Formula: C14H11N3O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Benzyl-5-nitro-1H-indazole, is researched, Molecular C14H11N3O2, CAS is 23856-20-4, about Relation between structure and the antiinflammatory and analgesic activities of some aminoindazole derivatives. Author is Granger, Robert; Koeberle, J.; Le-Hao-Dong; Boucard, M.; Giroux, J. J.; Mizoule, J.; Yavordios, D..
Of the 12 aminoindazole derivatives studied, the 5-aminoindazoles had the highest antiinflammatory activity in rats with induced edema, and analgesic activity in mice. 1-Benzoyl-5-aminoindazole-HCl, the most interesting of the compounds studied, had a 50% effective dose of 100 mg/kg and 125 mg/kg in rats with Carrageenin-induced edema and kaolin-induced edema, resp. The hydrochloride (100 mg/kg/day, for 11 days) inhibited in vivo granuloma growth by 32%. In the rat, the antipyretic activity was equal to ∼40% of the activity obtained with an equal dose of acetylsalicyclic acid.
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