Category: 2407-11-6

Reference of 2-Chloro-6-nitrobenzo[d]thiazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about A DBU-diheteroaryl halide adduct as the fastest current N-diheteroarylating agent. Author is Verma, Sanjeev K.; Acharya, B. N.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik, M. P..

An unexpected diazabicyclo[5.4.0]undec-7-ene (DBU) catalyzed rate enhancement of N-arylation of amines with diheteroaryl halides was reported. DBU was found to activate the Ar-Cl bond of a diheteroaryl halide, forming a green colored adduct under neat conditions. The activated green colored adduct was used for the arylation of amines under neat conditions and was found to be the fastest diheteroarylating agent reported to date.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Lu, Linhua; Yan, Hong; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng published an article about the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-] ).Computed Properties of C7H3ClN2O2S. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2407-11-6) through the article.

Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Computed Properties of C7H3ClN2O2S, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Antituberculous compounds. II. 2-(Benzylidenehydrazino)benzothiazoles》. Authors are Katz, Leon.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

cf. C.A. 46, 933g. 2-Chlorobenzothiazole (I) (170 g.) added during 1 hr. to 300 g. gently refluxing 85% N2H4.H2O (5.1 moles), and the slurry refluxed 15 min., cooled, and filtered yielded 150.6 g. 2-hydrazinobenzothiazole (II), m. 197-9° (all m.ps. uncorrected). p-H2NC6H4CHO (0.075 mole) and 30 g. AcOH heated to 100°, 45 g. succinic anhydride added, the mixture held 3.5 hrs. at 95-100°, diluted with 150 cc. AcOH, let cool overnight, filtered, the dried, powd. cake in 300 cc. water containing 50 cc. concentrated NH4OH stirred 1 hr., 20 g. Supercel added, the mixture filtered, the filtrate acidified with 6 N HCl, and the precipitate filtered off and washed with 500 cc. water yielded 12.5 g. p-(succinylamino)benzaldehyde, HO2CCH2CH2CONHC6H4CHO (III), pale yellow cubes from HCONH2, m. 231-2.5°. p-AcNHC6H4CHO (13.5 g.) added to 150 cc. boiling AcOH and 16.9 g. II, and the slurry stirred 10 min., cooled, filtered, and washed with 300 cc. MeOH yielded 19.5 g. white solid (3.4 g. more from the filtrate), m. 291-3° (from AcOH) (also given as 294-6° from HCONH2, compound 4 below). The preceding method was used for compounds 1-7 below. I (101 g.) added dropwise during 30 min. to 800 g. concentrated H2SO4 at 10-17°, 66 g. powd. KNO3 added portionwise during 1 hr. to the solution cooled to 12° (temperature not to exceed 18°), the solution stirred 15 min., warmed to 25° 30 min., and, after the temperature had risen to 40°, poured into 4 l. ice and water, 6 l. water added, and the solid filtered off yielded 122 g. 2-chloro-6-nitrobenzothiazole (IV), m. 190-1° (from EtOH). N2H4.H2O (300 g.), preheated to 80°, added to 2 l. refluxing EtOH containing 57.0 g. IV, and the mixture stirred 15 min., filtered hot, and washed with 500 cc. EtOH yielded 48.2 g. 6-nitro-2-hydrazinobenzothiazole (V), m. 264-6° (decomposition) (from HCONMe2). Compounds 8-14 below were prepared by the following method: p-HOC6H4CHO (15.0 g.) added to 21.0 g. V and 150 cc. dioxane in 500 cc. boiling AcOH, and the solution held 15 min. at 105-7°, cooled to room temperature overnight, filtered, and washed with 250 cc. MeOH yielded 18.1 g. compound 8; the filtrate, diluted to 1.33 l. with water, yielded 4.9 g. more. III (8.8 g.) in 50 cc. boiling water containing 3 cc. concentrated NH4OH added to 350 cc. boiling AcOH containing 11.0 g. V and 10 cc. HCONH2, and the mixture cooled to room temperature, diluted with 300 cc. MeOH, and filtered yielded 14.1 g. compound 13, m. 319-21°. IV (21.0 g.) added portionwise during 1 hr. to 150 cc. EtOH, 10 g. AcOH, 250 cc. water, and 50 g. 100-mesh Fe which had been heated to 80-5° 30 min., the mixture held at 80° 1 hr., 200 cc. EtOH and 10 g. Darco G-60 added, the mixture refluxed 15 min., filtered hot into 250 cc. water, and the filtrate chilled yielded 13.8 g. 6-amino-2-chlorobenzothiazole (VI), m. 155-7°. AcCl (10.8 g.) added dropwise during 20 min. to 18.4 g. VI and 70 cc. pyridine at 10°, and the mixture stirred 30 min. at 0-10°, poured into 800 cc. water, and filtered yielded 21.6 g. 6-Ac derivative (VII), fine white needles from the min. amount of EtOH added to 40 volumes hot water, m. 131-2°. VII (42.5 g.) added quickly to 150 g. boiling N2H4.H2O, the slurry diluted with 125 cc. hot water, boiled 5 min., 150 g. ice added, and the mixture filtered yielded 38.3 g. 6-acetamido-2-hydrazinobenzothiazole (VIII), m. 233-5° (from aqueous MeOH). Compounds 15-20 were prepared by the following method: VIII (3.0 g.) in 100 cc. boiling 25% AcOH treated with 3.0 g. p-HOC6H4CHO, and the mixture stirred 10 min., cooled, and filtered yielded 3.4 g. compound 15, m. 274-7°. VI (10 g.) and 50 g. N2H4.H2O boiled 5 min., cooled to 20°, and filtered yielded 8.6 g. 6-amino-2-hydrazinobenzothiazole, m. 209.5-11° (from iso-PrOH). Pyridine (20 cc.), 1.3 g. VI, and 2.0 g. PhSO2Cl heated to boiling, and the solution cooled and poured into 150 cc. water yielded 2.1 g. 2-chloro-6-(phenylsulfonamido)benzothiazole (IX), m. 176-7.5° (from aqueous EtOH). IX (2.1 g.) and 20 g. N2H4.H2O boiled 5 min., cooled, and neutralized with 6 N H2SO4 yielded 1.7 g. 2-hydrazino-6-(phenylsulfonamido)benzothiazole, pale yellow crystals from PhMe-EtOH, m. 214-16°. For the 2-(benzylidinehydrazino)benzothiazoles (X), the compound number, R, R1, yield (%), m.p. (uncorrected), and recrystallization solvent are: 1, H, OH, 80,253-4.5°, AcOH; 2, H, Ac, 70, 194-5°, iso-PrOH; 3, H, OCH2CO2H, 81, 254-7° dioxane; 4, H, NHAc, 89, 294-6°, HCONH2; 5, H, NMe2, 77, 243-4.5° iso-PrOH; 6, H, NHCOCH2CH2CO2H, 91, 255-7°, AcOH; 7, H, CO2H, 86, 319-20°, HCONH2; 8, NO2, OH, 73, 318-19°, HCONH2; 9, NO2, OMe, 72, 299-300° AcOH; 10, NO2, OCH2CO2H, 68, 280-1.5° HCONH2; 11, NO2, NHAc, 70, 312-13° HCONMe2; 12, NO2, NMe2, 77, 263-5° AcOH; 13, NO2, NHCOCH2CH2CO2H, 81, 326-8°, HCONH2; 14, NO2, CO2H, 69, 331-2° AcOHHCONH2 (3:2); 15, NHAc, OH, 77, 279-81°, 50% aqueous HCONH2; 16, NHAc, OMe, 93, 262-3° HCONH2; 17, NHAc, OCH2CO2H, 84, 296-7° HCONH2; 18, NHAc, NHAc, 89, 292-3°, HCONH2; 19, NHAc, NMe2, 91, 286-7° HCONH2; 20, NHAc, CO2H, 86, 326-7°, AcOH. Compounds 3 and 5 were the most active.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors, published in 2016-08-25, which mentions a compound: 2407-11-6, mainly applied to imidazoquinoline derivative preparation cancer osaka thyroid kinase inhibitor antiinflammatory, Recommanded Product: 2407-11-6.

Cancer Osaka thyroid (COT) kinase is an important regulator of pro-inflammatory cytokines in macrophages. Thus, pharmacol. inhibition of COT should be a valid approach to therapeutically intervene in the pathogenesis of macrophage-driven inflammatory diseases such as rheumatoid arthritis. We report the discovery and chem. optimization of a novel series of COT kinase inhibitors, with unprecedented nanomolar potency for the inhibition of TNFα. Pharmacol. profiling in vivo revealed a high metabolism of these compounds in rats which was demonstrated to be predominantly attributed to aldehyde oxidase. Due to the very low activity of hepatic AO in the dog, the selected candidate 32 displayed significant blood exposure in dogs which resulted in a clear prevention of inflammation-driven lameness. Taken together, the described compounds both potently and selectively inhibit COT kinase in primary human cells and ameliorate inflammatory pathologies in vivo, supporting the notion that COT is an appropriate therapeutic target for inflammatory diseases.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

SDS of cas: 2407-11-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about HFIP promoted thio(hetero)arylation of imidazoheterocycles under metal- and base-free conditions. Author is Chaubey, Narendra R.; Kapdi, Anant R..

A new reaction methodol. has been developed for HFIP promoted Thio(hetero)arylation of imidazoheterocycles I (R = H, 4-Me, 4-CN, 3-Br, etc.) under metal and base-free conditions. This is the first report that describes linking of imidazopyridines I with electron deficient heteroarenes R1Cl (R1 = 2-benzothiazolyl, 2-pyrazinyl, 2-quinoxalinyl, 3-fluoro-2-pyridinyl, etc.) through a sulfur atom and also for the synthesis of most of these compds II. The reaction conditions are well tolerated by almost all kinds of 2-chloroheteroarenes and a wide range of imidazoheterocycles I. The synthesized compounds II can show significant biol. properties.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])SDS of cas: 2407-11-6, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.HPLC of Formula: 148-51-6. The article 《Bioorthogonal Catalysis: A General Method To Evaluate Metal-Catalyzed Reactions in Real Time in Living Systems Using a Cellular Luciferase Reporter System》 in relation to this compound, is published in Bioconjugate Chemistry. Let’s take a look at the latest research on this compound (cas:2407-11-6).

The development of abiol. catalysts that can function in biol. systems is an emerging subject of importance with significant ramifications in synthetic chem. and the life sciences. Herein we report a biocompatible ruthenium complex [Cp(MQA)Ru(C3H5)]+PF6-2 (Cp = cyclopentadienyl, MQA = 4-methoxyquinoline-2-carboxylate) and a general anal. method for evaluating its performance in real time based on a luciferase reporter system amenable to high throughput screening in cells and by extension to evaluation in luciferase transgenic animals. Precatalyst 2 activates alloc-protected aminoluciferin 4b, a bioluminescence pro-probe, and releases the active luminophore, aminoluciferin (4a), in the presence of luciferase-transfected cells. The formation and enzymic turnover of 4a, an overall process selected because it emulates pro-drug activation and drug turnover by an intracellular target, is evaluated in real time by photon counting as 4a is converted by intracellular luciferase to oxyaminoluciferin and light. Interestingly, while the catalytic conversion (activation) of 4b to 4a in water produces multiple products, the presence of biol. nucleophiles such as thiols prevents byproduct formation and provides almost exclusively luminophore 4a. Our studies show that precatalyst 2 activates 4b extracellularly, exhibits low toxicity at concentrations relevant to catalysis, and is comparably effective in two different cell lines. This proof of concept study shows that precatalyst 2 is a promising lead for bioorthogonal catalytic activation of pro-probes and, by analogy, similarly activatable pro-drugs. More generally, this study provides an anal. method to measure abiol. catalytic activation of pro-probes and, by analogy with our earlier studies on pro-Taxol, similarly activatable pro-drugs in real time using a coupled biol. catalyst that mediates a bioluminescent readout, providing tools for the study of imaging signal amplification and of targeted therapy.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2407-11-6, is researched, Molecular C7H3ClN2O2S, about Benzothiazole derivatives. VII. Synthesis of some N-(2-benzothiazolyl)anthranilic acids as potential antiinflammatory agents, the main research direction is anthranilate benzothiazolyl antiinflammatory; benzothiazolylanthranilate antiinflammatory; benzothiazoloquinolinone cleavage.Name: 2-Chloro-6-nitrobenzo[d]thiazole.

The benzothiazoles I (R = H, Cl, NO2) were cyclized with 2,4,5-H2NR1R2C6H2CO2H (R1 = H, Cl, Br; R2 = H, Br) to give the benzothiazoloquinazolinones II, which were cleaved with KOH to give the title compounds III. At 60 mg/kg III (R = R2 = H, R1 = Br) inhibited carrageenin induced rat paw edema by 68%.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Name: 2-Chloro-6-nitrobenzo[d]thiazole, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

SDS of cas: 2407-11-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Structure-activity relationships of benzothiazole GPR35 antagonists. Author is Abdalhameed, Manahil M.; Zhao, Pingwei; Hurst, Dow P.; Reggio, Patricia H.; Abood, Mary E.; Croatt, Mitchell P..

The first structure-activity relationships for a benzothiazole scaffold acting as an antagonist at GPR35 is presented. Analogs were designed based on a lead compound that was previously determined to have selective activity as a GPR35 antagonist. The synthetic route was modular in nature to independently explore the role of the middle and both ends of the scaffold. The activities of the analogs illustrate the importance of all three segments of the compound

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])SDS of cas: 2407-11-6, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents, the main research direction is triazolbenzothiazole derivative preparation click chem neuroprotective agent.Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole.

A series of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole and 2-azidobenzo[d]thiazole starting materials. Moreover, compound I, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C7H3ClN2O2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Luciferin Derivatives for Enhanced in Vitro and in Vivo Bioluminescence Assays. Author is Shinde, Rajesh; Perkins, Julie; Contag, Christopher H..

In vivo bioluminescence imaging has become a cornerstone technol. for preclin. mol. imaging. This imaging method is based on light-emitting enzymes, luciferases, which require specific substrates for light production When linked to a specific biol. process in an animal model of human biol. or disease, the enzyme-substrate interactions become biol. indicators that can be studied noninvasively in living animals. Signal intensity in these animal models depends on the availability of the substrate for the reaction within living cells in intact organs. The biodistribution and clearance rates of the substrates are therefore directly related to optimal imaging times and signal intensities and ultimately determine the sensitivity of detection and predictability of the model. Modifications of D-luciferin, the substrate for the luciferases obtained from beetle, including fireflies, result in novel properties and offer opportunities for improved bioassays. For this purpose, the authors have synthesized a conjugate, glycine-D-aminoluciferin, and investigated its properties relative to those of D-aminoluciferin and D-luciferin. The three substrates exhibited different kinetic properties and different intracellular accumulation profiles due to differences in their mol. structure, which in turn influenced their biodistribution in animals. Glycine-D-aminoluciferin had a longer in vivo circulation time than the other two substrates. The ability to assay luciferase in vitro and in vivo using these substrates, which exhibit different pharmacokinetic and pharmacodynamic properties, will provide flexibility and improve current imaging capabilities.

There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Formula: C7H3ClN2O2S, and with the development of science, more effects of this compound(2407-11-6) can be discovered.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI