In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Two new Cu(II) complexes based on 5-fluorouracil-1-yl acetic acid and N-donor ligands: Investigation of their interaction with DNA and anticancer activity, published in 2022-01-31, which mentions a compound: 15418-29-8, mainly applied to copper fluorouracilyl acetate diimine complex preparation DNA interaction; antitumor activity copper fluorouracilyl acetate diimine complex; crystal structure copper fluorouracilyl acetate diimine complex, Application In Synthesis of Copper(I) tetra(acetonitrile) tetrafluoroborate.
Two new Cu(II) complexes [Cu(bpy)2L1] BF4·CH3OH (Z3) and [Cu (phen)2L1] BF4·H2O (Z = 9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2′-Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines studied. The complexes were characterized by IR spectra, elemental anal., and x-ray crystallog. The interaction of the complexes with CT-DNA was studied by UV-visible absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC50 amount of 11.31 ± 0.74μM for Z = 9. The nature of the nitrogen-donor ligand is very effective in the anticancer activity of the complexes.
There is still a lot of research devoted to this compound(SMILES：[Cu+](N#CC)(N#CC)(N#CC)N#CC.[B+3]([F-])([F-])([F-])[F-])Application In Synthesis of Copper(I) tetra(acetonitrile) tetrafluoroborate, and with the development of science, more effects of this compound(15418-29-8) can be discovered.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI