The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogen effect on the nucleophilic reactivity of 2-halobenzothiazoles》. Authors are Todesco, P. E.; Vivarelli, P..The article about the compound:2-Chloro-6-nitrobenzo[d]thiazolecas:2407-11-6,SMILESS:O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-]).Synthetic Route of C7H3ClN2O2S. Through the article, more information about this compound (cas:2407-11-6) is conveyed.
The rate of the substitution reactions of 2-chloro- (I), 2-bromo-(II), 2-fluoro- (III), 2-chloro-6-nitro- (IV), and 2-bromo-6-nitrobenzothiazole (V) with MeONa (VI) and PhSNa (VII) was calculated at 25° as K × 103. Thus, I and VI had K = 0.55 and similarly: I + VII, 0.20; II + VI, 0.41; II + VII, 0.44; III + VI, 550; III + VII, ≥1000; IV + VI, 278; IV + VII, 1660; V + VI, 152; V + VII, 2550. The results obtained showed that the reaction rates of 2-chloro and 2-bromo derivatives are similar but markedly lower than that of 2-fluoro derivatives In the case of the 2 halo-6-nitro derivatives, VII seemed more nucleophilic than VI.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Chloro-6-nitrobenzo[d]thiazole)Synthetic Route of C7H3ClN2O2S, illustrating the importance and wide applicability of this compound(2407-11-6).
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI