Formula: C7H3ClN2O2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Chloro-6-nitrobenzo[d]thiazole, is researched, Molecular C7H3ClN2O2S, CAS is 2407-11-6, about Luciferin Derivatives for Enhanced in Vitro and in Vivo Bioluminescence Assays. Author is Shinde, Rajesh; Perkins, Julie; Contag, Christopher H..
In vivo bioluminescence imaging has become a cornerstone technol. for preclin. mol. imaging. This imaging method is based on light-emitting enzymes, luciferases, which require specific substrates for light production When linked to a specific biol. process in an animal model of human biol. or disease, the enzyme-substrate interactions become biol. indicators that can be studied noninvasively in living animals. Signal intensity in these animal models depends on the availability of the substrate for the reaction within living cells in intact organs. The biodistribution and clearance rates of the substrates are therefore directly related to optimal imaging times and signal intensities and ultimately determine the sensitivity of detection and predictability of the model. Modifications of D-luciferin, the substrate for the luciferases obtained from beetle, including fireflies, result in novel properties and offer opportunities for improved bioassays. For this purpose, the authors have synthesized a conjugate, glycine-D-aminoluciferin, and investigated its properties relative to those of D-aminoluciferin and D-luciferin. The three substrates exhibited different kinetic properties and different intracellular accumulation profiles due to differences in their mol. structure, which in turn influenced their biodistribution in animals. Glycine-D-aminoluciferin had a longer in vivo circulation time than the other two substrates. The ability to assay luciferase in vitro and in vivo using these substrates, which exhibit different pharmacokinetic and pharmacodynamic properties, will provide flexibility and improve current imaging capabilities.
There is still a lot of research devoted to this compound(SMILES：O=[N+](C1=CC=C2N=C(Cl)SC2=C1)[O-])Formula: C7H3ClN2O2S, and with the development of science, more effects of this compound(2407-11-6) can be discovered.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI