The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology》. Authors are Uto, Yoshikazu.The article about the compound:1,2-Benzisoxazolecas:271-95-4,SMILESS:C12=CC=CC=C1ON=C2).Recommanded Product: 1,2-Benzisoxazole. Through the article, more information about this compound (cas:271-95-4) is conveyed.
A review. Background: Privileged structures are potentially able to bind to a diverse range of biol. important proteins with high affinities, thus benefiting the discovery of novel bioactive compounds 1,2-Benxisoxazole derivatives can be such important types of “”privileged structures”” possessing a rich diversity of biol. properties especially in the area of CNS disorders. Methods: This review seeks to explore the most significant examples of 1,2-benzisoxazoles as privileged structures in terms of polypharmacol. at the mol. level, specifically focusing on four 1,2-benzisoxazoles (zonisamide, risperidone, paliperidone, and iloperidone) which have been in clin. use and established as effective therapeutics. Furthermore, an updated and detailed account of the pharmacol. properties of 1,2-benzisoxazole derivatives as therapeutics for CNS disorders is described. And finally, outlooks on current issues and future directions in this field are also provided. Results: 1,2-Benzisoxazole was successfully employed in the discovery and development of zonisamide for the treatment of epilepsy and Parkinson’s disease. 1,2- Benzisoxazole is also a significantly important structure for the development of atypical antipsychotics. Conclusion: It is very reasonable to say that 1,2-benzisoxazole is a good example of a privileged structure because it forms the centerpiece of small mol. chem. entities with a wide range of pharmacol. properties, especially in the area of CNS disorders.
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