Category: 23856-20-4

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry.Formula: C14H11N3O2.

Potassium fluoride-impregnated on alumina catalyzes a solvent-free regioselective O-benzylation, benzoylation and cinnamylation of phenols. Reaction proceeds simply by triturating together equivalent amounts of phenol and corresponding halide in the presence of 5 mol% of KF/alumina for 5-20 min with a mortar and pestle, without need for any additive, such as a phase-transfer catalyst or solvent. Key features of the protocol include its efficiency also for solid-solid precursors and regioselectivity for phenolic hydroxyl groups vs. alc. hydroxy groups. Utility of the protocol for N- and S-benzylation has also been explored. Products were obtained in excellent yields and the catalyst can be easily recycled several times without significant loss of activity. The synthesis of the target compounds was achieved using 5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-2-methyl-4H-1-benzopyran-4-one (chromene alkaloid rohitukine) was a starting material. The title compounds thus formed included benzyl ethers, such as a rohitukine methoxybenzyl ether (I).

After consulting a lot of data, we found that this compound(23856-20-4)Formula: C14H11N3O2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Application In Synthesis of 1-Benzyl-5-nitro-1H-indazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors. Author is Milik, Sandra N.; Abdel-Aziz, Amal Kamal; Lasheen, Deena S.; Serya, Rabah A. T.; Minucci, Saverio; Abouzid, Khaled A. M..

In light of the emergence of resistance against the currently available EGFR inhibitors, our study focuses on tackling this problem through the development of dual EGFR/HER2 inhibitors with improved enzymic affinities. Guided by the binding mode of the marketed dual EGFR/HER2 inhibitor, Lapatinib, we proposed the design of dual EGFR/HER2 inhibitors based on the 6-phenylthieno[2,3-d]pyrimidine as a core scaffold and hinge binder. After two cycles of screening aiming to identify the optimum aniline headgroup and solubilizing group, we eventually identified 27b as a dual EGFR/HER2 inhibitor with IC50 values of 91.7 nM and 1.2 μM, resp. Notably, 27b dramatically reduced the viability of various patient-derived cancer cells preferentially overexpressing EGFR/HER2 (A431, MDA-MBA-361 and SKBr3 with IC50 values of 1.45, 3.5 and 4.83 μM, resp.). Addnl., 27b efficiently thwarted the proliferation of lapatinib-resistant human non-small lung carcinoma (NCI-H1975) cells, harboring T790 M mutation, with IC50 of 4.2 μM. Consistently, 27b significantly blocked EGF-induced EGFR activation and inactivated its downstream AKT/mTOR/S6 signalling pathway triggering apoptotic cell death in NCI-H1975 cells. The present study presents a promising candidate for further design and development of novel EGFR/HER2 inhibitors capable of overcoming EGFR TKIs resistance.

Although many compounds look similar to this compound(23856-20-4)Application In Synthesis of 1-Benzyl-5-nitro-1H-indazole, numerous studies have shown that this compound(SMILES:C(C1=CC=CC=C1)[N]3C2=CC=C(C=C2C=N3)[N+](=O)[O-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C14H11N3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives. Author is Zhang, Fan; Zhai, Xin; Chen, Li-Juan; Qi, Jian-Guo; Cui, Bo; Gu, Yu-Cheng; Gong, Ping.

2,5-Disubstituted pyrimido[5,4-c]quinolines were synthesized, and their cytotoxic activity against H460, HT-29, and MDA-MB-231 cell lines was evaluated in vitro. Most of the tested compounds showed stronger activity to the selected cell lines than ZM447439.

Compounds in my other articles are similar to this one(1-Benzyl-5-nitro-1H-indazole)Formula: C14H11N3O2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Recommanded Product: 1-Benzyl-5-nitro-1H-indazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about A General, One-Step Synthesis of Substituted Indazoles using a Flow Reactor. Author is Wheeler, Rob C.; Baxter, Emma; Campbell, Ian B.; MacDonald, Simon J. F..

Flow chem. is a rapidly emerging technol. within the pharmaceutical industry, both within medicinal and development chem. groups. The advantages of flow chem., increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technol. in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilizes flow chem. to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogs.

Compounds in my other articles are similar to this one(1-Benzyl-5-nitro-1H-indazole)Recommanded Product: 1-Benzyl-5-nitro-1H-indazole, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Quality Control of 1-Benzyl-5-nitro-1H-indazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach. Author is Lategahn, Jonas; Hardick, Julia; Grabe, Tobias; Niggenaber, Janina; Jeyakumar, Kirujan; Keul, Marina; Tumbrink, Hannah L.; Becker, Christian; Hodson, Luke; Kirschner, Tonia; Kloevekorn, Philip; Ketzer, Julia; Baumann, Matthias; Terheyden, Susanne; Unger, Anke; Weisner, Joern; Mueller, Matthias P.; van Otterlo, Willem A. L.; Bauer, Sebastian; Rauh, Daniel.

Mutated or amplified Her2 serves as a driver of non-small cell lung cancer or mediates resistance toward the inhibition of its family member epidermal growth factor receptor with small-mol. inhibitors. To date, small-mol. inhibitors targeting Her2 which can be used in clin. routine are lacking, and therefore, the development of novel inhibitors was undertaken. In this study, the well-established pyrrolopyrimidine scaffold was modified with structural motifs identified from a screening campaign with more than 1600 compounds, which were applied against wild-type Her2 and its mutant variant Her2-A775_G776insYVMA. The resulting inhibitors were designed to covalently target a reactive cysteine in the binding site of Her2 and were further optimized by means of structure-based drug design utilizing a set of obtained complex crystal structures. In addition, the anal. of binding kinetics and absorption, distribution, metabolism, and excretion parameters as well as mass spectrometry experiments and western blot anal. substantiated our approach.

When you point to this article, it is believed that you are also very interested in this compound(23856-20-4)Quality Control of 1-Benzyl-5-nitro-1H-indazole and due to space limitations, I can only present the most important information.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23856-20-4, is researched, SMILESS is C(C1=CC=CC=C1)[N]3C2=CC=C(C=C2C=N3)[N+](=O)[O-], Molecular C14H11N3O2Journal, Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk called Relation between the electronic structure and the radioprotectant activity of some indazoles, Author is Sokolov, Yu. A., the main research direction is electronic structure radioprotectant indazole derivative.Electric Literature of C14H11N3O2.

Quantum chem. MNDO study of electronic structure for 29 indazoles has been performed. Statistically significant relation between some characteristics obtained and radioprotective activity was found out. Indazole structures which data predicted for radioprotective activity (survival, %) are on 50% level or more are proposed.

There are many compounds similar to this compound(23856-20-4)Electric Literature of C14H11N3O2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity, published in 2005-02-24, which mentions a compound: 23856-20-4, mainly applied to quinolinecarbonitrile arylamino preparation inhibitor HER2 EGFR kinase antitumor; quinoline cyano arylamino preparation inhibitor HER2 EGFR kinase antitumor; human epidermal growth factor receptor kinase inhibitor irreversible preparation, Electric Literature of C14H11N3O2.

A series of new 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles, e.g. I (R1 = H, Cl; R2 = PhCH2O, 1-imidazolyl, 2-furylmethoxy, etc.; R3 = Cl, CN, PhCH2O; R4 = Me, Et; R5 = Me, R6 = Me, HOCH2CH2; R5R6N = azetidinyl, piperidinyl, thiomorpholinyl, etc.) that function as irreversible inhibitors of human epidermal growth factor receptor-2 (HER-2) and epidermal growth factor receptor (EGFR) kinases have been prepared These compounds demonstrated enhanced activities for inhibiting HER-2 kinase and the growth of HER-2 pos. cells compared to the EGFR kinase inhibitor I [R1 = H; R2 = F; R3 = Cl; R4 = Et; R5 = R6 = Me; (EKB-569)]. Three synthetic routes were used to prepare these compounds They were prepared mostly by acylation of 6-amino-4-(arylamino)quinoline-3-carbonitriles with unsaturated acid chlorides or by amination of 4-chloro-6-(crotonamido)quinoline-3-carbonitriles with monocyclic or bicyclic anilines. The third route was developed to prepare a key intermediate, 6-acetamido-4-chloroquinoline-3-carbonitrile, that involved a safer cyclization step. It was shown that attaching a large lipophilic group at the para position of the 4-(arylamino) ring results in improved potency for inhibiting HER-2 kinase. The importance of a basic dialkylamino group at the end of the Michael acceptor for activity, due to intramol. catalysis of the Michael addition has also been demonstrated. This, along with improved water solubility, resulted in compounds with enhanced biol. properties. The mol. modeling results consistent with the proposed mechanism of inhibition are presented. Binding studies of one compound, I [R1 = H; R2 = 2-pyridylmethoxy; R3 = Cl; R4 = Et; R5 = R6 = Me; (HKI-272)] (C-14 radiolabeled), showed that it binds irreversibly to HER-2 protein in BT474 cells. Furthermore, it demonstrated excellent oral activity, especially in HER-2 overexpressing xenografts. Compound HKI-272 was selected for further studies and is currently in phase I clin. trials for the treatment of cancer.

Here is just a brief introduction to this compound(23856-20-4)Electric Literature of C14H11N3O2, more information about the compound(1-Benzyl-5-nitro-1H-indazole) is in the article, you can click the link below.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Formula: C14H11N3O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Relation between structure and the antiinflammatory and analgesic activities of some aminoindazole derivatives. Author is Granger, Robert; Koeberle, J.; Le-Hao-Dong; Boucard, M.; Giroux, J. J.; Mizoule, J.; Yavordios, D..

Of the 12 aminoindazole derivatives studied, the 5-aminoindazoles had the highest antiinflammatory activity in rats with induced edema, and analgesic activity in mice. 1-Benzoyl-5-aminoindazole-HCl, the most interesting of the compounds studied, had a 50% effective dose of 100 mg/kg and 125 mg/kg in rats with Carrageenin-induced edema and kaolin-induced edema, resp. The hydrochloride (100 mg/kg/day, for 11 days) inhibited in vivo granuloma growth by 32%. In the rat, the antipyretic activity was equal to ∼40% of the activity obtained with an equal dose of acetylsalicyclic acid.

I hope my short article helps more people learn about this compound(1-Benzyl-5-nitro-1H-indazole)Formula: C14H11N3O2. Apart from the compound(23856-20-4), you can read my other articles to know other related compounds.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cockerill, S.; Stubberfield, C.; Stables, J.; Carter, M.; Guntrip, S.; Smith, K.; McKeown, S.; Shaw, R.; Topley, P.; Thomsen, L.; Affleck, K.; Jowett, A.; Hayes, D.; Willson, M.; Woollard, P.; Spalding, D. researched the compound: 1-Benzyl-5-nitro-1H-indazole( cas:23856-20-4 ).SDS of cas: 23856-20-4.They published the article 《Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2》 about this compound( cas:23856-20-4 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: tyrosine kinase receptor inhibitor indazolylaminopyridopyrimidine preparation. We’ll tell you more about this compound (cas:23856-20-4).

Described herein is the design and synthesis of indazolylaminopyridopyrimidines and quinazolines as inhibitors of the class 1 tyrosine kinase receptor family. Data is presented for N4-(1-benzyl-1H-indazol-5-yl)-N6,N6-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine. This compound inhibited EGFr and c-erbB-2 enzymes selectively over other kinases. It inhibited the proliferation of a range of tumor cell lines in vitro and the growth of BT474 xenografts in SCID mice. The identification of the c-erbB-2/EGFr inhibitor GW974 is described.

Here is just a brief introduction to this compound(23856-20-4)SDS of cas: 23856-20-4, more information about the compound(1-Benzyl-5-nitro-1H-indazole) is in the article, you can click the link below.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Reference of 1-Benzyl-5-nitro-1H-indazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about A method for the regioselective synthesis of 1-alkyl-1H-indazoles. Author is Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey.

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles followed by reductive deamination.

Here is just a brief introduction to this compound(23856-20-4)Reference of 1-Benzyl-5-nitro-1H-indazole, more information about the compound(1-Benzyl-5-nitro-1H-indazole) is in the article, you can click the link below.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI