Tag: M.W:200-300

Computed Properties of C7H3ClN2O2S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition. Author is Garzon, Miguel; Arce, Elsa M.; Reddy, Raju Jannapu; Davies, Paul W..

A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl-imidazole family of heteroaromatics was developed. New types of heteroatom substituted carbimidoyl nitrenoids were efficiently realized from robust, bench-stable N-(heteroaryl)-pyridinium-N-aminides by formal gold-catalyzed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allowed rapid access into diverse functionalized scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

The article 《General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition》 also mentions many details about this compound(2407-11-6)Computed Properties of C7H3ClN2O2S, you can pay attention to it, because details determine success or failure

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Forlani, Luciano; Todesco, Paolo E. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Safety of 2-Chloro-6-nitrobenzo[d]thiazole.They published the article 《Base catalysis in reactions between 2-halo-6-nitrobenzothiazoles and aliphatic amines in benzene. Part II》 about this compound( cas:2407-11-6 ) in Gazzetta Chimica Italiana. Keywords: benzothiazole halonitro amine substitution; substitution halonitrobenzothiazole amine catalysis. We’ll tell you more about this compound (cas:2407-11-6).

Rate data for reactions of I (X = Br, Cl) with amines (e.g. piperidine, BuNH2, Me3CNH2) show the presence of a base-catalyzed pathway which involves bifunctional catalysis, basic on the entering group, acidic on the leaving group.

The article 《Base catalysis in reactions between 2-halo-6-nitrobenzothiazoles and aliphatic amines in benzene. Part II》 also mentions many details about this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole, you can pay attention to it, because details determine success or failure

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C13H14BrNO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about Chemoselective, scalable nickel-electrocatalytic O-arylation of alcohols.

The formation of aryl-alkyl ether bonds through cross coupling of alcs. with aryl halides represents a useful strategic departure from classical SN2 methods. Numerous tactics relying on Pd-, Cu-, and Ni-based catalytic systems have emerged over the past several years. Herein we disclose a Ni-catalyzed electrochem. driven protocol to achieve this useful transformation with a broad substrate scope in an operationally simple way. This electrochem. method does not require strong base, exogenous expensive transition metal catalysts (e.g.Ir, Ru), and can easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibits an enhanced substrate scope over the mechanistically related photochem. variant as it tolerates tertiary amine functional groups in the alc. nucleophile.

The article 《Chemoselective, scalable nickel-electrocatalytic O-arylation of alcohols》 also mentions many details about this compound(676448-17-2)Formula: C13H14BrNO2, you can pay attention to it, because details determine success or failure

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

SDS of cas: 2407-11-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Synthesis and tautomerism of O-heteryl derivatives of tropolone. Author is Kurbatov, S. V.; Budarina, Z. N.; Zhdanov, Yu. A.; Olekhnovich, L. P..

Trimethyltropolone O-heteryl derivatives I (R = 6-nitro-2-benzothiazolyl, 5-nitro-2-pyrimidinyl, or 4,6-dichloro-1,3,5-triazin-2-yl) were prepared and O ⇄ O’ migration of the heteryl R groups studied by temperature-dependent NMR. Migration capabilities of the R groups increased in their stated order.

After consulting a lot of data, we found that this compound(2407-11-6)SDS of cas: 2407-11-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry.Formula: C14H11N3O2.

Potassium fluoride-impregnated on alumina catalyzes a solvent-free regioselective O-benzylation, benzoylation and cinnamylation of phenols. Reaction proceeds simply by triturating together equivalent amounts of phenol and corresponding halide in the presence of 5 mol% of KF/alumina for 5-20 min with a mortar and pestle, without need for any additive, such as a phase-transfer catalyst or solvent. Key features of the protocol include its efficiency also for solid-solid precursors and regioselectivity for phenolic hydroxyl groups vs. alc. hydroxy groups. Utility of the protocol for N- and S-benzylation has also been explored. Products were obtained in excellent yields and the catalyst can be easily recycled several times without significant loss of activity. The synthesis of the target compounds was achieved using 5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-2-methyl-4H-1-benzopyran-4-one (chromene alkaloid rohitukine) was a starting material. The title compounds thus formed included benzyl ethers, such as a rohitukine methoxybenzyl ether (I).

After consulting a lot of data, we found that this compound(23856-20-4)Formula: C14H11N3O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Xu, Han; Hu, Xu-hong; Zou, Xiao-mao; Zhu, You-quan; Liu, Bin; Hu, Fang-zhong; Yang, Hua-zheng published the article 《Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-substituted-l-(3-trifluoromethyl)phenyl-1H-pyrazole》. Keywords: herbicide pyrazole benzoxazole benzothiazole pyrimidine preparation phytoene desaturase.They researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Category: ruthenium-catalysts. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2407-11-6) here.

The authors synthesized a series of novel 5-heterocycloxy-3-substituted-1-[(3-trifluoromethyl)phenyl]-1H-pyrazole derivatives The herbicidal activity of two intermediate compounds and thirteen target compounds were evaluated against Brassica napus and Echinochloa crus-galli (L.) Beauv tests. Bioassay results show that some of the compounds exhibit better inhibiting activities against Brassica napus and some of the compounds exhibit bleaching activities against Echinochloa crus-galli (L.) Beauv at 100 μg/mL. The title compounds thus formed included a [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]benzoxazole derivative (I) and related substances, such as [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]benzothiazole derivatives and [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]pyrimidine derivatives The synthesis of the target compounds was achieved using 2,4-dihydro-5-methyl-2-[3-(trifluoromethyl)phenyl]-3H-pyrazol-3-one and 2,4-dihydro-5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]-3H-pyrazol-3-one (and its enol isomer) as key intermediates.

After consulting a lot of data, we found that this compound(2407-11-6)Category: ruthenium-catalysts can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.Safety of 2-Chloro-6-nitrobenzo[d]thiazole.

With the aim to develop new chem. tools based on simplified natural metabolites to help deciphering the mol. mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Compounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein. This article reports the design, synthesis and biol. evaluation of a series of 2-aminobenzazoles on the necroptotic cell death through the inhibition of RIPK1 protein kinase. The 2-aminobenzimidazole and 2-aminobenzothiazole platforms presented herein can serve as novel chem. tools to study the mol. regulation of necroptosis and further develop lead drug candidates for chronic pathologies involving necroptosis.

After consulting a lot of data, we found that this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organic Chemistry called Reactions in the thiazole series. I. Reactions of 2-chlorobenzothiazoles with thioureas, Author is Scott, Winfield; Watt, George W., which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Product Details of 2407-11-6.

N-Methylenecyclohexylamine, melted on the water bath and treated with S in small portions, gives 37% of s-dicyclohexylthiourea (I), m. 179-80°; various modifications of the reaction did not materially increase the yield (maximum, 44%). The reaction of 1,1′-methylenebispiperidine and S in xylene did not give the expected s-dipentamethylenethiourea but there resulted 34% of piperidine pentamethylenedithiocarbamate, m. 172-3°, piperidine hydrosulfide, H2S and varying amounts of tarry products. The reaction of 2-chlorobenzothiazole (II) with thiourea, the allyl, Ph and o-tolyl derivatives gave 100, 100, 78 and 79%, resp., of 2-mercaptobenzothiazole (III); no reaction occurred with s-diphenyl- N,N-dimethyl-N’-phenyl-(IV), N,N-pentamethylene-N’-phenyl derivatives and I. II and N,N’-o-phenylenethiourea give the addition compound, C14H10ClN3S2, m. 233-4° (decomposition), in 86% yield when refluxed 1 hr. in EtOH. The yield of the 6-NO2 derivative of III, m. 225-7°, from the 6-NO2 derivative of II was: thiourea 100, allyl- 94, Ph-92, o-tolyl 93, s-di-Pr 49, I 94°, IV 0. A by-product in the reaction with IV is 2-dimethylamino-6-nitrobenzothiazole, m. 197.5-9°; Me2NH is probably formed by the decomposition of IV. The order of decreasing reactivity is thiourea > mono- > di- > trisubstituted.

Although many compounds look similar to this compound(2407-11-6)Product Details of 2407-11-6, numerous studies have shown that this compound(SMILES:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Related Products of 676448-17-2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Boc-4-Bromoindole, is researched, Molecular C13H14BrNO2, CAS is 676448-17-2, about Metallaphotoredox-enabled deoxygenative arylation of alcohols. Author is Dong, Zhe; MacMillan, David W. C..

Metal-catalyzed cross-couplings are a mainstay of organic synthesis and are widely used for the formation of C-C bonds, particularly in the production of unsaturated scaffolds1. However, alkyl cross-couplings using native sp3-hybridized functional groups such as alcs. remain relatively underdeveloped2. In particular, a robust and general method for the direct deoxygenative coupling of alcs. would have major implications for the field of organic synthesis. A general method for the direct deoxygenative cross-coupling of free alcs. must overcome several challenges, most notably the in situ cleavage of strong C-O bonds3, but would allow access to the vast collection of com. available, structurally diverse alcs. as coupling partners4. Authors report herein a metallaphotoredox-based cross-coupling platform in which free alcs. are activated in situ by N-heterocyclic carbene salts for carbon-carbon bond formation with aryl halide coupling partners. This method is mild, robust, selective and most importantly, capable of accommodating a wide range of primary, secondary and tertiary alcs. as well as pharmaceutically relevant aryl and heteroaryl bromides and chlorides. The power of the transformation has been demonstrated in a number of complex settings, including the late-stage functionalization of Taxol and a modular synthesis of Januvia, an antidiabetic medication. This technol. represents a general strategy for the merger of in situ alc. activation with transition metal catalysis.

Although many compounds look similar to this compound(676448-17-2)Related Products of 676448-17-2, numerous studies have shown that this compound(SMILES:C(C)(C)(C)OC(=O)[N]2C1=CC=CC(=C1C=C2)Br), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents, published in 2005-07-15, which mentions a compound: 2407-11-6, mainly applied to benzothiazolediamine preparation antitumor, Application of 2407-11-6.

Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid [2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide, which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (I) was designed and synthesized as a biol. stable derivative containing no nitro group. The highly potent derivative I exhibited excellent in vivo inhibitory effect on tumor growth.

Although many compounds look similar to this compound(2407-11-6)Application of 2407-11-6, numerous studies have shown that this compound(SMILES:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI