Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Macromolecular Science, Pure and Applied Chemistry called End group transformation of polymers prepared by ATRP, substitution to azides, Author is Coessens, Veerle; Matyjaszewski, Krzysztof, which mentions a compound: 19481-82-4, SMILESS is CC(Br)C#N, Molecular C3H4BrN, Application of 19481-82-4.
Polystyrenes, polyacrylates and poly(Me methacrylate) prepared by atom transfer radical polymerization (ATRP) have predictable mol. weights, low polydispersities and well-defined halogen end groups. The halogen end groups have been substituted by other functionalities such as azides and amines. In order to predict the feasibility and selectivity of nucleophilic substitution reactions, the reactivities of the end groups of the different polymers were studied. First, model studies with benzyl halide (BzX), 1-phenylethyl halide (1-PEX), Me 2-halopropionate (MXP), Et 2-bromoisobutyrate (EBiB) and 2-halopropionitrile (2-XPN) were performed. The models compounds were dissolved in DMF and after adding sodium azide (1.1 equivalent), the reaction mixtures were stirred at 25°C. The relative magnitude of the rate constants for the reactions with the chlorinated substrates were found to be BzCl > MClP > 1-PECL ≈ 2-ClPN:22 > 6 > 1. Increased substitution at the carbon center decreased the rate of reaction, benzyl chloride reacted 22 times faster than 1-phenylethyl chloride. The brominated substrates reacted very fast. The rate constant of 1-PEBr, determined by competition experiments, was 4.5 times higher than the rate constant of benzyl chloride. Based on these results, the bromine end groups of different polymers were substituted under reaction conditions similar to those used for the model reactions. The end-functionalized polymers were characterized by 1H-NMR, IR and MALDI-TOFMS.
I hope my short article helps more people learn about this compound(2-Bromopropanenitrile)Application of 19481-82-4. Apart from the compound(19481-82-4), you can read my other articles to know other related compounds.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI