In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Pharmacological management of dementia with Lewy bodies with a focus on zonisamide for treating parkinsonism, published in 2021, which mentions a compound: 271-95-4, Name is 1,2-Benzisoxazole, Molecular C7H5NO, COA of Formula: C7H5NO.
A review. Dementia with Lewy bodies (DLB) has no approved symptomatic or disease-modifying treatments in the US and Europe, despite being the second most common cause of neurodegenerative dementia. Herein, the authors briefly review the DLB drug development pipeline, providing a summary of the current pharmacol. intervention studies. They then focus on the anticonvulsant zonisamide, a benzisoxazole derivative with a sulfonamide group and look at its value for treating parkinsonism in DLB. Several new compounds are being tested in DLB, the most innovative being those aimed at decreasing brain accumulation of α-synuclein. Unfortunately, new drug testing is challenging in terms of consistent diagnostic criteria and lack of reliable biomarkers. Few randomized controlled trials (RCTs) are well-designed, with enough power to detect significant drug effects. Levodopa monotherapy can treat the parkinsonism in DLB, but it can cause agitation or visual hallucination worsening. Two Phase II/III RCTs of DLB patients recently reported a statistically significant improvement in motor function in those receiving zonisamide as an adjunctive treatment to levodopa. New biomarker strategies and validated outcome measures for DLB or prodromal DLB may enhance clin. trial design for the development of specific disease-modifying treatments.
In some applications, this compound(271-95-4)COA of Formula: C7H5NO is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI