghorpade, Ramarao; Kaushik, M. P. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Safety of 2-Chloro-6-nitrobenzo[d]thiazole.They published the article 《Arylation of Amines and Monoarylation of Symmetrical Diamines in the Presence of Brine Solution with Diheteroaryl Halides》 about this compound( cas:2407-11-6 ) in Synthetic Communications. Keywords: arylamine preparation; monoaryldiamine preparation; amine aryl halide arylation phase transfer catalyst. We’ll tell you more about this compound (cas:2407-11-6).

A simple, scalable, ligand-free, and metal-free protocol for arylation of amines and monoarylation of sym. diamines with diheteroaryl halides in the presence of brine solution has been developed. The protocol has broad structural applicability for chemoselective monoarylation of a wide variety of sym., cyclic, and acyclic aliphatic diamines. The protocol is also applicable for selective arylation of aliphatic amine in the presence of aromatic amine.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogen effect on the nucleophilic reactivity of 2-halobenzothiazoles》. Authors are Todesco, P. E.; Vivarelli, P..The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Synthetic Route of C7H3ClN2O2S. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

The rate of the substitution reactions of 2-chloro- (I), 2-bromo-(II), 2-fluoro- (III), 2-chloro-6-nitro- (IV), and 2-bromo-6-nitrobenzothiazole (V) with MeONa (VI) and PhSNa (VII) was calculated at 25° as K × 103. Thus, I and VI had K = 0.55 and similarly: I + VII, 0.20; II + VI, 0.41; II + VII, 0.44; III + VI, 550; III + VII, ≥1000; IV + VI, 278; IV + VII, 1660; V + VI, 152; V + VII, 2550. The results obtained showed that the reaction rates of 2-chloro and 2-bromo derivatives are similar but markedly lower than that of 2-fluoro derivatives In the case of the 2 halo-6-nitro derivatives, VII seemed more nucleophilic than VI.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Safety of 2-Chloro-6-nitrobenzo[d]thiazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis. Author is Delmas, Florence; Di Giorgio, Carole; Robin, Maxime; Azas, Nadine; Gasquet, Monique; Detang, Claire; Costa, Muriel; Timon-David, Pierre; Galy, Jean-Pierre.

6-Nitro- and 6-amino-benzothiazoles bearing different chains in position 2 and their corresponding anthranilic acid derivatives were investigated for their in vitro antiparasitic properties against parasites of the species Leishmania infantum and Trichomonas vaginalis compared to their toxicity towards human monocytes. Biol. investigations established that the antiprotozoal properties depended greatly on the chem. structure of the position 2 substitution-bearing group. Compound C1, 2-[(2-chloro-benzothiazol-6-yl) amino] benzoic acid, demonstrated an interesting antiproliferative activity towards parasites of the species T. vaginalis, while compound C11, 2-({2-[(2-hydroxyethyl) amino]-benzothiazol-6-yl} amino) benzoic acid, exhibited a promising activity against parasites of the species L. infantum in their intracellular amastigote form. Addnl. experiments established that compound C11, which was poorly toxic against the promastigote and the extracellular amastigote forms of the parasite, could improve host-protective mechanisms against Leishmania by preventing parasite internalization by macrophages and stimulating NO production, by a mechanism synergistically enhanced by the presence of gamma interferon.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloro-6-nitrobenzo[d]thiazole)Safety of 2-Chloro-6-nitrobenzo[d]thiazole, illustrating the importance and wide applicability of this compound(2407-11-6).

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Synthetic Route of C7H3ClN2O2S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Synthesis and characterization of N-substituted phenyl-N’-(2- chlorobenzothiazol-6-yl)urea.

Seven compounds of N-(R-phenyl)-N’-(2-chlorobenzothiaxol-6- yl)urea I (R = H, m-Cl, p-Cl, m-Me, p-Me, m-NO2, or p-NO2) were synthesized in 5 steps via condensation of 2-chloro-6-aminobenzothiazole and substituted Ph isocyanate with over all yield 74-88%. The structures of the synthetic compounds were characterized by elemental anal., 1HNMR, and IR.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloro-6-nitrobenzo[d]thiazole)Synthetic Route of C7H3ClN2O2S, illustrating the importance and wide applicability of this compound(2407-11-6).

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Electric Literature of C13H14BrNO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about Synthesis of the Bicyclic Welwitindolinone Core via an Alkylation/Cyclization Cascade Reaction. Author is Brailsford, John A.; Lauchli, Ryan; Shea, Kenneth J..

Synthesis of an advanced welwitindolinone intermediate (I) via an alkylation/cyclization reaction is reported. The key step involves a one pot Lewis acid-mediated alkylation of a silylketene aminal with a furan alc. followed by an intramol. cyclization. The reaction is stereoselective and takes place at low temperature The cycloadduct was highly functionalized and contains the welwitindolinone core structure.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23856-20-4, is researched, SMILESS is C(C1=CC=CC=C1)[N]3C2=CC=C(C=C2C=N3)[N+](=O)[O-], Molecular C14H11N3O2Journal, Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk called Relation between the electronic structure and the radioprotectant activity of some indazoles, Author is Sokolov, Yu. A., the main research direction is electronic structure radioprotectant indazole derivative.Electric Literature of C14H11N3O2.

Quantum chem. MNDO study of electronic structure for 29 indazoles has been performed. Statistically significant relation between some characteristics obtained and radioprotective activity was found out. Indazole structures which data predicted for radioprotective activity (survival, %) are on 50% level or more are proposed.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Electric Literature of C24H40N4O4Rh2. The article 《Synthesis of a few substituted 3-mercapto-s-triazolo[3,4-b]benzothiazoles》 in relation to this compound, is published in Journal of the Indian Chemical Society. Let’s take a look at the latest research on this compound (cas:2407-11-6).

The benzothiazole I (R = NH2, R1 = NO2) underwent Sandmeyer reaction and the resultant I (R = Cl, R1 = NO2) was treated with H2NNH2.H2O to give I (R = H2NNH, R1 = NO2), which was cyclized with CS2 and the product triazolobenzothiazole II (R1 = NO2, R2 = H) treated with EtI to give II (R1 = NO2, R2 = Et). II (R1 = Cl; R2 = Et, Me) were similarly prepared II had antitumor activity (no data).

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about Palladium-catalyzed cross-couplings of lithium arylzincates with aromatic halides: synthesis of analogues of isomeridianin G and evaluation as GSK-3β inhibitors, the main research direction is isomeridianin preparation GSK inhibition; Palladium catalyzed cross coupling lithium arylzincate aromatic halide.Name: 1-Boc-4-Bromoindole.

Several analogs of isomeridianin G have been synthesized using palladium-catalyzed cross-coupling reactions of lithium triorganozincates as a key step. The latter have been prepared by deprotonative lithiation followed by transmetalation using ZnCl2·TMEDA (0.33 equiv). Finally, the isomeridianin G analogs have been tested for their inhibition of GSK-3β and their IC50 values have been greatly improved over isomeridianin G.

There are many compounds similar to this compound(676448-17-2)Name: 1-Boc-4-Bromoindole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI