Category: 2407-11-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Application In Synthesis of 1,2-Benzisoxazole. The article 《Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:2407-11-6).

We report herein a new site-specific microarray immobilization method based on a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole (CBT). This immobilization strategy has been successfully applied to anchor small mols., peptides and proteins onto microarrays.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.Computed Properties of C7H3ClN2O2S.

A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (I), was developed for Cu sensing in biol. system. I offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biol. system was demonstrated in cell culture.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Derivatives of benzothiazole. II. Obtaining 2-chlorobenzothiazole and some of its derivatives, published in 1937, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Recommanded Product: 2-Chloro-6-nitrobenzo[d]thiazole.

cf. C. A. 32, 160.5. Nitration of 2-mercaptobenzothiazole (I) gives 70% of 6-nitro-2-mercaptobenzothiazole, m. 226°. Reduction of this with H2S gives 75% of the corresponding amine, m. 260-1° and this, by diazotization and treatment with Cu2Cl2 and HCl gives 6-chloro-2-mercaptobenzothiazole (II), m. 244-5°. In an analogous way the 6-I derivative, m. 233-4°, is obtained. By diazotization of 2-aminobenzothiazole, 25% of 2-chlorobenzothiazole (III) is obtained, but if I is heated with PCl5 in POCl3 or PSCl3 at 100° until no more HCl is evolved, 55% of III, b. 248°, is obtained. At the same time a small amount of dibenzothiazolyl 2,2′-monosulfide (IV), m. 106°, is obtained. If the reaction temperature is raised, more IV and less III are formed. Nitration of IV gives a mixture of 6-nitro- and 6,6′-dinitrodibenzothiazolyl 2,2′-monosulfides, m. 142° and 281-2°, resp. Higher nitration temperature favors formation of the dinitro compound Nitration of III gives 83% of 6-nitro-2-chlorobenzothiazole, m. 192°. The same compound is obtained from 6-nitrobenzothiazolyl 2,2′-monosulfide and PCl5, but only in 5% yield. A poor yield of product is also obtained when II is treated with PCl5. Thus, side reactions occur to a very great extent when PCl5 reacts with derivatives of 2-mercaptobenzothiazole.

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Safety of 2-Chloro-6-nitrobenzo[d]thiazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about In vitro activities of position 2 substitution-bearing 6-nitro- and 6-amino-benzothiazoles and their corresponding anthranilic acid derivatives against Leishmania infantum and Trichomonas vaginalis. Author is Delmas, Florence; Di Giorgio, Carole; Robin, Maxime; Azas, Nadine; Gasquet, Monique; Detang, Claire; Costa, Muriel; Timon-David, Pierre; Galy, Jean-Pierre.

6-Nitro- and 6-amino-benzothiazoles bearing different chains in position 2 and their corresponding anthranilic acid derivatives were investigated for their in vitro antiparasitic properties against parasites of the species Leishmania infantum and Trichomonas vaginalis compared to their toxicity towards human monocytes. Biol. investigations established that the antiprotozoal properties depended greatly on the chem. structure of the position 2 substitution-bearing group. Compound C1, 2-[(2-chloro-benzothiazol-6-yl) amino] benzoic acid, demonstrated an interesting antiproliferative activity towards parasites of the species T. vaginalis, while compound C11, 2-({2-[(2-hydroxyethyl) amino]-benzothiazol-6-yl} amino) benzoic acid, exhibited a promising activity against parasites of the species L. infantum in their intracellular amastigote form. Addnl. experiments established that compound C11, which was poorly toxic against the promastigote and the extracellular amastigote forms of the parasite, could improve host-protective mechanisms against Leishmania by preventing parasite internalization by macrophages and stimulating NO production, by a mechanism synergistically enhanced by the presence of gamma interferon.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogen effect on the nucleophilic reactivity of 2-halobenzothiazoles》. Authors are Todesco, P. E.; Vivarelli, P..The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Synthetic Route of C7H3ClN2O2S. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

The rate of the substitution reactions of 2-chloro- (I), 2-bromo-(II), 2-fluoro- (III), 2-chloro-6-nitro- (IV), and 2-bromo-6-nitrobenzothiazole (V) with MeONa (VI) and PhSNa (VII) was calculated at 25° as K × 103. Thus, I and VI had K = 0.55 and similarly: I + VII, 0.20; II + VI, 0.41; II + VII, 0.44; III + VI, 550; III + VII, ≥1000; IV + VI, 278; IV + VII, 1660; V + VI, 152; V + VII, 2550. The results obtained showed that the reaction rates of 2-chloro and 2-bromo derivatives are similar but markedly lower than that of 2-fluoro derivatives In the case of the 2 halo-6-nitro derivatives, VII seemed more nucleophilic than VI.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Verma, Sanjeev K.; Ghorpade, Ramarao; Kaushik, M. P. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Safety of 2-Chloro-6-nitrobenzo[d]thiazole.They published the article 《Arylation of Amines and Monoarylation of Symmetrical Diamines in the Presence of Brine Solution with Diheteroaryl Halides》 about this compound( cas:2407-11-6 ) in Synthetic Communications. Keywords: arylamine preparation; monoaryldiamine preparation; amine aryl halide arylation phase transfer catalyst. We’ll tell you more about this compound (cas:2407-11-6).

A simple, scalable, ligand-free, and metal-free protocol for arylation of amines and monoarylation of sym. diamines with diheteroaryl halides in the presence of brine solution has been developed. The protocol has broad structural applicability for chemoselective monoarylation of a wide variety of sym., cyclic, and acyclic aliphatic diamines. The protocol is also applicable for selective arylation of aliphatic amine in the presence of aromatic amine.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Synthetic Route of C7H3ClN2O2S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Synthesis and characterization of N-substituted phenyl-N’-(2- chlorobenzothiazol-6-yl)urea.

Seven compounds of N-(R-phenyl)-N’-(2-chlorobenzothiaxol-6- yl)urea I (R = H, m-Cl, p-Cl, m-Me, p-Me, m-NO2, or p-NO2) were synthesized in 5 steps via condensation of 2-chloro-6-aminobenzothiazole and substituted Ph isocyanate with over all yield 74-88%. The structures of the synthetic compounds were characterized by elemental anal., 1HNMR, and IR.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Chloro-6-nitrobenzo[d]thiazole(SMILESS: O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-],cas:2407-11-6) is researched.Electric Literature of C24H40N4O4Rh2. The article 《Synthesis of a few substituted 3-mercapto-s-triazolo[3,4-b]benzothiazoles》 in relation to this compound, is published in Journal of the Indian Chemical Society. Let’s take a look at the latest research on this compound (cas:2407-11-6).

The benzothiazole I (R = NH2, R1 = NO2) underwent Sandmeyer reaction and the resultant I (R = Cl, R1 = NO2) was treated with H2NNH2.H2O to give I (R = H2NNH, R1 = NO2), which was cyclized with CS2 and the product triazolobenzothiazole II (R1 = NO2, R2 = H) treated with EtI to give II (R1 = NO2, R2 = Et). II (R1 = Cl; R2 = Et, Me) were similarly prepared II had antitumor activity (no data).

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of heterocyclic compounds of nitrogen. XXI. 2-Chloro-6-nitrobenzothiazole》. Authors are Takahashi, Torizo; Taniyama, Hyozo.The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Safety of 2-Chloro-6-nitrobenzo[d]thiazole. Through the article, more information about this compound (cas:2407-11-6) is conveyed.

The NO2 group in 1 isomer of nitro-2-mercaptobenzothiazole (I), obtained by the nitration of 2-mercaptobenzothiazole, was proved to be at the 6-position by the following method. I with PCl5 and POCl3 gave nitro-2-chlorobenzothiazole (II), yellow needles, m. 190-1°. 2-Amino-6-nitrobenzothiazole, yellow needles, m. 245°, was prepared from p-nitroaniline, (NH4)2SCN, and Br, diazotized and decomposed to 2-chloro-6-nitrobenzothiazole, yellow needles, m. 189-90°, identical with II; it can be concluded that I was 2-mercapto-6-nitrobenzothiazole. II can also be obtained by the nitration of 2-chlorobenzothiazole.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Diazotization of 2,6-diaminobenzothiazole. A new process for the preparation of 2-chlorobenzothiazole reactive azo dyes, published in 1993, which mentions a compound: 2407-11-6, Name is 2-Chloro-6-nitrobenzo[d]thiazole, Molecular C7H3ClN2O2S, Product Details of 2407-11-6.

The diazotization of 2,6-diaminobenzothiazole was studied. The two amino groups could be diazotized in HCl to yield a 2-chlorobenzothiazole-6-diazonium intermediate when reacted in a standard manner. A small comparative study on the diazotization of 6-substituted 2-aminobenzothiazoles using these standard conditions was presented. The usefulness of the reaction for the preparation of 2-chlorobenzothiazole reactive dyes was outlined.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI