Hollfelder, Florian; Kirby, Anthony J.; Tawfik, Dan S. published the article 《Efficient Catalysis of Proton Transfer by Synzymes》. Keywords: catalysis proton transfer synzyme; synthetic enzyme proton transfer catalysis.They researched the compound: 1,2-Benzisoxazole( cas:271-95-4 ).Related Products of 271-95-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:271-95-4) here.
Enzyme catalysis depends on subtle combinations of effects that are difficult to sep. and quantify. Medium effects are a crucial part of this package, but the assignment of a local dielec. constant to the structured microenvironment of an active site and its effect on ground state destabilization or transition state stabilization by electrostatic interactions is exptl. impossible. We desire to mimic, and thus begin to quantify, such active site medium effects exptl. As a test reaction, we use the eliminative cleavage of benzisoxazole (Kemp elimination), known to be particularly sensitive to the effects of the medium. A subset of several hundred water-soluble polymers was prepared by alkylating polyethyleneimine (PEI) with different combination of three contrasting alkyl groups, forming enzyme-like catalysts (synzymes). These polymers catalyze the Kemp elimination, in water, with rate accelerations as high as 106 and at least 500 turnovers per basic site. Proton transfer from carbon is catalyzed by polymer amine groups with pKA values as low as 5.7 and apparent effective molarities of the order of 1000 M. Four of the synzymes combining high activity with sufficient solubility were selected for detailed characterization, including determination of kcat, KM, and pKA. The pH rate profile confirms that the catalytic species are active in their basic forms.
After consulting a lot of data, we found that this compound(271-95-4)Related Products of 271-95-4 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI