The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ) is researched.Quality Control of 1-Boc-4-Bromoindole.Huang, David; Olivieri, Diego; Sun, Yang; Zhang, Pengpeng; Newhouse, Timothy R. published the article 《Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates》 about this compound( cas:676448-17-2 ) in Journal of the American Chemical Society. Keywords: nickel catalyst unactivated alkene difunctionalization enolate. Let’s learn more about this compound (cas:676448-17-2).
This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
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