The important role of 10049-08-8

With the complex challenges of chemical substances, we look forward to future research findings about Ruthenium(III) chloride

Name is Ruthenium(III) chloride, as a common heterocyclic compound, it belongs to ruthenium-catalysts compound, and cas is 10049-08-8, its synthesis route is as follows.,10049-08-8

Example 13 Synthesis of (3S)-3-(1,3-benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic Acid Step One: To a solution of 3-benzylpyridine (1.65 g, 9.77 mmol) in acetone (3.5 mL), 1-chloro-2,4-dinitrobenzene (2.00 g, 9.56 mmol) was added and the mixture was refluxed overnight. The mixture was cooled to room temperature, diluted with acetone and the solvent was decanted from the precipitate. The crude solid was washed with acetone (2 times) and diethyl ether (1 time), decanting each time to give 37(3.57 g, 100percent) as a gray solid. Step Two: To a solution of 1-amino-1-hydroxymethylcyclohexane (0.45 g, 3.5 mmol) in n-butanol (8.75 mL), solid N-(2,4-dintrophenyl)-3-benzylpyridinum chloride (37, 1.23 g, 3.3 mmol) was added. The resulting solution was heated to reflux for 2.5 days under a nitrogen atmosphere. The mixture was cooled, diluted with water and filtered. The filtrate was basified with concentrated NH4OH (2 mL) and extracted with ethyl acetate. The aqueous layer was concentrated to dryness to give 38(0.56 g) as a yellow oil which was used without further purification. Step Three: To a solution of crude 38(0.56 g, 3.5 mmol theoretical) in water (10 mL), a solution of potassium ferricyanide (3.3 g, 10 mmol) in water (15 mL) was added dropwise via an addition funnel over 30 minutes at 0¡ã C. A solution of KOH (0.76 g, 13.5 mmol) in water (5 mL) was then added over 30 minutes. Toluene (10 mL) was added and the solution was stirred for one hour at 0¡ã C. The layers were separated, and the aqueous layer was extracted again with toluene. The combined extracts were dried over Na2SO4 and filtered and the filtrate was concentrated under reduced pressure. The residue was chromatographed on silica gel, eluding with 7:13 hexanes:ethyl acetate to give 39(20 mg, 1.9percent, two steps.) Step Four: To a suspension of 39(20 mg, 0.068 mmol) in aqueous KOH (1M, 0.70 mL) potassium persulfate (0.073 g, 0.270 mmol) and ruthenium (III) chloride (1 mg, catalytic) and THF (0.25 mL) were added. The mixture was stirred for 1 hour and extracted with dichloromethane. The aqueous layer was acidified and extracted with ethyl acetate (3 times). The ethyl acetate extracts were combined, dried over MgSO4 and filtered. The filtrate was concentrated under reduced pressure to give 40(0.0148 g, 70percent) as a tan solid. (3S)-3-(1,3-Benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic acid was prepared from 40according to the procedures described in Example 1. 1H NMR (400 MHz, CD3SO2CD3): delta 1.40 (m, 4H), 1.68 (m, 2H), 2.04 (m, 2H), 2.60 (d, J=7.0 Hz, 2H), 3.67 (d, J=15.2 Hz, 1H), 3.72 (d, J=15.2 Hz, 1H), 5.12 (m, 1H), 5.95 (m, 2H), 6.19 (t, J=7.0 Hz, 1H), 6.74 (dd, J=7.8, 1.4 Hz, 1H), 6.76 (d, J=7.8 Hz, 1H), 6.90 (d, J=1.4 Hz, 1H), 7.10 (d, J=5.8 Hz, 1H), 7.20 (m, 5H), 7.57 (d, J=8.4Hz, 1H), 7.66 (dd, J=7.7, 1.8 Hz, 1H).

With the complex challenges of chemical substances, we look forward to future research findings about Ruthenium(III) chloride

Reference£º
Patent; Biediger, Ronald J.; Dupre, Brian; Hamaker, Linda K.; Holland, George W.; Kassir, Jamal M.; Li, Wen; Market, Robert V.; Nguyen, Noel; Scott, Ian L.; Wu, Chengde; Decker, E. Radford; US2003/199692; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The important role of 10049-08-8

With the complex challenges of chemical substances, we look forward to future research findings about Ruthenium(III) chloride

Name is Ruthenium(III) chloride, as a common heterocyclic compound, it belongs to ruthenium-catalysts compound, and cas is 10049-08-8, its synthesis route is as follows.,10049-08-8

[(1S,3R)-1-(Methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid ((1S,3R)-1-Benzyl-3-methyl-cyclopentylmethyl)-carbamic acid methyl ester (2.6 g, 9.9 mmol) and sodium periodate (29.8 g, 140 mmol) were stirred together in carbon tetrachloride (30 mL), acetonitrile (30 mL), and water for 6 hours. The mixture was cooled to 0¡ã C., and ruthenium(III) chloride (0.04 g, 0.2 mmol) was added to the reaction mixture. The reaction was allowed to warm to room temperature and stirred for 20 hours. Diethyl ether (50 mL) was added, and the mixture was then extracted with saturated aqueous sodium hydrogen carbonate (200 mL). The aqueous layer was acidified to pH 1 with 4N hydrochloric acid and re-extracted with ethyl acetate (200 mL), dried (MgSO4), and the solvent was evaporated under reduced pressure. The residue was purified by chromatography (silica gel, eluding with a gradient of heptane to 1:1 heptane:ethyl acetate) to give 0.32 g (14percent) of [(1S,3R)-1-(methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid; Rf (heptane-ethyl acetate, 8:2) 0.30; IR thin film (cm-1) 3338 (NH), 1712 (C=O); 1H-NMR (400 MHz; CDCl3): delta 9.29 (1H, s, COOH), 5.17 (1H, bs, NH), 3.71 (3H, s, OMe), 3.30 (1H, dd, J 14.4, 7.1, CHAHBNH2), 3.17 (1H, dd, J 14.4, 6.6, CHAHBNH2), 2.37 (2H, s, CH2COOH), 2.20-1.00 (7H, m), 1.01 (3H, d, J 6.4, CHMe); MS (ES+) m/z 230 (M+H, 63percent), 481 (M+Na,100).

With the complex challenges of chemical substances, we look forward to future research findings about Ruthenium(III) chloride

Reference£º
Patent; Bryans, Justin Stephen; Blakemore, David Clive; Williams, Sophie Caroline; US2003/69438; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of 10049-08-8

As the paragraph descriping shows that 10049-08-8 is playing an increasingly important role.

10049-08-8, Ruthenium(III) chloride is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10049-08-8

Example 13 Synthesis of (3S)-3-(1,3-benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic Acid Step One: To a solution of 3-benzylpyridine (1.65 g, 9.77 mmol) in acetone (3.5 mL), 1-chloro-2,4-dinitrobenzene (2.00 g, 9.56 mmol) was added and the mixture was refluxed overnight. The mixture was cooled to room temperature, diluted with acetone and the solvent was decanted from the precipitate. The crude solid was washed with acetone (2 times) and diethyl ether (1 time), decanting each time to give 37(3.57 g, 100percent) as a gray solid. Step Two: To a solution of 1-amino-1-hydroxymethylcyclohexane (0.45 g, 3.5 mmol) in n-butanol (8.75 mL), solid N-(2,4-dintrophenyl)-3-benzylpyridinum chloride (37, 1.23 g, 3.3 mmol) was added. The resulting solution was heated to reflux for 2.5 days under a nitrogen atmosphere. The mixture was cooled, diluted with water and filtered. The filtrate was basified with concentrated NH4OH (2 mL) and extracted with ethyl acetate. The aqueous layer was concentrated to dryness to give 38(0.56 g) as a yellow oil which was used without further purification. Step Three: To a solution of crude 38(0.56 g, 3.5 mmol theoretical) in water (10 mL), a solution of potassium ferricyanide (3.3 g, 10 mmol) in water (15 mL) was added dropwise via an addition funnel over 30 minutes at 0¡ã C. A solution of KOH (0.76 g, 13.5 mmol) in water (5 mL) was then added over 30 minutes. Toluene (10 mL) was added and the solution was stirred for one hour at 0¡ã C. The layers were separated, and the aqueous layer was extracted again with toluene. The combined extracts were dried over Na2SO4 and filtered and the filtrate was concentrated under reduced pressure. The residue was chromatographed on silica gel, eluding with 7:13 hexanes:ethyl acetate to give 39(20 mg, 1.9percent, two steps.) Step Four: To a suspension of 39(20 mg, 0.068 mmol) in aqueous KOH (1M, 0.70 mL) potassium persulfate (0.073 g, 0.270 mmol) and ruthenium (III) chloride (1 mg, catalytic) and THF (0.25 mL) were added. The mixture was stirred for 1 hour and extracted with dichloromethane. The aqueous layer was acidified and extracted with ethyl acetate (3 times). The ethyl acetate extracts were combined, dried over MgSO4 and filtered. The filtrate was concentrated under reduced pressure to give 40(0.0148 g, 70percent) as a tan solid. (3S)-3-(1,3-Benzodioxol-5-yl)-3-[({1-[2-oxo-3-(phenylmethyl)-1(2H)-pyridinyl]cyclohexyl}carbonyl)amino]propanoic acid was prepared from 40according to the procedures described in Example 1. 1H NMR (400 MHz, CD3SO2CD3): delta 1.40 (m, 4H), 1.68 (m, 2H), 2.04 (m, 2H), 2.60 (d, J=7.0 Hz, 2H), 3.67 (d, J=15.2 Hz, 1H), 3.72 (d, J=15.2 Hz, 1H), 5.12 (m, 1H), 5.95 (m, 2H), 6.19 (t, J=7.0 Hz, 1H), 6.74 (dd, J=7.8, 1.4 Hz, 1H), 6.76 (d, J=7.8 Hz, 1H), 6.90 (d, J=1.4 Hz, 1H), 7.10 (d, J=5.8 Hz, 1H), 7.20 (m, 5H), 7.57 (d, J=8.4Hz, 1H), 7.66 (dd, J=7.7, 1.8 Hz, 1H).

As the paragraph descriping shows that 10049-08-8 is playing an increasingly important role.

Reference£º
Patent; Biediger, Ronald J.; Dupre, Brian; Hamaker, Linda K.; Holland, George W.; Kassir, Jamal M.; Li, Wen; Market, Robert V.; Nguyen, Noel; Scott, Ian L.; Wu, Chengde; Decker, E. Radford; US2003/199692; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application of 1,3-Bisbenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid

As the rapid development of chemical substances, we look forward to future research findings about 10049-08-8

The ruthenium-catalysts compound, name is Ruthenium(III) chloride,cas is 10049-08-8, mainly used in chemical industry, its synthesis route is as follows.

Step 1 To a solution of 2-(4,4-dimethyl-chroman-7-yl)-heptan-1-ol (0.27 g, 0.98 mmole, from Example 1, step 6) in a mixture of 2 mL of carbon tetrachloride, 2 mL acetonitrile and 3 mL water, containing 3-5 mg of ruthenium chloride, was added 0.85 g of sodium periodate. The mixture was stirred at room temperature for 2 hours, diluted with 10 mL of water, and pH was adjusted to 2 with 10percent hydrochloric acid. The mixture was extracted with three 10 mL portions of dichloromethane. The organic phase was dried over MgSO4, filtered and concentrated in vacuo to give a dark oil. The product was purified by flash chromatography (SiO2, gradient from 0 to 20percent ethyl acetate in hexanes) to yield 0.16 g of 2-(4,4-dimethyl-chroman-7-yl)-heptanoic acid as a pale yellow oil.

As the rapid development of chemical substances, we look forward to future research findings about 10049-08-8

Reference£º
Patent; Syntex (U.S.A.) LLC; US2003/158178; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Downstream synthetic route of 10049-08-8

#N/A

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10049-08-8,Ruthenium(III) chloride,as a common compound, the synthetic route is as follows.

Step 1 To a solution of 2-(4,4-dimethyl-chroman-7-yl)-heptan-1-ol (0.27 g, 0.98 mmole, from Example 1, step 6) in a mixture of 2 mL of carbon tetrachloride, 2 mL acetonitrile and 3 mL water, containing 3-5 mg of ruthenium chloride, was added 0.85 g of sodium periodate. The mixture was stirred at room temperature for 2 hours, diluted with 10 mL of water, and pH was adjusted to 2 with 10percent hydrochloric acid. The mixture was extracted with three 10 mL portions of dichloromethane. The organic phase was dried over MgSO4, filtered and concentrated in vacuo to give a dark oil. The product was purified by flash chromatography (SiO2, gradient from 0 to 20percent ethyl acetate in hexanes) to yield 0.16 g of 2-(4,4-dimethyl-chroman-7-yl)-heptanoic acid as a pale yellow oil.

#N/A

Reference£º
Patent; Syntex (U.S.A.) LLC; US2003/158178; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Simple exploration of 10049-08-8

The synthetic route of 10049-08-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10049-08-8,Ruthenium(III) chloride,as a common compound, the synthetic route is as follows.

[(1S,3R)-1-(Methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid ((1S,3R)-1-Benzyl-3-methyl-cyclopentylmethyl)-carbamic acid methyl ester (2.6 g, 9.9 mmol) and sodium periodate (29.8 g, 140 mmol) were stirred together in carbon tetrachloride (30 mL), acetonitrile (30 mL), and water for 6 hours. The mixture was cooled to 0¡ã C., and ruthenium(III) chloride (0.04 g, 0.2 mmol) was added to the reaction mixture. The reaction was allowed to warm to room temperature and stirred for 20 hours. Diethyl ether (50 mL) was added, and the mixture was then extracted with saturated aqueous sodium hydrogen carbonate (200 mL). The aqueous layer was acidified to pH 1 with 4N hydrochloric acid and re-extracted with ethyl acetate (200 mL), dried (MgSO4), and the solvent was evaporated under reduced pressure. The residue was purified by chromatography (silica gel, eluding with a gradient of heptane to 1:1 heptane:ethyl acetate) to give 0.32 g (14percent) of [(1S,3R)-1-(methoxycarbonylamino-methyl)-3-methyl-cyclopentyl]-acetic acid; Rf (heptane-ethyl acetate, 8:2) 0.30; IR thin film (cm-1) 3338 (NH), 1712 (C=O); 1H-NMR (400 MHz; CDCl3): delta 9.29 (1H, s, COOH), 5.17 (1H, bs, NH), 3.71 (3H, s, OMe), 3.30 (1H, dd, J 14.4, 7.1, CHAHBNH2), 3.17 (1H, dd, J 14.4, 6.6, CHAHBNH2), 2.37 (2H, s, CH2COOH), 2.20-1.00 (7H, m), 1.01 (3H, d, J 6.4, CHMe); MS (ES+) m/z 230 (M+H, 63percent), 481 (M+Na,100).

The synthetic route of 10049-08-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bryans, Justin Stephen; Blakemore, David Clive; Williams, Sophie Caroline; US2003/69438; (2003); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI