Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 37366-09-9, C12H12Cl4Ru2. A document type is Article, introducing its new discovery., Safety of Dichloro(benzene)ruthenium(II) dimer
New ruthenium(II)-letrozole complexes as anticancer therapeutics
Novel ruthenium-letrozole complexes have been prepared, and cell viability of two human cancer cell types (breast and glioblastoma) was determined. Some ruthenium compounds are known for their cytotoxicity to cancer cells, whereas letrozole is an aromatase inhibitor administered after surgery to post-menopausal women with hormonally responsive breast cancer. A significant in vitro activity was established for complex 5¡¤Let against breast cancer MCF-7 cells and significantly lower activity against glioblastoma U251N cells. The activity of 5¡¤Let was even higher than that of 4, a compound analogous to the well-known drug RAPTA-C. Results from the combination of 5¡¤Let (or 4) with 3-methyladenine (3-MA) or with curcumin, respectively, revealed that the resultant cancer cell death likely involves 5¡¤Let-induced autophagy.
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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI