Top Picks: new discover of Cis-Dichlorobis(2,2′-bipyridine)ruthenium(II)

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In an article, published in an article, once mentioned the application of 15746-57-3, Name is Cis-Dichlorobis(2,2′-bipyridine)ruthenium(II),molecular formula is C20H16Cl2N4Ru, is a conventional compound. this article was the specific content is as follows.COA of Formula: C20H16Cl2N4Ru

A small library of 17 organoruthenium compounds with the general formula [RuII(fcl)(chel)(L)]n+ (in which fcl=face capping ligand, chel=chelating bidentate ligand, and L=monodentate ligand) were screened for inhibitory activity against cholinesterases and glutathione-S-transferases of human and animal origins. Compounds were selected to include different chelating ligands (i.e., N,N-, N,O-, O,O-, S,O-) and monodentate ligands that can modulate the aquation rate of the metal species. Compounds with a labile ruthenium chloride bond that provided rapid aquation were found to inhibit both sets of enzymes in reversible competitive modes and at pharmaceutically relevant concentrations. When applied at concentrations that completely abolish the activity of human acetylcholinesterase, the lead compound [(eta6-p-cymene)Ru(pyrithionato)Cl] (C1 a) showed no undesirable physiological responses on the neuromuscular system. Finally, C1 a was not cytotoxic against non-transformed cells at pharmaceutically relevant concentrations.

Do you like my blog? If you like, you can also browse other articles about this kind. COA of Formula: C20H16Cl2N4Ru. Thanks for taking the time to read the blog about 15746-57-3

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI