Category: 2407-11-6

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gallagher, Peter T.; Iddon, Brian; Suschitzky, Hans researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).HPLC of Formula: 2407-11-6.They published the article 《Synthesis and reactions of azidobenzothiazoles and -benzo[b]thiophenes. Novel thiazolo[4,5-g]benzoxazoles and dihydrothieno[3,2-g]benzoxazoles》 about this compound( cas:2407-11-6 ) in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Keywords: azidobenzothiazole thermolysis thiazolobenzoxazole; azidodihydrobenzothiophene dioxide thermolysis dihydromethylthienobenzoxazole; hydromethylthienobenzoxazole dioxide; thienobenzoxazole dioxide dihydro methyl; fluoronitrobenzothiazole; chloronitrobenzothiazole fluoride substitution; nitrobenzothiazole fluoro; benzothiazole nitro fluoro. We’ll tell you more about this compound (cas:2407-11-6).

6-Azidobenzothiazole and its 2-Me and 2-(methylthio) derivatives, prepared from the corresponding amines by diazotization and reaction with NaN3, gave the thiazolo[4,5-g]benzoxazoles I (R = H, Me, SH) (50, 42 and 20%, resp.) on thermolysis (120°, 1.5 h) in a polyphosphoric acid-HOAc mixture Under similar conditions 6-azido-2,3-dihydrobenzo[b]thiophene 1,1-dioxide gave 11% II. 2-Fluoro-6-nitrobenzothiazole was prepared in almost quant. yield by reaction of the chloro analog with F- in MeCN containing 18-crown-6.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])HPLC of Formula: 2407-11-6, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzothiazoles. VIII. Nitration of 2-substituted benzothiazoles》. Authors are Mizuno, Yoshihisa; Adachi, Kikuo; Nakamura, Kaname.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Product Details of 2407-11-6. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

NaOH (1 g.), 1 ml. water, 16 ml. EtOH, and 2 g. 2-methoxybenzothiazole (XI) boiled 15 min. on a steam bath, the solution cooled, poured into 80 ml. water, acidified with 5 ml. concentrated HCl, let stand overnight, and the precipitate filtered gave 1.6 g. (0.3 g. from the mother liquor) unchanged XI, m. 32-3°; (picrate, m. 100-1°); nitration of 2.1 g. of recovered XI gave 1.7 g. mono-NO2 derivative, m. 164-5°; nitration of 10 g. benzothiazole (XII) in 50 ml. H2SO4 with 5 ml. 98% H2SO4 and 4 ml. fuming HNO3 (d. 1.5) at 0°, the solution poured into ice water, filtered and dried, yielded 62% 6-O2N derivative (XIIIA) of XII, m. 170-2° and 9.1% 7-O2N derivative (XIIIB), m. 150-4°; similarly, 2-chlorobenzothiazole (XIV) yielded 42.6% 6-O2N derivative of XIV, m. 191-3° (nitration at 30-5° increased the yield to 75%); 5 g. of the nitrated product, m. 102-15°, of I, 60 ml. concentrated HCl, and 18 g. SnCl2.2H2O heated 1 hr. on a water bath gave the NH2 derivatives which were dissolved in 7 ml. 18% HCl, diazotized with 0.92 g. NaNO2 in 1 ml. water, and the diazo compound converted into the Cl derivative gave 1.5 g. 6-Cl derivative (XVI) of I (picrate, m. 132-4°) (141°, recrystallized from EtOH); nitration of V at 0° and 30-5° yielded 28 and 45%, resp., of 6-O2N derivative (XVII) of V, m. 187°; nitration of XI at 0-2° yielded 72% 6-O2N derivative, m. 165-6°, and 10% 2-hydroxy-6-nitrobenzothiazole (XVIII), m. 226°; no nitration product was obtained from 2-nitrobenzothiazole.

In some applications, this compound(2407-11-6)Product Details of 2407-11-6 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Tacrine-Benzothiazoles: Novel class of potential multitarget anti-Alzheimers drugs dealing with cholinergic, amyloid and mitochondrial systems, the main research direction is design synthesis evaluation tacrine benzothiazole compound; tacrine benzothiazole multitarget anti Alzheimers drug; ABAD; Acetylcholinesterase Inhibitors; Alzheimer’s disease; Amyloid β; Benzothiazole; MTDLs; Tacrine.Electric Literature of C7H3ClN2O2S.

A series of tacrine – benzothiazole hybrids incorporate inhibitors of acetylcholinesterase (AChE), amyloid β (Aβ) aggregation and mitochondrial enzyme ABAD, whose interaction with Aβ leads to mitochondrial dysfunction, into a single mol. In vitro, several of 25 final compounds exerted excellent anti-AChE properties and interesting capabilities to block Aβ aggregation. The best derivative of the series could be considered I that was found to be highly potent and selective towards AChE with the IC50 value in nanomolar range. Moreover, the same drug candidate exerted absolutely the best results of the series against ABAD, decreasing its activity by 23% at 100μM concentration Regarding the cytotoxicity profile of highlighted compound, it roughly matched that of its parent compound 6-chlorotacrine. Finally, I was forwarded for in vivo scopolamine-induced amnesia experiment consisting of Morris Water Maze test, where it demonstrated mild precognitive effect. Taking into account all in vitro and in vivo data, highlighted derivative I could be considered as the lead structure worthy of further investigation.

In some applications, this compound(2407-11-6)Electric Literature of C7H3ClN2O2S is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application of 2407-11-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Acylotropic tautomerism. XXII. Structure of the heterocyclic ring and kinetics of heterylotropic rearrangement in a series of O-derivatives of 3,5,7-trimethyltropolone.

Rate constants and activation parameters were determined for the migration of heteroaromatic fragments (R) between the O atoms in tropolones I. The reactivity decreased in the following order of R: dichloro-s-triazin-2-yl ≫ 3,5-dinitro-2-pyridyl > 5-nitro-2-pyrimidinyl > 3-cyano-5-nitro-2-pyridyl > 5-cyano-4-pyrimidinyl > 6-nitro-2-benzothiazolyl.

In some applications, this compound(2407-11-6)Application of 2407-11-6 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Category: ruthenium-catalysts. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives. Author is Delmas, Florence; Avellaneda, Antonio; Di Giorgio, Carole; Robin, Maxime; De Clercq, Erik; Timon-David, Pierre; Galy, Jean-Pierre.

(1,3-Benzothiazol-2-yl) amino-9-(10H)-acridinones were synthesized via a procedure based on the Ullman reaction and were assessed for their in vitro antileishmanial and anti-HIV activities. Two derivatives, 4-(6-nitro-benzothiazol-2-ylamino)-10H-acridin-9-one (I) and 1-(6-amino-benzothiazol-2-ylamino)-10H-acridin-9-one (II), revealed a selective antileishmanial activity, mainly due to amastigote-specific toxicity. Results suggested that the addition of a benzothiazole group on a parent amino-9-(10H)-acridinone ring could enhance antileishmanial abilities, the presence of a 6-amino-benzothiazole group on position 2 amino chain or a 6-nitro-benzothiazole group on position 4 amino chain was essential for specific anti-amastigote properties.

In some applications, this compound(2407-11-6)Category: ruthenium-catalysts is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Activity of benzothiazoles and chemical derivatives on Plasmodium falciparum, published in 2004-11-30, which mentions a compound: 2407-11-6, mainly applied to benzothiazole plasmodium falciparum QSAR antimalarial, Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole.

Malaria is a major health concern particularly in Africa which has about 90% of the worldwide annual clin. cases. The increasing number of drug-resistant Plasmodium falciparum justifies the search for new drugs in this field. Antimalarial activity of 2-substituted 6-nitro- and 6-amino-benzothiazoles and their anthranilic acids has been tested. An in vitro study has been performed on W2 and 3D7 strains of P. falciparum and on clin. isolates from malaria-infected patients. Toxicity has been assessed on THP1 human monocytic cells. For the most active drug candidates, the in vitro study was followed by in vivo assays on P. berghei-infected mice and by in vitro assays in order to determine the stage-dependency and the mechanism of action. Of 39 derivatives tested in vitro, 2 had specific antimalarial properties. Each compound was active on all stages of the parasite, but one was markedly active on mature schizonts, while the other was more active on young schizont forms. Both drugs were also active on mitochondrial membrane potential. In vivo data confirmed efficiency with a sustained decrease of parasitemia. Products A12 and C7 may be considered as potential antimalarial worthy of further chem. and biol. research.

In some applications, this compound(2407-11-6)Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Developing Visible Fluorogenic ‘Click-On’ Dyes for Cellular Imaging, published in 2011-09-21, which mentions a compound: 2407-11-6, mainly applied to visible fluorogenic click on dye cellular imaging, Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole.

New fluorogenic dyes were designed and synthesized based on Cu(I)-catalyzed click reaction. Conjugating weakly fluorescent benzothiazole derivatives with an electron-deficient alkyne group at the 2-position with azide-containing mols. in aqueous solution form click-on fluorescent adducts. Model reactions and cell culture experiment indicated that the developed click-on’ dye could be applied to labeling various biomols., such as nucleic acids, proteins, and other mols., in cells.

When you point to this article, it is believed that you are also very interested in this compound(2407-11-6)Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole and due to space limitations, I can only present the most important information.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Nucleophilic reactivity of 2-chlorobenzothiazole》. Authors are Todesco, Paolo Edgardo; Vivarelli, Piero.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Safety of 2-Chloro-6-nitrobenzo[d]thiazole. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

The reaction of MeONa with 5- or 6-substituted derivatives of 2-chlorobenzothiazole has been studied. 2-Chlorobenzothiazole (I), b21 133-4°, was prepared according to Moon (CA 43, 6670c). The 6-nitro derivative (II) of I, pale yellow needles, m. 191-2°, was prepared by nitrating I with KNO3 and H2SO4 (U.S. 2,659,730, CA 49, 2519a; Katz, CA 46, 3044b). The 5-nitro derivative (III) of I, m. 112°, was prepared by adding an excess of SO2Cl2, in the cold, to 0.003 mole of 2-mercapto-5-nitrobenzothiazole, crude m. 223-5°, prepared in turn in 60% yield, by adding a KSH solution (0.01 mole KOH in little water and 30 ml. alc., saturated with H2S) to a boiling alc. solution of 2-bromo-5-nitroaniline, cooling, adding 0.3 ml. CS2, stirring 4 hrs. at 80°, steam distilling, cooling, making ammoniacal, filtering off S, and precipitating the product by making acid with HCl. The 4-nitro derivative (IV) of I, yellow needles, m. 169-70°, was prepared by diazotizing 2-amino-4-nitrobenzothiazole (Erlenmeyer and Ueberwasser, CA 34, 28446), m. 254°, and decomposing the diazonium salt with cold Cu2Cl2-HCl. The 6-methyl derivative (V) of I, m. 49-50°, resulted from 2-amino-6-methylbenzothiazole, m. 135-6°, according to Metzger and Plank (CA 50, 15512a). The 5-methyl derivative (VI) of I, m. 41-2° (cold pentane) was made by treating 2-mercapto-4-methylbenzothiazole with SO2Cl2, the intermediate being prepd, according to Teppema and Sebrell (CA 21, 2688). The 6-chloro derivative (VII) of I, m. 98-9°, was prepared by diazotizing 2-amino-6-chlorobenzothiazole, m. 200°, in a mixture of HCO2H, AcOH, and HCl, and decomposing the diazo salt with Cu2Cl2-HCl (Stuckwisch, CA 44, 2514a). The intermediate was obtained according to Kaufmann and Kuchler (CA 28, 50666). The 5-chloro derivative (VIII) of I, m. 70-1°, was prepared by treating 2-mercapto-5-chlorobenzothiazole, m. 196-7°, with SO2Cl2. The 6-methoxy derivative (IX) of I, m. 53-4°, was prepared according to Stuckwisch (loc. cit.). For the reaction with Me-ONa, MeOH solutions of the reagents, previously brought to reaction temperature, were mixed and kept at const, temperature, taking samples at intervals and pouring them into an excess of aqueous HNO3, followed by AgNO3, and determining Cl- by the Volhard method. The resulting data were plotted and used to calculate the rate constant and energy of activation of the reactions. The second-order rate const, k (103 sec.-1 mole-1) for 0°, 13°, 25°, 35°, and 45°, followed by the activation energy E (kcal. mole-1) for the various derivatives of I: I, -, -, 0.55, 1.43, 3.39, 16.9; IV, -, 42.8, 132.0, 335.0, -, 16.3; III, 8.09, -, 87.8, 205.0, -, 15.4; VIII,-, 2.53, 6.37, 15.20, -, 15.8; VI, -, 0.116, 0.374, 1.05, -, 17.8; II, -, 97.0, 280.0, 647.0, -, 14.2; VII, -, 1.01, 3.25, 7.79, -, 16.0; V, -, 0.057, 0.197, 0.578, -, 18.3; and IX, -, 0.0244, 0.0893, 0.255, -, 18.7. Electron-attracting substituents (Cl, NO2) speed up the reaction, while electron-donor substituents (Me, MeO) slow it down. The log k of the reaction gave a straight line function of Hammett’s σ (of. Jaffe, Chem. Rev. 53, 191(1953)), except in the case of II.

When you point to this article, it is believed that you are also very interested in this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole and due to space limitations, I can only present the most important information.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Watson, Brett T. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).COA of Formula: C7H3ClN2O2S.They published the article 《Potassium hexamethyldisilazide》 about this compound( cas:2407-11-6 ) in e-EROS Encyclopedia of Reagents for Organic Synthesis. Keywords: review potassium hexamethyldisilazide diastereoselective regioselective Horner Wadsworth Emmons olefination; lactonization Peterson alkenation Cope rearrangement cyclization review Julia olefination. We’ll tell you more about this compound (cas:2407-11-6).

A review. Properties, handling and reactivity of potassium hexamethyldisilazide in diastereoselective Horner-Wadsworth-Emmons olefination, intramol. lactonization, Peterson-type alkenation, Cope rearrangement, cyclization, condensation, epoxidation and Julia olefination were briefly reviewed.

Here is just a brief introduction to this compound(2407-11-6)COA of Formula: C7H3ClN2O2S, more information about the compound(2-Chloro-6-nitrobenzo[d]thiazole) is in the article, you can click the link below.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Research on benzothiazole. VII. Effect of halogen on the nucleophilic reactivity of 2-halobenzothiazoles》. Authors are Ricci, Alfredo; Todesco, Paolo Edgardo; Vivarelli, Piero.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Formula: C7H3ClN2O2S. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

cf. CA 61, 8291e. The reactions of a series of 2-halobenzothiazoles and the corresponding 6-nitro derivatives with MeO- and PhS- were studied in MeOH at 25°. 2-Fluorobenzothiazole reacts with MeO- about 20 times faster than with PhS-. With the other 2-halo derivatives, the reactivity with MeO- and PhS- is comparable. Only in the 6-nitro derivatives was the normal Ph- >>MeO- reactivity found. In both series with MeO- the order of reactivity was F>>Cl>Br>I and this was correlated with the 6 para values for the halogens. A linear relationship was found between the polarizability of the leaving group (as measured by the log of the C-halogen bond refractivity constant) and the log of kPhS-/ k MeO-.

Here is just a brief introduction to this compound(2407-11-6)Formula: C7H3ClN2O2S, more information about the compound(2-Chloro-6-nitrobenzo[d]thiazole) is in the article, you can click the link below.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI