Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 37366-09-9, C12H12Cl4Ru2. A document type is Article, introducing its new discovery., COA of Formula: C12H12Cl4Ru2
The new RuII chloroquine complexes [Ru(eta6-arene) (CQ)Cl2] (CQ = chloroquine; arene = p-cymene 1, benzene 2), [Ru(eta6-p-cymene)(CQ)(H2O)2][BF 4]2 (3), [Ru(eta6-p-cymene)(CQ)(en)][PF 6]2 (en = ethylenediamine) (4), and [Ru(eta6- p-cymene)(eta6-CQDP)][BF4]2 (5, CQDP = chloroquine diphosphate) have been synthesized and characterized by use of a combination of NMR and FTIR spectroscopy with DFT calculations. Each complex is formed as a single coordination isomer: In 1-4, chloroquine binds to ruthenium in the eta1-N mode through the quinoline nitrogen atom, whereas in 5 an unprecedented eta6 bonding through the carbocyclic ring is observed. 1, 2, 3, and 5 are active against CQ-resistant (Dd2, K1, and W2) and CQ-sensitive (FcB1, PFB, F32, and 3D7) malaria parasites (Plasmodium falciparum); importantly, the potency of these complexes against resistant parasites is consistently higher than that of the standard drug chloroquine diphosphate. 1 and 5 also inhibit the growth of colon cancer cells, independently of the p53 status and of liposarcoma tumor cell lines with the latter showing increased sensitivity, especially to 1 (IC50 8 muM); this is significant because this type of tumor does not respond to currently employed chemotherapies.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI