So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hesp, Kevin D.; Lundgren, Rylan J.; Stradiotto, Mark researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Safety of 1-Boc-4-Bromoindole.They published the article 《Palladium-Catalyzed Mono-α-arylation of Acetone with Aryl Halides and Tosylates》 about this compound( cas:676448-17-2 ) in Journal of the American Chemical Society. Keywords: aryl methyl ketone preparation; arylhalide acetone monoarylation palladium catalyst. We’ll tell you more about this compound (cas:676448-17-2).
The first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates is reported. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs2CO3 as the base and employing acetone as both a reagent and the solvent.
Although many compounds look similar to this compound(676448-17-2)Safety of 1-Boc-4-Bromoindole, numerous studies have shown that this compound(SMILES:C(C)(C)(C)OC(=O)[N]2C1=CC=CC(=C1C=C2)Br), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI