Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about KF/alumina catalyzed regioselective benzylation and benzoylation using solvent-free grind-stone chemistry.Formula: C14H11N3O2.
Potassium fluoride-impregnated on alumina catalyzes a solvent-free regioselective O-benzylation, benzoylation and cinnamylation of phenols. Reaction proceeds simply by triturating together equivalent amounts of phenol and corresponding halide in the presence of 5 mol% of KF/alumina for 5-20 min with a mortar and pestle, without need for any additive, such as a phase-transfer catalyst or solvent. Key features of the protocol include its efficiency also for solid-solid precursors and regioselectivity for phenolic hydroxyl groups vs. alc. hydroxy groups. Utility of the protocol for N- and S-benzylation has also been explored. Products were obtained in excellent yields and the catalyst can be easily recycled several times without significant loss of activity. The synthesis of the target compounds was achieved using 5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-2-methyl-4H-1-benzopyran-4-one (chromene alkaloid rohitukine) was a starting material. The title compounds thus formed included benzyl ethers, such as a rohitukine methoxybenzyl ether (I).
After consulting a lot of data, we found that this compound(23856-20-4)Formula: C14H11N3O2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI