Tag: M.W:200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists, Author is Moriya, Minoru; Kishino, Hiroyuki; Sakuraba, Shunji; Sakamoto, Toshihiro; Suga, Takuya; Takahashi, Hidekazu; Suzuki, Takao; Ito, Masahiko; Ito, Junko; Moriya, Ryuichi; Takenaga, Norihiro; Iwaasa, Hisashi; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro, which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Safety of 2-Chloro-6-nitrobenzo[d]thiazole.

A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modification of the 2- and 5-positions led to improvement in potency and intrinsic clearance. Compound 25 (I) exhibited good plasma and brain exposure, and attenuated MCH induced food intake at 30 mg/kg PO in rats.

As far as I know, this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Application of 15418-29-8. The article 《Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole》 in relation to this compound, is published in Beilstein Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:2407-11-6).

2-Cyanobenzothiazoles (CBTs) were the useful building blocks for luciferin derivatives, for bioluminescent imaging, handles and for bioorthogonal ligations. An economical and scalable synthesis of 6-amino-2-cyanobenzothiazole based on a cyanation catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) was presented and its advantages for scale-up over previously reported routes was also discussed.

As far as I know, this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Aminoalkyl esters of thiazolecarboxylic acids. III. 2-Amino-6-benzothiazolecarboxylic acid, published in 1950, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Electric Literature of C7H3ClN2O2S.

cf. C.A. 46, 3533c, 10150h. To 12g. 2-benzothiazolecarboxylic acid in 30 ml. concentrated H2SO4 was slowly added 9 ml. HNO3 (d. 1.35) at room temperature, the mixture kept 12 hrs. at room temperature, poured on ice, and the crude product washed with H2O, dried, taken up in concentrated H2SO4, and precipitated with H2O (ice cooling necessary), yielded 85% 6-nitro-2-benzothiazolecarboxylic acid (I) yellow, decompose 115°; Ba salt, yellow needles, does not m. 300°; NH4 salt, yellow, m. 210°; Ag salt, colorless. Heating I with absolute EtOH and concentrated H2SO4 to 50-5° gave 40% 6-nitrobenzothiazole. I heated with SOCl2 to 60-70° formed a substance, m. 187-8°, containing Cl that is unattacked by refluxing with EtOH or MeOH and identified as 2-chloro-6-nitrobenzothiazole. I and PCl5 behave similarly. Heating 13.6 g. p-H2NC6H4CO2CH2CH2NEt2HCl in 50 ml. EtOH with a triturated mixture of 13.5 g. CuCl2 and 7.6 g. NH4CNS 15 min. at 60°, and adding 40 ml. dilute HCl gave a precipitate, which was extracted repeatedly with hot H2O and the extract neutralized with NH4OH, yielding 43% 2-diethylaminoethyl 2-amino-6-benzothiazolecarboxylate, m. 155° (from EtOH); HCl salt, m. 193-4° (from EtOH). Similarly, 6.1 g. p-H2NC6H4CO2(CH2)3NEt2HCl in 50 ml. EtOH treated with 3 ml. 30% alc. HCl, 6.5 g. CuCl2, and 3.6 g. NH4CNS gave 3.7 g. 3-diethylaminopropyl 2-amino-6-benzothiazolecarboxylate, m. 146° (from dilute EtOH). Similarly was formed 60% piperidinoethyl ester, m. 186°.

As far as I know, this compound(2407-11-6)Electric Literature of C7H3ClN2O2S can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2407-11-6, is researched, Molecular C7H3ClN2O2S, about Glycosyl 6-nitro-2-benzothiazoate. A highly efficient donor for β-stereoselective glycosylation, the main research direction is glycosyl nitro benzothiazoate donor stereoselective glycosylation; oligosaccharide preparation stereoselective glycosylation.Computed Properties of C7H3ClN2O2S.

Highly β-stereoselective glycosylations of glycosyl acceptors having a primary hydroxyl group by using a novel glycosyl donor, α-glycosyl 6-nitro-2-benzothiazoate (I), proceeded smoothly in the presence of a catalytic amount of trifluoromethanesulfonic acid (TfOH) in CH2Cl2 at -78°C to afford the corresponding glycosides in high yields. I gave β-saccharides more dominantly compared with those using other α-glycosyl donors such as thioform- and trichloroacetimidates or fluoride under the same conditions.

As far as I know, this compound(2407-11-6)Computed Properties of C7H3ClN2O2S can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Application of 15418-29-8. The article 《Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole》 in relation to this compound, is published in Beilstein Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:2407-11-6).

2-Cyanobenzothiazoles (CBTs) were the useful building blocks for luciferin derivatives, for bioluminescent imaging, handles and for bioorthogonal ligations. An economical and scalable synthesis of 6-amino-2-cyanobenzothiazole based on a cyanation catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) was presented and its advantages for scale-up over previously reported routes was also discussed.

As far as I know, this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Aminoalkyl esters of thiazolecarboxylic acids. III. 2-Amino-6-benzothiazolecarboxylic acid, published in 1950, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Electric Literature of C7H3ClN2O2S.

cf. C.A. 46, 3533c, 10150h. To 12g. 2-benzothiazolecarboxylic acid in 30 ml. concentrated H2SO4 was slowly added 9 ml. HNO3 (d. 1.35) at room temperature, the mixture kept 12 hrs. at room temperature, poured on ice, and the crude product washed with H2O, dried, taken up in concentrated H2SO4, and precipitated with H2O (ice cooling necessary), yielded 85% 6-nitro-2-benzothiazolecarboxylic acid (I) yellow, decompose 115°; Ba salt, yellow needles, does not m. 300°; NH4 salt, yellow, m. 210°; Ag salt, colorless. Heating I with absolute EtOH and concentrated H2SO4 to 50-5° gave 40% 6-nitrobenzothiazole. I heated with SOCl2 to 60-70° formed a substance, m. 187-8°, containing Cl that is unattacked by refluxing with EtOH or MeOH and identified as 2-chloro-6-nitrobenzothiazole. I and PCl5 behave similarly. Heating 13.6 g. p-H2NC6H4CO2CH2CH2NEt2HCl in 50 ml. EtOH with a triturated mixture of 13.5 g. CuCl2 and 7.6 g. NH4CNS 15 min. at 60°, and adding 40 ml. dilute HCl gave a precipitate, which was extracted repeatedly with hot H2O and the extract neutralized with NH4OH, yielding 43% 2-diethylaminoethyl 2-amino-6-benzothiazolecarboxylate, m. 155° (from EtOH); HCl salt, m. 193-4° (from EtOH). Similarly, 6.1 g. p-H2NC6H4CO2(CH2)3NEt2HCl in 50 ml. EtOH treated with 3 ml. 30% alc. HCl, 6.5 g. CuCl2, and 3.6 g. NH4CNS gave 3.7 g. 3-diethylaminopropyl 2-amino-6-benzothiazolecarboxylate, m. 146° (from dilute EtOH). Similarly was formed 60% piperidinoethyl ester, m. 186°.

As far as I know, this compound(2407-11-6)Electric Literature of C7H3ClN2O2S can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Derivatives of benzothiazole. II. Obtaining 2-chlorobenzothiazole and some of its derivatives, published in 1937, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole.

cf. C. A. 32, 160.5. Nitration of 2-mercaptobenzothiazole (I) gives 70% of 6-nitro-2-mercaptobenzothiazole, m. 226°. Reduction of this with H2S gives 75% of the corresponding amine, m. 260-1° and this, by diazotization and treatment with Cu2Cl2 and HCl gives 6-chloro-2-mercaptobenzothiazole (II), m. 244-5°. In an analogous way the 6-I derivative, m. 233-4°, is obtained. By diazotization of 2-aminobenzothiazole, 25% of 2-chlorobenzothiazole (III) is obtained, but if I is heated with PCl5 in POCl3 or PSCl3 at 100° until no more HCl is evolved, 55% of III, b. 248°, is obtained. At the same time a small amount of dibenzothiazolyl 2,2′-monosulfide (IV), m. 106°, is obtained. If the reaction temperature is raised, more IV and less III are formed. Nitration of IV gives a mixture of 6-nitro- and 6,6′-dinitrodibenzothiazolyl 2,2′-monosulfides, m. 142° and 281-2°, resp. Higher nitration temperature favors formation of the dinitro compound Nitration of III gives 83% of 6-nitro-2-chlorobenzothiazole, m. 192°. The same compound is obtained from 6-nitrobenzothiazolyl 2,2′-monosulfide and PCl5, but only in 5% yield. A poor yield of product is also obtained when II is treated with PCl5. Thus, side reactions occur to a very great extent when PCl5 reacts with derivatives of 2-mercaptobenzothiazole.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.Computed Properties of C7H3ClN2O2S.

A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (I), was developed for Cu sensing in biol. system. I offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biol. system was demonstrated in cell culture.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Application In Synthesis of 1,2-Benzisoxazole. The article 《Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:2407-11-6).

We report herein a new site-specific microarray immobilization method based on a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole (CBT). This immobilization strategy has been successfully applied to anchor small mols., peptides and proteins onto microarrays.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Safety of 1-Boc-4-Bromoindole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about Using Chlorotrifluoroethane for Trifluoroethylation of (Hetero)aryl Bromides and Chlorides via Nickel Catalysis.

A nickel-catalyzed reductive cross-coupling between industrial chem. CF3CH2Cl and (hetero)aryl bromides and chlorides was reported. The reaction was synthetically simple without the preparation of arylmetals and exhibits high functional group tolerance. The utility of this protocol was demonstrated by the late-stage modification of pharmaceuticals, providing a facile route for medicinal chem.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI