The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromopropanenitrile( cas:19481-82-4 ) is researched.Application of 19481-82-4.Tang, Shan; Liu, Chao; Lei, Aiwen published the article 《Nickel-catalysed novel β,γ-unsaturated nitrile synthesis》 about this compound( cas:19481-82-4 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: unsaturated nitrile preparation; coupling alkene cyano alkyl bromide nickel catalyst. Let’s learn more about this compound (cas:19481-82-4).
Through a nickel-catalyzed Heck-type reaction, a direct coupling of alkenes with α-cyano alkyl bromides was achieved. This procedure provides a novel way for the synthesis of β,γ-unsaturated nitriles. E.g., in presence of Ni(PPh3)4 and dppp, reaction of 4-FC6H4CH:CH2 and PrCHBrCN gave 82% I as the (E)-isomer.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI