Tag: M.W:200-300

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hesp, Kevin D.; Lundgren, Rylan J.; Stradiotto, Mark researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Safety of 1-Boc-4-Bromoindole.They published the article 《Palladium-Catalyzed Mono-α-arylation of Acetone with Aryl Halides and Tosylates》 about this compound( cas:676448-17-2 ) in Journal of the American Chemical Society. Keywords: aryl methyl ketone preparation; arylhalide acetone monoarylation palladium catalyst. We’ll tell you more about this compound (cas:676448-17-2).

The first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates is reported. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs2CO3 as the base and employing acetone as both a reagent and the solvent.

Although many compounds look similar to this compound(676448-17-2)Safety of 1-Boc-4-Bromoindole, numerous studies have shown that this compound(SMILES:C(C)(C)(C)OC(=O)[N]2C1=CC=CC(=C1C=C2)Br), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Bao; You, Qi Dong; Li, Zhi Yu researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).COA of Formula: C7H3ClN2O2S.They published the article 《Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives》 about this compound( cas:2407-11-6 ) in Chinese Chemical Letters. Keywords: quinolinecarbonitrile preparation antitumor neoplasm. We’ll tell you more about this compound (cas:2407-11-6).

Twelve new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitriles I (R1 = H2N, Me2N, Et2N; R2 = Et2N, N-piperidinyl, N-morpholinyl, etc.) were synthesized. The cytotoxicity of the new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. Several synthesized compounds displayed more potent cytotoxic activities than Bosutinib. Compound I (R1 = R2 = Et2N) exhibited the most potent antitumor activity among the tested compounds

After consulting a lot of data, we found that this compound(2407-11-6)COA of Formula: C7H3ClN2O2S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application In Synthesis of 1-Benzyl-5-nitro-1H-indazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Author is Milik, Sandra N.; Abdel-Aziz, Amal Kamal; Lasheen, Deena S.; Serya, Rabah A. T.; Minucci, Saverio; Abouzid, Khaled A. M..

In light of the emergence of resistance against the currently available EGFR inhibitors, our study focuses on tackling this problem through the development of dual EGFR/HER2 inhibitors with improved enzymic affinities. Guided by the binding mode of the marketed dual EGFR/HER2 inhibitor, Lapatinib, we proposed the design of dual EGFR/HER2 inhibitors based on the 6-phenylthieno[2,3-d]pyrimidine as a core scaffold and hinge binder. After two cycles of screening aiming to identify the optimum aniline headgroup and solubilizing group, we eventually identified 27b as a dual EGFR/HER2 inhibitor with IC50 values of 91.7 nM and 1.2 μM, resp. Notably, 27b dramatically reduced the viability of various patient-derived cancer cells preferentially overexpressing EGFR/HER2 (A431, MDA-MBA-361 and SKBr3 with IC50 values of 1.45, 3.5 and 4.83 μM, resp.). Addnl., 27b efficiently thwarted the proliferation of lapatinib-resistant human non-small lung carcinoma (NCI-H1975) cells, harboring T790 M mutation, with IC50 of 4.2 μM. Consistently, 27b significantly blocked EGF-induced EGFR activation and inactivated its downstream AKT/mTOR/S6 signalling pathway triggering apoptotic cell death in NCI-H1975 cells. The present study presents a promising candidate for further design and development of novel EGFR/HER2 inhibitors capable of overcoming EGFR TKIs resistance.

Although many compounds look similar to this compound(23856-20-4)Application In Synthesis of 1-Benzyl-5-nitro-1H-indazole, numerous studies have shown that this compound(SMILES:C(C1=CC=CC=C1)[N]3C2=CC=C(C=C2C=N3)[N+](=O)[O-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

McCorvy, John D.; Butler, Kyle V.; Kelly, Brendan; Rechsteiner, Katie; Karpiak, Joel; Betz, Robin M.; Kormos, Bethany L.; Shoichet, Brian K.; Dror, Ron O.; Jin, Jian; Roth, Bryan L. published the article 《Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs》. Keywords: indole aripiprazole preparation beta arrestin ligand GPCR dopamine receptor.They researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Reference of 1-Boc-4-Bromoindole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:676448-17-2) here.

Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a promising approach for current drug discovery. Although structure-based drug design of biased agonists remains challenging even with an abundance of GPCR crystal structures, the authors present an approach for translating GPCR structural data into β-arrestin-biased ligands for aminergic GPCRs. The authors identified specific amino acid-ligand contacts at transmembrane helix 5 (TM5) and extracellular loop 2 (EL2) responsible for Gi/o and β-arrestin signaling, resp., and targeted those residues to develop biased ligands. For these ligands, the authors found that bias is conserved at other aminergic GPCRs that retain similar residues at TM5 and EL2. The authors’ approach provides a template for generating arrestin-biased ligands by modifying predicted ligand interactions that block TM5 interactions and promote EL2 interactions. This strategy may facilitate the structure-guided design of arrestin-biased ligands at other GPCRs, including polypharmacol. biased ligands.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Pubbl. ist. chim. univ. Bologna called Benzothiazole. V. The mobility of the chlorine atom in 2-chloro-6-nitrobenzothiazole, Author is Colonna, M.; Andrisano, R., which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Computed Properties of C7H3ClN2O2S.

The mobility of the Cl atom in IV is greater than that of Cl in II, and probably it is influenced by the presence of the NO2 group in position 6. The following reactions take place very easily and with nearly theoretical yields. IV, treated with PhNH2, gives 2-anilino-6-nitrobenzothiazole, C13H9N3O2S, yellow crystals, m. 247° (cf. Hoffmann, Ber. 13, 12(1880)); with NH2NH2, the 2-hydrazino derivative C7H6N4O2S, yellow needles, m. 243-4° (decomposition) (benzaldehyde hydrazone, C14H10N4O2S, yellow needles (from dioxane), m. 275°; acetophenone hydrazone, C15H12N4O2S, yellow prisms (from dioxane), m. 266° (partial decomposition); tetrazole derivative, C7H3N5O2S, yellow plates becoming brown in the light and decomposing 158°); with piperidine, the 2-piperidyl derivative, C12H13N3O2S, lemon-yellow needles (from EtOH), m. 170°; with p-aminobiphenyl, the 2-(p-biphenylylamino) derivative, C19H13N3O2S, orange precipitate, m. 165°; with p-anisidine the 2-(p-anisidino) derivative, C14H11N3O2S, yellow needles (from dioxane), m. 282°, with p-phenetidine, the 2-(p-phenetidino) derivative, C15H13N3O2S, yellow needles (from dioxane), m. 235°.

Although many compounds look similar to this compound(2407-11-6)Computed Properties of C7H3ClN2O2S, numerous studies have shown that this compound(SMILES:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C14H11N3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives. Author is Zhang, Fan; Zhai, Xin; Chen, Li-Juan; Qi, Jian-Guo; Cui, Bo; Gu, Yu-Cheng; Gong, Ping.

2,5-Disubstituted pyrimido[5,4-c]quinolines were synthesized, and their cytotoxic activity against H460, HT-29, and MDA-MB-231 cell lines was evaluated in vitro. Most of the tested compounds showed stronger activity to the selected cell lines than ZM447439.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Zhou, Jiao-Long; Ye, Meng-Chun; Sun, Xiu-Li; Tang, Yong published the article 《Trisoxazoline/Cu(II)-catalyzed asymmetric intramolecular Friedel-Crafts alkylation reaction of indoles》. Keywords: indole preparation triisopropyl borate substitution benzyl bromide coupling; indolyl alkylidene malonate preparation chiral trisoxazoline copper; asym intramol Friedel Crafts alkylation fused benzocarbazole stereoselective preparation; intramol asym Friedel Crafts alkylation catalyst chiral trisoxazoline copper.They researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Electric Literature of C13H14BrNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:676448-17-2) here.

Intramol. Friedel-Crafts alkylation reaction of indoles catalyzed by trisoxazoline/copper(II) is described. This annulation provides an easy access to polycyclic indole derivatives, e.g., I, with up to 90% ee in up to 99% yield.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Zhuo, Junming; Zhang, Yong; Li, Zijian; Li, Chao published the article 《Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles》. Keywords: ketone preparation; acylimidazole preparation aryl alkyl bromide acylation nickel catalyst; carboxylic acid carbonyldiimidazole cross coupling.They researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Synthetic Route of C13H14BrNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:676448-17-2) here.

A modular method for the acylation of aryl and alkyl halides RBr (R = Ph, 2-methoxypyrimidin-5-yl, furan-3-yl, etc.) was reported. The transformation relies on acylimidazoles I (R1 = Ph, 2,2-dimethylpropyl, cyclopentylmethyl, naphthalen-2-yl, oxan-4-yl, etc.) and easy-to-prepare and flexible species derived from abundant carboxylic acids R1COOH as viable cross-coupling partners for the Ni-catalyzed acylation. Careful examination revealed a remarkable mechanism: the amide C-N bond of primary and secondary imidazolides I (R1 = pent-4-en-1-yl, cyclooct-4-en-1-yl, cyclopropylmethyl, etc.) can be activated by single-electron reduction, representing a major departure from other reported amide C-N bond activation reactions. Extensive mechanistic studies also revealed an intriguing CO-extrusion-recombination phenomenon. This cross-coupling reaction between two electrophiles features a broad substrate scope bearing a wide gamut of functionalities. The practicality of this atypical transformation was demonstrated in the synthesis of II (R2 = H, acetyl) and 1-(furan-3-yl)-4-methylpentan-1-one, which are difficult to access using traditional organometallic chem.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application In Synthesis of 2-Chloro-6-nitrobenzo[d]thiazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Effective induction of β-selectivity using α- or β-mannosyl 6-nitro-2-benzothiazoate in mannosylation. Author is Hashihayata, Takashi; Mukaiyama, Teruaki.

Highly β-selective mannosylations of glycosyl acceptors with an α-mannosyl 6-nitro-2-benzothiazoate donor (I) were carried out smoothly in the presence of a catalytic amount of tetrakis(pentafluorophenyl)boric acid [HB(C6F5)4] to afford the corresponding disaccharides in good to high yields: it was proved that high β-selectivity was entirely dependent on the characteristic properties of a donor I and a catalyst, HB(C6F5)4. Interestingly, it was observed that in situ anomerization from 1β to 1α took place rapidly when β-mannosyl donor was treated with a catalytic amount of HB(C6F5)4 in CH2Cl2.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Recommanded Product: 1-Benzyl-5-nitro-1H-indazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor. Author is Wheeler, Rob C.; Baxter, Emma; Campbell, Ian B.; MacDonald, Simon J. F..

Flow chem. is a rapidly emerging technol. within the pharmaceutical industry, both within medicinal and development chem. groups. The advantages of flow chem., increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technol. in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilizes flow chem. to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogs.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI