246047-72-3| Page 117 of 122 | Ruthenium catalysts

Brief introduction of 246047-72-3

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.

General procedure: To a Schlenk flask charged with Grubbs? catalyst 2 (0.42 g,0.50 mmol) and CuCl (0.05 g, 0.50 mmol), compound 14 (or 15, 16)(0.6 mmol) in 10 mL dry dichloromethane was added at room temperature under N2. The resulting mixture was stirred for 40 min at 40 C. After being cooled to room temperature, the reaction mixturewas filtered and the clear filtrate was collected. The solvent from the filtrate was evaporated under vacuum to give a residue. The residue was purified by silica gel chromatography (CH2Cl2:ethyl acetate 2:1 or pentanes: ethyl acetate 3:2 or 1:1) to givethe desired product as a green crystalline solid.

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

Reference£º
Article; Zhang, Yiran; Shao, Mingbo; Zhang, Huizhu; Li, Yuqing; Liu, Dongyu; Cheng, Yu; Liu, Guiyan; Wang, Jianhui; Journal of Organometallic Chemistry; vol. 756; (2014); p. 1 – 9;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium

With the synthetic route has been constantly updated, we look forward to future research findings about (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,belong ruthenium-catalysts compound

As a common heterocyclic compound, it belong ruthenium-catalysts compound,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,246047-72-3,Molecular formula: C46H65Cl2N2PRu,mainly used in chemical industry, its synthesis route is as follows.,246047-72-3

Downstream synthetic route of (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO482,mainly used in chemical industry, its synthesis route is as follows.,246047-72-3

Example 5 – Synthesis of the complex 4 according to the invention The commercially available complex G (200 mg, 0.24 mmol) was placed in a flask, to which methylene chloride was added (6 ml). This was followed by adding the compound of the formula: (78 mg, 0.47 mmol) and tricyclohexylphosphine (132 mg, 0.47 mmol). The resulting solution was stirred at a temperature of 40C for 1 hour. The reaction mixture was introduced at the top of a chromatographic column packed with silica gel (eluent: ethyl acetate/cyclohexane, 0 to 10 vol.%). After evaporating the solvents, the complex 4 was obtained as a brown solid (104 mg, 50% yield). 4 H NMR (500 MHz, CD2CI2) delta ppm: 16.42 (s, 1H), 8.00 (dd, J = 9.3, 2.7 Hz, 1H), 7.53 (d, J = 2.1 Hz, 1H), 7.12 (s, 1H), 7.06 (s, 2H), 6.69 (d, J = 9.3 Hz, 1H), 6.22 (s, 1H), 4.07- 4.03 (m, 1H), 3.88-3.77 (m, 2H), 3.73-3.67 (m, 1H) , 2.64 (s, 3H), 2.56 (s, 3H), 2.51 (s, 3H), 2.39 (s, 3H), 2.27 (s, 3H), 1.64-1.50 (m, 13H), 1.46 (m, 3H), 1.12-0.75 (m, 20H). 13C NMR: (125 MHz, CD2CI2) delta ppm: 282.23 (d), 220.27, 219.73, 184.63 (d), 145.82, 139.23 (d), 139.08, 138.89, 137.46, 136.76, 136.69, 134.24, 134.00, 130.55, 130.36, 129.41 (d), 125.78, 117.59, 115.27, 52.14 (d), 51.63 (d), 34.52, 32.77, 32.64, 29.40, 28.91, 28.00 (m), 26.90 (d), 22.73, 21.34, 21.01, 19.41, 18.63, 18.53, 17.10, 14.21.

Reference£º
Patent; APEIRON SYNTHESIS S.A.; SKOWERSKI, Krzysztof; BIENIEK, Micha?; WO2014/16422; (2014); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

New learning discoveries about 246047-72-3

246047-72-3 (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium 11147261, aruthenium-catalysts compound, is more and more widely used in various fields.

246047-72-3, (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium is a ruthenium-catalysts compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

After a 50 mL two-necked flask was purged with argon, the ligand 7k (10 mmol), CuCl (30 mmol, 3 eq) and 30 mL of dry DCM were successively added and the mixture was purged three times with argon to protect the closed system with an argon balloon. Ruthenium complex 1b (12 mmol) was added under argon atmosphere, and the reaction was carried out at room temperature for 0.5 hour. After completion of the reaction, silica gel was added to the filtrate after filtration, and the crude product was obtained by silica gel column chromatography, and then washed with methanol or pentane-DCM to obtain a green solid product 8k in a yield of 77%., 246047-72-3

Reference£º
Patent; Zannan Science And Technology (Shanghai) Co., Ltd.; Zhan Zhengyun; (102 pag.)CN104262403; (2017); B;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

New learning discoveries about 246047-72-3

(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, cas is 246047-72-3, it is a common heterocyclic compound, the ruthenium-catalysts compound, its synthesis route is as follows.,246047-72-3

Complex 1 (2.0 grams) was dissolved in toluene (10 mL), and 4-dimethylaminopyridine (1.18 grams, 4 mol equivalents) was added. The reaction flask was purged with argon and the reaction mixture was stirred for approximately 12 hours at about 20 C. to about 25 C. during which time a color change from dark purple to light green was observed. The reaction mixture was transferred into 75 mL of cold (about 0 C.) pentane, and a light green solid precipitated. The precipitate was filtered, washed with 420 mL of cold pentane, and dried under vacuum to afford (IMesH2)(C7H10N2)2(Cl)2Ru-CHPh 10 as a light green powder (1.9 gram, 99% yield). [00127] 1H NMR (500 MHz, CD2Cl2): d19.10 (s, 1H, CHPh), 8.18 (d, 2H, pyridine CH, JHH=6.5 Hz), 7.64 (d, 2H, ortho CH, JHH=7.5 Hz), 7.48 (t, 11H, para CH, JHH=7.0 Hz), 7.38 (d, 2H, pyridine CH, JHH=6.5 Hz), 7.08 (t, 2H, meta CH, JHH=7.5 Hz), 7.00 (br. s, 2H, Mes CH), 6.77 (br. s, 2H, Mes CH), 6.49 (d, 2H, pyridine CH, JHH=6.0 Hz), 6.15 (d, 2H, pyridine CH, JHH=7.0 Hz), 4.07 (br. d, 4H, NCH2CH2N), 2.98 (s, 6H, pyridine CH3), 2.88 (s, 6H, pyridine CH3), 2.61-2.21 (multiple peaks, 18H, Mes CH3).

Reference£º
Patent; California Institute of Technology; Cymetech, LLP; US6759537; (2004); B2;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of 246047-72-3

To a suspension of copper(I) chloride (13 mg, 0.12 mmol) and tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride (102 mg; 0.12 mmol) in 2 ml of dichloromethane was added a solution of the appropriate styrene derivative (0.132 mmol) dissolved in 3 ml of dichloromethane. After stirring at 40 C. for 20 min, the reaction solution was concentrated under reduced pressure. The residue was taken up in 20 ml of ethyl acetate and filtered through a Pasteur pipette with silica gel. The filtrate was concentrated again under reduced pressure and the residue was washed with a very small amount of ethyl acetate and cold pentane.

Reference£º
Patent; Kadyrov, Renat; Szadkowska, Anna; Grela, Karol; Barbasiewicz, Michal; US2008/275247; (2008); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Brief introduction of 246047-72-3

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

A suspension of 1.00 g (1.18 mmol) of [RuCl2(PCy3)(ImH2Mes)(phenylmethylene)] (commercially available from Sigma- Aldrich Inc., St. Louis, USA), 0.13 g (1.30 mmol) of copper chloride and 0.36 g (1.30 mmol) of 2-[((?,Z)-2-propenyl)-phenoxy]-l -pyrrolidine- 1-yl- propan-1-one as a 4:1 mixture ofE/Z-isomers in 75 ml of dichloromethane was stirred for 30 min at 400C. The reaction mixture was evaporated to dryness at 400C/ 10 mbar. The residue was stirred in 60 ml of ethyl acetate for 30 min at room temperature. The dark green suspension was filtered and the filtrate was evaporated to dryness at 40C/10 mbar. The crude title product was purified by silica gel chromatography (dichloromethane/methanol 98:2) to yield 0.52 g (62% yield) of the title compound as a green powder.MS: 709.2 (M+). Anal, calcd. for C35H43Cl2N3O2Ru ? 0.85 CH2Cl2: C, 55.04; H, 5.76; N, 5.37, Cl 16.83. Found: C, 54.52; H, 5.74; N, 5.29, Cl 16.82.

246047-72-3, As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/124853; (2009); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of 246047-72-3

To a 40 mL scintillation vial equipped with a magnetic stir bar were added C848 (0.500 g, 0.589 mmol),^-toluenesulfonyl chloride (0.056 g, 0.30 mmol), dimethyl sulfoxide (0.230 g, 2.94 mmol), and dichloromethane (4 mL). The reaction was stirred at ambient temperature for one hour then filtered through a plug of celite and combined with diethyl ether (30 mL). The resulting purple precipitate was isolated by filtration, washed with diethyl ether (2 x 10 mL) then dried in vacuum to afford C647m as a purple crystalline solid (0.269 g, 70.7% yield). The X-ray structure of C647m is shown in Figure 2. MR (400 MHz, CeDe) delta 16.03 (s, 1H), 8.15 (d, J = 25.0 Hz, 2H), 7.21 (t, J = 7.3 Hz, 1H), 7.00 (t, J= 7.8 Hz, 2H), 6.84 (s, 1H), 6.75 (s, 1H), 6.65 (s, 1H), 6.17 (s, 1H), 3.33 – 3.00 (m, 4H), 2.87 (s, 3H), 2.67 (s, 3H), 2.61 (s, 3H), 2.22 (s, 3H), 2.14 (s, 3H), 2.07 (s, 3H), 2.04 (s, 3H), 1.98 (s, 3H).

Reference£º
Patent; MATERIA, INC.; JOHNS, Adam, M.; (112 pag.)WO2018/38928; (2018); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of 246047-72-3

Grubbs second generation catalyst (100 mg, 0.117 mmol), 2-[(2,6-dimethylphenylimino)methyl]phenol (pKa: 8.85+/-0.30) (0.117 mmol), silver (I) carbonate (16.27 mg, 0.058 mmol), and THF (2 ml) were reacted at room temperature during 2 h. The solvent was evaporated and crude reaction product purified on a chromatography column to give an orange-brown complex. Yield 22%.

Reference£º
Patent; Telene S.A.S.; US2011/137043; (2011); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Analyzing the synthesis route of 246047-72-3

Grubbs second generation catalyst (100 mg, 0.117 mmol), 2-[(2,6-dimethylphenylimino)methyl]phenol (pKa: 8.85+/- 0.30) (0.117 mmol), silver (I) carbonate (16.27 mg, 0.058 mmol), and THF (2 ml) were reacted at room temperature during 2 h. The solvent was evaporated and crude reaction product purified on a chromatography column to give an orange-brown complex. Yield 22%.

Reference£º
Patent; Telene SAS; EP2151446; (2010); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI