Category: 2407-11-6

Computed Properties of C7H3ClN2O2S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition. Author is Garzon, Miguel; Arce, Elsa M.; Reddy, Raju Jannapu; Davies, Paul W..

A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl-imidazole family of heteroaromatics was developed. New types of heteroatom substituted carbimidoyl nitrenoids were efficiently realized from robust, bench-stable N-(heteroaryl)-pyridinium-N-aminides by formal gold-catalyzed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allowed rapid access into diverse functionalized scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Forlani, Luciano; Todesco, Paolo E. researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Safety of 2-Chloro-6-nitrobenzo[d]thiazole.They published the article 《Base catalysis in reactions between 2-halo-6-nitrobenzothiazoles and aliphatic amines in benzene. Part II》 about this compound( cas:2407-11-6 ) in Gazzetta Chimica Italiana. Keywords: benzothiazole halonitro amine substitution; substitution halonitrobenzothiazole amine catalysis. We’ll tell you more about this compound (cas:2407-11-6).

Rate data for reactions of I (X = Br, Cl) with amines (e.g. piperidine, BuNH2, Me3CNH2) show the presence of a base-catalyzed pathway which involves bifunctional catalysis, basic on the entering group, acidic on the leaving group.

The article 《Base catalysis in reactions between 2-halo-6-nitrobenzothiazoles and aliphatic amines in benzene. Part II》 also mentions many details about this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole, you can pay attention to it, because details determine success or failure

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

SDS of cas: 2407-11-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Synthesis and tautomerism of O-heteryl derivatives of tropolone. Author is Kurbatov, S. V.; Budarina, Z. N.; Zhdanov, Yu. A.; Olekhnovich, L. P..

Trimethyltropolone O-heteryl derivatives I (R = 6-nitro-2-benzothiazolyl, 5-nitro-2-pyrimidinyl, or 4,6-dichloro-1,3,5-triazin-2-yl) were prepared and O ⇄ O’ migration of the heteryl R groups studied by temperature-dependent NMR. Migration capabilities of the R groups increased in their stated order.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.Safety of 2-Chloro-6-nitrobenzo[d]thiazole.

With the aim to develop new chem. tools based on simplified natural metabolites to help deciphering the mol. mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Compounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein. This article reports the design, synthesis and biol. evaluation of a series of 2-aminobenzazoles on the necroptotic cell death through the inhibition of RIPK1 protein kinase. The 2-aminobenzimidazole and 2-aminobenzothiazole platforms presented herein can serve as novel chem. tools to study the mol. regulation of necroptosis and further develop lead drug candidates for chronic pathologies involving necroptosis.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Xu, Han; Hu, Xu-hong; Zou, Xiao-mao; Zhu, You-quan; Liu, Bin; Hu, Fang-zhong; Yang, Hua-zheng published the article 《Synthesis and Herbicidal Activity of 5-Heterocycloxy-3-substituted-l-(3-trifluoromethyl)phenyl-1H-pyrazole》. Keywords: herbicide pyrazole benzoxazole benzothiazole pyrimidine preparation phytoene desaturase.They researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).Category: ruthenium-catalysts. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2407-11-6) here.

The authors synthesized a series of novel 5-heterocycloxy-3-substituted-1-[(3-trifluoromethyl)phenyl]-1H-pyrazole derivatives The herbicidal activity of two intermediate compounds and thirteen target compounds were evaluated against Brassica napus and Echinochloa crus-galli (L.) Beauv tests. Bioassay results show that some of the compounds exhibit better inhibiting activities against Brassica napus and some of the compounds exhibit bleaching activities against Echinochloa crus-galli (L.) Beauv at 100 μg/mL. The title compounds thus formed included a [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]benzoxazole derivative (I) and related substances, such as [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]benzothiazole derivatives and [[[(trifluoromethyl)phenyl]pyrazolyl]oxy]pyrimidine derivatives The synthesis of the target compounds was achieved using 2,4-dihydro-5-methyl-2-[3-(trifluoromethyl)phenyl]-3H-pyrazol-3-one and 2,4-dihydro-5-(trifluoromethyl)-2-[3-(trifluoromethyl)phenyl]-3H-pyrazol-3-one (and its enol isomer) as key intermediates.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Bao; You, Qi Dong; Li, Zhi Yu researched the compound: 2-Chloro-6-nitrobenzo[d]thiazole( cas:2407-11-6 ).COA of Formula: C7H3ClN2O2S.They published the article 《Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives》 about this compound( cas:2407-11-6 ) in Chinese Chemical Letters. Keywords: quinolinecarbonitrile preparation antitumor neoplasm. We’ll tell you more about this compound (cas:2407-11-6).

Twelve new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitriles I (R1 = H2N, Me2N, Et2N; R2 = Et2N, N-piperidinyl, N-morpholinyl, etc.) were synthesized. The cytotoxicity of the new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. Several synthesized compounds displayed more potent cytotoxic activities than Bosutinib. Compound I (R1 = R2 = Et2N) exhibited the most potent antitumor activity among the tested compounds

After consulting a lot of data, we found that this compound(2407-11-6)COA of Formula: C7H3ClN2O2S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents, published in 2005-07-15, which mentions a compound: 2407-11-6, mainly applied to benzothiazolediamine preparation antitumor, Application of 2407-11-6.

Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid [2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide, which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (I) was designed and synthesized as a biol. stable derivative containing no nitro group. The highly potent derivative I exhibited excellent in vivo inhibitory effect on tumor growth.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organic Chemistry called Reactions in the thiazole series. I. Reactions of 2-chlorobenzothiazoles with thioureas, Author is Scott, Winfield; Watt, George W., which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Product Details of 2407-11-6.

N-Methylenecyclohexylamine, melted on the water bath and treated with S in small portions, gives 37% of s-dicyclohexylthiourea (I), m. 179-80°; various modifications of the reaction did not materially increase the yield (maximum, 44%). The reaction of 1,1′-methylenebispiperidine and S in xylene did not give the expected s-dipentamethylenethiourea but there resulted 34% of piperidine pentamethylenedithiocarbamate, m. 172-3°, piperidine hydrosulfide, H2S and varying amounts of tarry products. The reaction of 2-chlorobenzothiazole (II) with thiourea, the allyl, Ph and o-tolyl derivatives gave 100, 100, 78 and 79%, resp., of 2-mercaptobenzothiazole (III); no reaction occurred with s-diphenyl- N,N-dimethyl-N’-phenyl-(IV), N,N-pentamethylene-N’-phenyl derivatives and I. II and N,N’-o-phenylenethiourea give the addition compound, C14H10ClN3S2, m. 233-4° (decomposition), in 86% yield when refluxed 1 hr. in EtOH. The yield of the 6-NO2 derivative of III, m. 225-7°, from the 6-NO2 derivative of II was: thiourea 100, allyl- 94, Ph-92, o-tolyl 93, s-di-Pr 49, I 94°, IV 0. A by-product in the reaction with IV is 2-dimethylamino-6-nitrobenzothiazole, m. 197.5-9°; Me2NH is probably formed by the decomposition of IV. The order of decreasing reactivity is thiourea > mono- > di- > trisubstituted.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Pubbl. ist. chim. univ. Bologna called Benzothiazole. V. The mobility of the chlorine atom in 2-chloro-6-nitrobenzothiazole, Author is Colonna, M.; Andrisano, R., which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Computed Properties of C7H3ClN2O2S.

The mobility of the Cl atom in IV is greater than that of Cl in II, and probably it is influenced by the presence of the NO2 group in position 6. The following reactions take place very easily and with nearly theoretical yields. IV, treated with PhNH2, gives 2-anilino-6-nitrobenzothiazole, C13H9N3O2S, yellow crystals, m. 247° (cf. Hoffmann, Ber. 13, 12(1880)); with NH2NH2, the 2-hydrazino derivative C7H6N4O2S, yellow needles, m. 243-4° (decomposition) (benzaldehyde hydrazone, C14H10N4O2S, yellow needles (from dioxane), m. 275°; acetophenone hydrazone, C15H12N4O2S, yellow prisms (from dioxane), m. 266° (partial decomposition); tetrazole derivative, C7H3N5O2S, yellow plates becoming brown in the light and decomposing 158°); with piperidine, the 2-piperidyl derivative, C12H13N3O2S, lemon-yellow needles (from EtOH), m. 170°; with p-aminobiphenyl, the 2-(p-biphenylylamino) derivative, C19H13N3O2S, orange precipitate, m. 165°; with p-anisidine the 2-(p-anisidino) derivative, C14H11N3O2S, yellow needles (from dioxane), m. 282°, with p-phenetidine, the 2-(p-phenetidino) derivative, C15H13N3O2S, yellow needles (from dioxane), m. 235°.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application In Synthesis of 2-Chloro-6-nitrobenzo[d]thiazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Effective induction of β-selectivity using α- or β-mannosyl 6-nitro-2-benzothiazoate in mannosylation. Author is Hashihayata, Takashi; Mukaiyama, Teruaki.

Highly β-selective mannosylations of glycosyl acceptors with an α-mannosyl 6-nitro-2-benzothiazoate donor (I) were carried out smoothly in the presence of a catalytic amount of tetrakis(pentafluorophenyl)boric acid [HB(C6F5)4] to afford the corresponding disaccharides in good to high yields: it was proved that high β-selectivity was entirely dependent on the characteristic properties of a donor I and a catalyst, HB(C6F5)4. Interestingly, it was observed that in situ anomerization from 1β to 1α took place rapidly when β-mannosyl donor was treated with a catalytic amount of HB(C6F5)4 in CH2Cl2.

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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI