So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cockerill, S.; Stubberfield, C.; Stables, J.; Carter, M.; Guntrip, S.; Smith, K.; McKeown, S.; Shaw, R.; Topley, P.; Thomsen, L.; Affleck, K.; Jowett, A.; Hayes, D.; Willson, M.; Woollard, P.; Spalding, D. researched the compound: 1-Benzyl-5-nitro-1H-indazole( cas:23856-20-4 ).SDS of cas: 23856-20-4.They published the article 《Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and c-erbB-2》 about this compound( cas:23856-20-4 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: tyrosine kinase receptor inhibitor indazolylaminopyridopyrimidine preparation. We’ll tell you more about this compound (cas:23856-20-4).
Described herein is the design and synthesis of indazolylaminopyridopyrimidines and quinazolines as inhibitors of the class 1 tyrosine kinase receptor family. Data is presented for N4-(1-benzyl-1H-indazol-5-yl)-N6,N6-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine. This compound inhibited EGFr and c-erbB-2 enzymes selectively over other kinases. It inhibited the proliferation of a range of tumor cell lines in vitro and the growth of BT474 xenografts in SCID mice. The identification of the c-erbB-2/EGFr inhibitor GW974 is described.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI