Extracurricular laboratory: Synthetic route of 676448-17-2

Compounds in my other articles are similar to this one(1-Boc-4-Bromoindole)Synthetic Route of C13H14BrNO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Zhuo, Junming; Zhang, Yong; Li, Zijian; Li, Chao published the article 《Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles》. Keywords: ketone preparation; acylimidazole preparation aryl alkyl bromide acylation nickel catalyst; carboxylic acid carbonyldiimidazole cross coupling.They researched the compound: 1-Boc-4-Bromoindole( cas:676448-17-2 ).Synthetic Route of C13H14BrNO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:676448-17-2) here.

A modular method for the acylation of aryl and alkyl halides RBr (R = Ph, 2-methoxypyrimidin-5-yl, furan-3-yl, etc.) was reported. The transformation relies on acylimidazoles I (R1 = Ph, 2,2-dimethylpropyl, cyclopentylmethyl, naphthalen-2-yl, oxan-4-yl, etc.) and easy-to-prepare and flexible species derived from abundant carboxylic acids R1COOH as viable cross-coupling partners for the Ni-catalyzed acylation. Careful examination revealed a remarkable mechanism: the amide C-N bond of primary and secondary imidazolides I (R1 = pent-4-en-1-yl, cyclooct-4-en-1-yl, cyclopropylmethyl, etc.) can be activated by single-electron reduction, representing a major departure from other reported amide C-N bond activation reactions. Extensive mechanistic studies also revealed an intriguing CO-extrusion-recombination phenomenon. This cross-coupling reaction between two electrophiles features a broad substrate scope bearing a wide gamut of functionalities. The practicality of this atypical transformation was demonstrated in the synthesis of II (R2 = H, acetyl) and 1-(furan-3-yl)-4-methylpentan-1-one, which are difficult to access using traditional organometallic chem.

Compounds in my other articles are similar to this one(1-Boc-4-Bromoindole)Synthetic Route of C13H14BrNO2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI