With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50982-12-2,Dichloro(cycloocta-1,5-diene)ruthenium(II),as a common compound, the synthetic route is as follows.
A nitrogen-flushed three-neck flask was charged with 65.36 g of ruthenium trichloride trihydrate, 500 mL of ethanol and 250 mL of 1,5-cyclooctadiene, and the flask contents were refluxed under heating at 85 C. for 5 hours. Following the completion of refluxing, the solution was cooled to room temperature, after which filtration was carried out. The resulting solid was washed with 500 mL of diethyl ether and dried in vacuo, yielding 70.02 g of (eta-1,5-cyclooctadiene)ruthenium(II) dichloride as a brown solid. Next, 2.81 g of this (eta-1,5-cyclooctadiene)ruthenium(II) dichloride, 6.38 g of sodium carbonate, 2.9 mL of methyl 3-oxo-4,4,4-trifluorobutanoate and 10 mL of ethanol were placed in a nitrogen-flushed three-neck flask and refluxed under heating at 85 C. for 2 hours. Following the completion of refluxing, the solution was cooled to room temperature, then alumina column chromatography (developing solvent: acetone) was carried out. The resulting solution was concentrated and dried under reduced pressure, and 3.61 g of bis(methyl-3-oxo-4,4,4-trifluorobutanato)(eta-1,5-cyclooctadiene)ruthenium(II) was obtained as a black reddish-brown liquid. The yield was 66 wt %.
The synthetic route of 50982-12-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JSR Corporation; US2012/282414; (2012); A1;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI