Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Quinolin-6-ylboronic acid, is researched, Molecular C9H8BNO2, CAS is 376581-24-7, about A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities.Application In Synthesis of Quinolin-6-ylboronic acid.
A novel series of 4-Me substituted pyrazole derivatives were designed, synthesized and biol. evaluated as potent glucagon receptor (GCGR) antagonists. In this study, several compounds including (S)-3-(4-(1-(3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen2-yl)-4-methyl-1H-pyrazol-1-yl)ethyl)benzamido)propanoic acid, compound 9r (I), showed high GCGR binding (IC50 = 0.09 μM, 0.06 μM, 0.07 μM and 0.08 μM, resp.) and cyclic-adenosine monophosphate (cAMP) activities (IC50 = 0.22 μM, 0.26 μM, 0.44 μM and 0.46 μM, resp.) in cell-based assays. Most importantly, the docking experiment demonstrated that compound I formed extensive hydrophobic interactions with the receptor binding pocket, making it justifiable to further investigate the potential of becoming a GCGR antagonist.
Although many compounds look similar to this compound(376581-24-7)Application In Synthesis of Quinolin-6-ylboronic acid, numerous studies have shown that this compound(SMILES:OB(C1=CC=C2N=CC=CC2=C1)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI