Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists, Author is Moriya, Minoru; Kishino, Hiroyuki; Sakuraba, Shunji; Sakamoto, Toshihiro; Suga, Takuya; Takahashi, Hidekazu; Suzuki, Takao; Ito, Masahiko; Ito, Junko; Moriya, Ryuichi; Takenaga, Norihiro; Iwaasa, Hisashi; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro, which mentions a compound: 2407-11-6, SMILESS is O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-], Molecular C7H3ClN2O2S, Safety of 2-Chloro-6-nitrobenzo[d]thiazole.
A series of 2-aminobenzimidazole-based MCH1R antagonists was identified by core replacement of the aminoquinoline lead 1. Subsequent modification of the 2- and 5-positions led to improvement in potency and intrinsic clearance. Compound 25 (I) exhibited good plasma and brain exposure, and attenuated MCH induced food intake at 30 mg/kg PO in rats.
As far as I know, this compound(2407-11-6)Safety of 2-Chloro-6-nitrobenzo[d]thiazole can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI