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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Chemistry of the benz-α,β-isoxazoles》. Authors are Lindemann, Hans; Thiele, Hans.The article about the compound:1,2-Benzisoxazolecas:271-95-4,SMILESS:C12=CC=CC=C1ON=C2).Electric Literature of C7H5NO. Through the article, more information about this compound (cas:271-95-4) is conveyed.

5,2-O2N(Cl)C6H3CH:NOH in EtOH is unchanged by heating 0.25 hr. with aqueous AcON3 or with Ag2O; alkalies give yellow, salts which yield the oxime on acidifying; the oxime is also unchanged after heating in C5H5 or PhNO2, but, heated dry, decomposes violently. Heated with EtOH-KOH, it gives 2,5-HO(O2N)-C5H3CN (I), which also results from nitro-4-indoxazene and 10% NaOH or upon nitrating o-HOC6H4CN. Heating I above its m. p. for a short time gives 2,4,6-tri-[2-hydroxy-5-nitrophenyl]-l,3,5-triazine, yellow, m. above 340°; Ac2O and H2SO4 gradually dissolve it but no Ac derivative could be isolated. The corresponding 3,5-dibromo derivative, yellow, m. 355°, results from 3,5,2-Br2(HO)C6H2CN (II). 3,5-Dibromosalicylaldoxime (III), m. 218-20°; solution in warm Ac2O gives the mono-Ac derivative, m. 146°; heated above its m. p., it gives II; Ac2O and H2SO4, give the di-Ac derivative m. 150°. III, boiled with Ac2O for 2 hrs., gives 3,5-dibromo-2-acetoxybenzonitrile, m. 85-7°. 2-Hydroxybenzaldehyde acetyloxime, m. 75°; slowly heated to 120-30°, it splits off AcOH, giving indoxazene (IV), b14 82-3°, d421 1.1727, nD20 1.5570, MD 32.67; this is probably identical with the compound of Conduché (C. A. 2, 999) from o-HOC6H4CHO and H2NCONHOH. With 40% KOH, IV gives o-NCC6H4OK. 4-Nitro derivative, m. 126°; heated above its m. p., it gives 5,2-O2N(HO)C6H3CN. 2-Hydroxyacetophenoneaceloxime, m. 146°; heated at 160° it gives 2-methylindoxazene, b11 92.5°, d420 1.1247, nD20 1.5483, MD 37.68; 4-NO2 derivative, m. 128°; 4-NH2 derivative, m. 105° (Ac derivative, m. 156°); the diazo solution couples with β-C10H7OH to give a red azo dye. 3-Methyl-6-hydroxyacelophenone acetoxime, m. 114°; heated at 120° it gives 2,4-dimethylindoxazene, b13 116° d420 1.0949, nD20 1.5455, MD 42.45. NO2 derivative, pale yellow, m. 72°.

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Ferre, Yves; Faure, Robert; Vincent, Emile Jean published an article about the compound: 1,2-Benzisoxazole( cas:271-95-4,SMILESS:C12=CC=CC=C1ON=C2 ).COA of Formula: C7H5NO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:271-95-4) through the article.

The modified complete neglect of differential overlap-CI method proposed by Del Bene and Jaffe is used for the study of phys. properties of eight five-membered ring heterocycles containing one oxygen atom and one nitrogen atom at least. Theoretical results are in very good agreement with exptl. data for ground state properties (chem. reactivity approach, 1H and 13C NMR results, dipole moments, and ionization potentials) as for electronic absorption spectra.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 271-95-4, is researched, SMILESS is C12=CC=CC=C1ON=C2, Molecular C7H5NOJournal, Indian Drugs called Antituberculosis compounds. Part VII. Towards the design of novel antimycobacterial agents, Author is Kulkarni, Sheshgiri N.; Kamath, S. V.; Devasthale, S. V.; Hooper, M., the main research direction is antituberculosis compound thiourea benzisoxazole derivative.Quality Control of 1,2-Benzisoxazole.

A 3-dialkylamino-2-hydroxypropoxy side chain can be introduced into antituberculosis thioureas and 1,2-benzisoxazoles without much loss of activity. The resulting compounds have lower log P values (P = hydrophobic fragmental constant) which are thought to be important in the design of new compounds for the treatment of tuberculosis and leprosy.

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Hollfelder, Florian; Kirby, Anthony J.; Tawfik, Dan S. published the article 《Efficient Catalysis of Proton Transfer by Synzymes》. Keywords: catalysis proton transfer synzyme; synthetic enzyme proton transfer catalysis.They researched the compound: 1,2-Benzisoxazole( cas:271-95-4 ).Related Products of 271-95-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:271-95-4) here.

Enzyme catalysis depends on subtle combinations of effects that are difficult to sep. and quantify. Medium effects are a crucial part of this package, but the assignment of a local dielec. constant to the structured microenvironment of an active site and its effect on ground state destabilization or transition state stabilization by electrostatic interactions is exptl. impossible. We desire to mimic, and thus begin to quantify, such active site medium effects exptl. As a test reaction, we use the eliminative cleavage of benzisoxazole (Kemp elimination), known to be particularly sensitive to the effects of the medium. A subset of several hundred water-soluble polymers was prepared by alkylating polyethyleneimine (PEI) with different combination of three contrasting alkyl groups, forming enzyme-like catalysts (synzymes). These polymers catalyze the Kemp elimination, in water, with rate accelerations as high as 106 and at least 500 turnovers per basic site. Proton transfer from carbon is catalyzed by polymer amine groups with pKA values as low as 5.7 and apparent effective molarities of the order of 1000 M. Four of the synzymes combining high activity with sufficient solubility were selected for detailed characterization, including determination of kcat, KM, and pKA. The pH rate profile confirms that the catalytic species are active in their basic forms.

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Application of 271-95-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,2-Benzisoxazole, is researched, Molecular C7H5NO, CAS is 271-95-4, about Method development and validation of RP-HPLC method for determination of new antipsychotic agent in paliperidone palmitate bulk drug. Author is Swarnalatha, G.; Vijayakumar, B.; Jothieswari, D.; Reddy, P. Jaya Chandra; Mohankumar, M..

A simple, precise, rapid, reproducible, accurate and stability indicating RP-HPLC method has been developed for the determination of new antipsychotic agent paliperidone in pharmaceutical formulation. zorbax -SB-Ph, 150 × 4.6mm; 3.5μm particle size column was used with variable wavelength UV detector. The mobile phase consisting of PH 4 Buffer and Acetonitrile 80:20 volume/volume was used. The flow rate was 1 mL/min and the effluent was monitored at 238 nm. The retention time of drug was 0.9. The method was linear over the concentration range of 1.0 mg/mL. The method precision for the determination of assay was below 2%RSD. The percentage recovery of paliperidone was 85-115%. The validation of method was carried out utilizing ICH Q2 (R1) guidelines.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzisoxazoles. VI. Friedel-Crafts acylation of benzisoxazoles》. Authors are Borsche, Walther; Hahn-Weinheimer, Paula.The article about the compound:1,2-Benzisoxazolecas:271-95-4,SMILESS:C12=CC=CC=C1ON=C2).COA of Formula: C7H5NO. Through the article, more information about this compound (cas:271-95-4) is conveyed.

cf. C.A. 35, 4378.1. 1,2-Benzisoxazole (I) (2.38 g.) in 5 cc. PhNO2 (II) reacting 24 h. with 3 g. AlCl3 suspended in 6.5 cc. II and 2 g. AcCl, treated with ice and 2 cc. concentrated HCl, steam-distilled, and the still residue extracted with Et2O, followed by extraction with 0.2 N NaOH and acidification, gave (impure) 5,2-Ac(HO)C6H3CN (III); 2,4-dinitrophenylhydrazone, red needles, m. 300° (from AcOH). Pure III, m. 78° (after distillation in vacuo), was formed from ο-HOC6H4CN (IV) by a very similar acylation. III heated with Ac2O gave the 2-acetate, b2 156°; dinitrophenylhydrazone, red, m. 272° (from MeOH). I in II warmed with AlCl3 and treated with HCl gave IV. I in II and AlCl3 on standing also gave IV. The 3-Me derivative (V) of I was prepared either from 2-BrC6H4COCl (cf. Borsche and Scriba, C.A. 34, 761.2) or by Lindemann’s method (C.A. 21, 91) from 2-HOC6H4Ac (formed from IV and MeMgI). V on acylation in II gave very small yields of a 4(?)-Ac derivative of V (isolated as the red 2,4-dinitrophenylhydrazone, m. 254°) and, as the main product 5,2-Ac(HO)C6H3CMe:NOH, brown oil, characterized as the dinitrophenylhydrazone, red leaflets, m. 314° (from AcOH). The 3-Ph derivative of I remained unchanged under various conditions of acetylation. Evidently the aromatic nucleus of benzisoxazole is not readily affected by the Friedel-Crafts reaction and acylation is effective only after fission of the isoxazole ring. 2,3-HO(MeO)C6H3CH:NOH, m. 124°, with Ac2O gave the O-acetyl derivative, C10H11O4N, m. 99°, 19.22 g. of which when heated at 40-50° and 2 mm. lost AcOH, and when heated further at 140-150° (at 2 mm.) gave a mixture of 12.2 g. 2,3-HO(MeO)C6H3CN (VI), b2 172-8°, yellow, m. 59°, and about 10% of the 7-MeO derivative (VII) of I, yellow oil, b2 155-60°. Friedel-Crafts acetylation of 2.98 g. VII gave about 0.95 g. of the alkali-soluble 5,2,3-Ac(HO)2C6H2CN (VIII), yellow, m. 44° [2,4-dinitrophenylhydrazone (IX), red needles, m. 316°], and (in the alkali-insoluble portion) the 4(?)-Ac-derivative of VII, brown oil (2,4-dinitrophenylhydrazone, bright red, m. 233°). Acetylation of VII with Ac2O gave 53% VIII. A Friedel-Crafts benzoylation of VII in II gave (in the alkali-insoluble portion) 2,3-BzO(MeO)C6H3CN (X), m. 80° (giving no color with FeCl3 and failing to react with (O2N)2C6H3NHNH2), and (in the alkali-soluble part) 2,3-BzO(HO)C6H3CN, m. 95-6° (giving a blue color with FeCl3 in MeOH and yielding no dinitrophenylhydrazone), and converted into X on methylation. Friedel-Crafts phenacetylation of VII in II gave (23%) 2,3-PhCH2CO(MeO)C6H3CN, m. 49-50° (from MeOH), also formed from PhCH2COCl and VI. CH2N2 and VI gave 2,3-(MeO)2C6H3CN, b2 195°, m. 45°. Br in AcOH and VI gave the 5-Br derivative of VI, m. 171° (from glacial AcOH). Acetylation of VI, however, yielded VIII, m. 44° (identified as IX). Benzoylation of VI gave a mixture of X and 2,3-BzO(HO)C6H3CN. VI (14.9 g.) in Et2O with MeMgI (from 35.5 g. MeI and 6.1 g. Mg) gave about 90% 2,3-HO(MeO)C6H3Ac, m. 53° (from petr. ether) (dinitrophenythydrazone, yellow leaflets, m. 222°), whose oxime (5.43 g.), m. 125°, with 20 cc. Ac2O gave 3 g. 3-Me derivative (XI) of VII, b2 185-90°. Friedel-Crafts acetylation of XI gave the alkali-insoluble 4(?)-Ac derivative of XI (dinitrophenylhydrazone, red, m. 146°) and, in the alkali-soluble part, 5,2,3-Ac(HO)(MeO)C6H2C(:NOH)Me, whose 2,4-dinitrophenylhydrazone, red needles, m. 233°. Analogously PhMgBr and VI gave the 2,3-HO(MeO)C6H3Bz, m. 59°, b3 220-25° (2,4-dinitrophenylhydrazone, red, m. 226°), whose oxime, m. 221°, with Ac2O, gave the 3-Ph derivative (XII) of VII, b2 230-40°, m. 58°. 4-Br derivative of XII m. 150°; 4-NO2 derivative of XII, pale yellow, m. 194° (from CHCl3-MeOH). Friedel-Crafts acetylation of XII in II gave 79% of the 4(?)-Ac derivative, m. 187° (dinitrophenylhydrazone, dark red, m. 278°). BzCl and XII gave a Bz derivative, C21H15O3N (yielding no dinitrophenylhydrazone).

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Name: 1,2-Benzisoxazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1,2-Benzisoxazole, is researched, Molecular C7H5NO, CAS is 271-95-4, about Photochemistry of 1,2-benzisoxazoles in strongly acidic solution. Author is Doppler, Thomas; Schmid, Hans; Hansen, Hans Juergen.

Photolysis of I (R = R1 = H; R = Me, R1 = H; R = Me, R1 = 6-Me) in 96% H2SO4 yields mixtures of II ( R = R1 = H; R = Me, R1 = H; R = Me, R1 = 4-Me) and III (R = R1 = H; R = Me, R1 = H; R = Me, R1 = 4-Me). Photolysis of I (R = Me, R1 = 5-Me) in 96% H2SO4 yields III (R = Me, R1 = 5-Me) in only 6% yield. 1,2-Benzisoxazolium ions react in the excited singlet state by heterolytic cleavage of the N-O bond to yield the corresponding aryloxenium ion (IV) in the singlet state; reaction of IV and HSO4- ions yields, after hydrolysis, the dihydroxy compounds II and III.

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SDS of cas: 271-95-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1,2-Benzisoxazole, is researched, Molecular C7H5NO, CAS is 271-95-4, about Zonisamide as a Treatment for Partial Epileptic Seizures: A Systematic Review. Author is Cox, Joanna H.; Seri, Stefano; Cavanna, Andrea E..

A review. Although the majority of people with epilepsy have a good prognosis and their seizures can be well controlled with pharmacotherapy, up to one-third of patients can develop drug-resistant epilepsy, especially those patients with partial seizures. This unmet need has driven considerable efforts over the last few decades aimed at developing and testing newer antiepileptic agents to improve seizure control. One of the most promising antiepileptic drugs of the new generation is zonisamide, a benzisoxazole derivative chem. unrelated to other anticonvulsant agents. In this article, the authors present the results of a systematic literature review summarizing the current evidence on the efficacy and tolerability of zonisamide for the treatment of partial seizures. Of particular interest within this updated review are the recent data on the use of zonisamide as monotherapy, as they might open new therapeutic avenues.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1,2-Benzisoxazole, is researched, Molecular C7H5NO, CAS is 271-95-4, about Gold-Catalyzed Michael-Type Reactions and [4 + 2]-Annulations between Propiolates and 1,2-Benzisoxazoles with Ester-Directed Chemoselectivity, the main research direction is gold catalyzed Michael type reaction annulation propiolate benzisoxazole; ester directed chemoselective reaction Michael type product oxazinone preparation.Recommanded Product: 1,2-Benzisoxazole.

This work reports gold-catalyzed reactions between 1,2-benzisoxazoles and propiolate derivatives with ester-controlled chemoselectivity. For Et propiolates I(R = Ph, 4-BrPh, iPr, etc.; R’ = Et), their gold-catalyzed reactions afforded Michael-type products II (R = Ph, 4-BrPh, iPr, etc.), whereas tert-Bu propiolates I (R = Ph, 4-BrPh, iPr, etc.; R’ = tert-Bu) preferably underwent [4 + 2]-annulations, further yielding 6H-1,3-oxazin-6-one derivatives III (R = Ph, 4-BrPh, iPr, etc.).

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectral study of the nitrogen derivatives of some aromatic aldehydes and ketones. III. N-Alkyl- and N-acyl-arylaldoximes.》. Authors are Grammaticakis, Panos.The article about the compound:1,2-Benzisoxazolecas:271-95-4,SMILESS:C12=CC=CC=C1ON=C2).Application In Synthesis of 1,2-Benzisoxazole. Through the article, more information about this compound (cas:271-95-4) is conveyed.

The ultraviolet absorption spectra of the N-alkyl and the N-acyl derivatives of the arylaldoximes are determined in the region 3750 to 2150 A. in alc. or cyclohexane solutions at concentrations 0.01, 0.001 and 0.0001 N. These include the N-benzyloxime of (o,p) methylbenzaldehydes; (o,m,p) methoxybenzaldehydes; N-(α-phenylpropyl)benzaldoxime, N-(α-p-tolylpropyl)benzaldoxime; N-(α-p-methoxyphenylpropyl)benzaldoxime; N-acetylanisaldoxime; N-acetylbenzaldoxime; N-carbamylbenzaldoxime; N-carbamylanisaldoxime; N-acetylsalicylaldoxime; N-carbamylsalicylaldoxime; benzisoxazole. The chromophore of the N-substituted arylaldoximes is more absorbing than those of the aryl aldoximes and of their O-substituted derivatives The absorption curves of the N-acyl derivatives of the arylaldoximes are displaced toward the ultraviolet relative to those of the corresponding N-alkyl derivatives and toward the visible relative to those of the oximes. The preparation and purification of all the substances studied are given.

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