Category: 2407-11-6

Name: 2-Chloro-6-nitrobenzo[d]thiazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry. Author is Anderson, Zoe J.; Hobson, Christian; Needley, Rebecca; Song, Lijiang; Perryman, Michael S.; Kerby, Paul; Fox, David J..

A simple 1H and 13C NMR spectrometric anal. is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chem. shift and coupling constants of the signals associated with the proton and carbon at the α-stereocenter. This is applied to the estimation of epimerization during metal-free N-arylation and peptide coupling reactions.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bartoli, Giuseppe; Latrofa, Andrea; Todesco, Paolo E. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Category: ruthenium-catalysts.They published the article 《Experimental basis for a broadened Yukawa-Tsuno equation》 about this compound( cas:2407-11-6 ) in Gazzetta Chimica Italiana. Keywords: substituents Yukana Tsuno; Ingold Yukana Tsuno; free energy substituents. We’ll tell you more about this compound (cas:2407-11-6).

In systems having a series of electron-attracting or electron-donating substituents, the Ingold-Yukawa-Tsuno equation was applicable to the correlations of free energy with the substituent effect. The reactions between 4-ClC6H4NO2 and 2-chloro-6-nitrobenzothiazole and thiophene oxides substituted with some common meta and para substituents were examined

Compound(2407-11-6)Category: ruthenium-catalysts received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Chloro-6-nitrobenzo[d]thiazole), if you are interested, you can check out my other related articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Aminoluciferins as Functional Bioluminogenic Substrates of Firefly Luciferase, the main research direction is aminoluciferin bioluminogenic firefly luciferase.Related Products of 2407-11-6.

Firefly luciferase is widely used as a reporter gene in assays to study gene expression, gene delivery, and so on because of its extremely high signal-to-noise ratio. The availability of a range of bioluminogenic substrates would greatly extend the applicability of the luciferin-luciferase system. Herein, we describe a design concept for functional bioluminogenic substrates based on the aminoluciferin (AL) scaffold, together with a convenient, high-yield method for synthesizing N-alkylated ALs. We confirmed the usefulness of ALs as bioluminogenic substrates by synthesizing three probes. The first was a conjugate of AL with glutamate, Glu-AL. When Glu-AL, the first membrane-impermeable bioluminogenic substrate of luciferases, was applied to cells transfected with luciferase, luminescence was not observed; i.e., by using Glu-AL, we can distinguish between intracellular and extracellular events. The second was Cy5-AL, which consisted of Cy5, a near-IR (NIR) cyanine fluorescent dye, and AL, and emitted NIR light. When Cy5-AL reacted with luciferase, luminescence derived from Cy5 was observed as a result of bioluminescence resonance energy transfer (BRET) from AL to Cy5. The NIR emission wavelength would allow a signal to be observed from deeper tissues in bioluminescence in vivo imaging. The third was biotin-DEVD-AL (DEVD=the amino acid sequence Asp-Glu-Val-Asp), which employed a caspase-3 substrate peptide as a switch to control the accessibility of the substrate to luciferase, and could detect the activity of caspase-3 in a time-dependent manner. This generalized design strategy should be applicable to other proteases. Our results indicate that the AL scaffold is appropriate for a range of functional luminophores and represents a useful alternative substrate to luciferin.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Thierry, Thibault; Pfund, Emmanuel; Lequeux, Thierry published the article 《Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y》. Keywords: alpha aminoheteroaryl preparation green light irradiation eosin Y catalyst; amines; heterocycles; photocatalysis; photooxidation; redox chemistry; synthetic methods.They researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Recommanded Product: 2407-11-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2407-11-6) here.

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Robust Light Emission from Cyclic Alkylaminoluciferin Substrates for Firefly Luciferase, published in 2010-10-06, which mentions a compound: 2407-11-6, mainly applied to emission cyclic alkylaminoluciferin substrate firefly luciferase, COA of Formula: C7H3ClN2O2S.

Firefly luciferase utilizes the chem. energy of ATP and oxygen to convert its substrate, D-luciferin, into an excited-state oxyluciferin mol. Relaxation of this mol. to the ground state is responsible for the yellow-green light emission. Synthetic cyclic alkylaminoluciferins that allow robust red-shifted light emission with the modified luciferase Ultra-Glo are described. Overall light emission is higher than that of acyclic alkylaminoluciferins, aminoluciferin, and the native substrate D-luciferin.

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)COA of Formula: C7H3ClN2O2S. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application of 2407-11-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Characterization of the reactivity of luciferin boronate – A probe for inflammatory oxidants with improved stability.

Boronate derivatives of luciferin, containing oxidant-activated self-immolative moieties, recently have been developed for bioluminescent detection of hydrogen peroxide in animal models. Here, the authors report the synthesis and characterization of luciferin boronic acid pinacol ester (LBE) as a probe for detection of hydrogen peroxide, hypochlorous acid, and peroxynitrite, with improved stability and response time. HPLC analyses showed that LBE quickly hydrolyzes in phosphate buffer to luciferin boronic acid (LBA). Hydrogen peroxide oxidizes LBA slowly, with the formation of luciferase substrate, luciferin (Luc-OH), as the only product. Hypochlorite also oxidizes LBA to luciferin, but the subsequent reaction of Luc-OH with hypochlorite gives a chlorinated luciferin Luc-OH-Cl, which has a higher fluorescence quantum yield than luciferin at pH 7.4 and is also a substrate for luciferase (Takakura H, et. all. ChemBioChem 2012; 13:1424). Similar to other boronate probes, LBA is oxidized by peroxynitrite in two pathways. Luc-OH is the product of the major pathway, common for all the oxidants tested, whereas the non-fluorescent nitrated derivative, Luc-NO2, is formed in the minor pathway, specific for peroxynitrite. Formation of luciferin radical intermediate in the minor pathway has been confirmed by EPR spin trapping and mass spectrometric analyses of the spin adducts. LBE shows potential as an improved probe for the detection of inflammatory oxidants in biol. settings. Complementation of the bioluminescence measurements by HPLC or LC-MS-based identification of chlorinated and nitrated luciferin(s) will help identify the oxidants detected.

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)Application of 2407-11-6. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzothiazole. I. Nitration and bromination of 2-chlorobenzothiazole》. Authors are Colonna, Martino.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).SDS of cas: 2407-11-6. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

According to the hypothesis of Bonino (C.A. 34, 323.6) direct “”cationoid”” substitution (halogenation, nitration, etc.) of benzothiazole (I) should be directed toward the positions of the H atoms statistically pos., i. e., 4 or 6, while “”anionoid”” substitution (e. g., with NaNH2, NH2OH, etc.) should be directed toward the positions of the H atom statistically neg., i. e., 2. In order to test these predictions, 2-chlorobenzothiazole (II) was prepared (cf. Ger. pat. 516,996 (C.A. 25, 3015)) by the action of PCl5 and POCl3 on 2-mercaptobenzothiazole (III). II dissolved in concentrated H2SO4, treated with EtNO3 at 0°, gives a crystalline precipitate of 2-chloro-6-nitrobenzothiazole (IV), m. 192°, which at 140° (under pressure) with alc. NH3 gives 2-amino-6-nitrobenzothiazole (V), yellow, m. 245° (alc.), identical with the compound obtained by treating p-nitro-aniline with NH4CNS (cf. Kauffmann, C.A. 29, 2660.1). IV with Br in CHCl3 gives 2-chloro-6-bromobenzothiazole, white, m. 100-1°, and the same compound is obtained by treating the diazo derivative of IV with Cu2Br2. The structure of I according to Bonino shows the pyridine-like character of the N atom, and the strictly aromatic character of the benzene nucleus; however, in this nucleus the tricentered bond is fixed, while in other nuclei it is of an oscillating type, as in the equilibrium of quinoline: (VI)⇌ (VII).

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)SDS of cas: 2407-11-6. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Benzothiazole. I. Nitration and bromination of 2-chlorobenzothiazole》. Authors are Colonna, Martino.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).SDS of cas: 2407-11-6. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

According to the hypothesis of Bonino (C.A. 34, 323.6) direct “”cationoid”” substitution (halogenation, nitration, etc.) of benzothiazole (I) should be directed toward the positions of the H atoms statistically pos., i. e., 4 or 6, while “”anionoid”” substitution (e. g., with NaNH2, NH2OH, etc.) should be directed toward the positions of the H atom statistically neg., i. e., 2. In order to test these predictions, 2-chlorobenzothiazole (II) was prepared (cf. Ger. pat. 516,996 (C.A. 25, 3015)) by the action of PCl5 and POCl3 on 2-mercaptobenzothiazole (III). II dissolved in concentrated H2SO4, treated with EtNO3 at 0°, gives a crystalline precipitate of 2-chloro-6-nitrobenzothiazole (IV), m. 192°, which at 140° (under pressure) with alc. NH3 gives 2-amino-6-nitrobenzothiazole (V), yellow, m. 245° (alc.), identical with the compound obtained by treating p-nitro-aniline with NH4CNS (cf. Kauffmann, C.A. 29, 2660.1). IV with Br in CHCl3 gives 2-chloro-6-bromobenzothiazole, white, m. 100-1°, and the same compound is obtained by treating the diazo derivative of IV with Cu2Br2. The structure of I according to Bonino shows the pyridine-like character of the N atom, and the strictly aromatic character of the benzene nucleus; however, in this nucleus the tricentered bond is fixed, while in other nuclei it is of an oscillating type, as in the equilibrium of quinoline: (VI)⇌ (VII).

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)SDS of cas: 2407-11-6. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application of 2407-11-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Characterization of the reactivity of luciferin boronate – A probe for inflammatory oxidants with improved stability.

Boronate derivatives of luciferin, containing oxidant-activated self-immolative moieties, recently have been developed for bioluminescent detection of hydrogen peroxide in animal models. Here, the authors report the synthesis and characterization of luciferin boronic acid pinacol ester (LBE) as a probe for detection of hydrogen peroxide, hypochlorous acid, and peroxynitrite, with improved stability and response time. HPLC analyses showed that LBE quickly hydrolyzes in phosphate buffer to luciferin boronic acid (LBA). Hydrogen peroxide oxidizes LBA slowly, with the formation of luciferase substrate, luciferin (Luc-OH), as the only product. Hypochlorite also oxidizes LBA to luciferin, but the subsequent reaction of Luc-OH with hypochlorite gives a chlorinated luciferin Luc-OH-Cl, which has a higher fluorescence quantum yield than luciferin at pH 7.4 and is also a substrate for luciferase (Takakura H, et. all. ChemBioChem 2012; 13:1424). Similar to other boronate probes, LBA is oxidized by peroxynitrite in two pathways. Luc-OH is the product of the major pathway, common for all the oxidants tested, whereas the non-fluorescent nitrated derivative, Luc-NO2, is formed in the minor pathway, specific for peroxynitrite. Formation of luciferin radical intermediate in the minor pathway has been confirmed by EPR spin trapping and mass spectrometric analyses of the spin adducts. LBE shows potential as an improved probe for the detection of inflammatory oxidants in biol. settings. Complementation of the bioluminescence measurements by HPLC or LC-MS-based identification of chlorinated and nitrated luciferin(s) will help identify the oxidants detected.

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)Application of 2407-11-6. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Robust Light Emission from Cyclic Alkylaminoluciferin Substrates for Firefly Luciferase, published in 2010-10-06, which mentions a compound: 2407-11-6, mainly applied to emission cyclic alkylaminoluciferin substrate firefly luciferase, COA of Formula: C7H3ClN2O2S.

Firefly luciferase utilizes the chem. energy of ATP and oxygen to convert its substrate, D-luciferin, into an excited-state oxyluciferin mol. Relaxation of this mol. to the ground state is responsible for the yellow-green light emission. Synthetic cyclic alkylaminoluciferins that allow robust red-shifted light emission with the modified luciferase Ultra-Glo are described. Overall light emission is higher than that of acyclic alkylaminoluciferins, aminoluciferin, and the native substrate D-luciferin.

I hope my short article helps more people learn about this compound(2-Chloro-6-nitrobenzo[d]thiazole)COA of Formula: C7H3ClN2O2S. Apart from the compound(2407-11-6), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI