The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1,2-Benzisoxazole(SMILESS: C12=CC=CC=C1ON=C2,cas:271-95-4) is researched.HPLC of Formula: 271-95-4. The article 《Off-the-shelf proteins that rival tailor-made antibodies as catalysts》 in relation to this compound, is published in Nature (London). Let’s take a look at the latest research on this compound (cas:271-95-4).
Mimicking the efficiency of enzyme catalysis is a daunting challenge. An enzyme selectively binds and stabilizes the transition state(s) for a particular reaction. Artificial host systems can bind ground states just as efficiently, and rate enhancements comparable to those in enzymic reactions can be achieved by bringing catalytic and substrate groups together in intramol. reactions. But the combination of selective binding and efficient catalysis remains elusive. The best enzyme mimics currently known are catalytic antibodies. They bind transition-state analogs with high affinity, but their catalytic efficiency generally falls far short of that of enzymes. Thorn et al. recently described an antibody that catalyzes the eliminative ring-opening of a benzisoxazole “”exceptionally efficiently”” using carboxylate as the general base, raising the intriguing possibility that this high efficiency derives from precise positioning of catalytic and substrate groups. Familiar ‘off-the-shelf’ proteins-serum albumins-catalyze the same reaction at similar rates, using a lysine side-chain amino group as the catalytic general base. Comparisons suggest that formal general base catalysis is of only modest efficiency in both systems, and that the antibody catalysis is boosted by a non-specific medium effect.
Compound(271-95-4)Safety of 1,2-Benzisoxazole received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1,2-Benzisoxazole), if you are interested, you can check out my other related articles.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI