In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Activity of benzothiazoles and chemical derivatives on Plasmodium falciparum, published in 2004-11-30, which mentions a compound: 2407-11-6, mainly applied to benzothiazole plasmodium falciparum QSAR antimalarial, Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole.
Malaria is a major health concern particularly in Africa which has about 90% of the worldwide annual clin. cases. The increasing number of drug-resistant Plasmodium falciparum justifies the search for new drugs in this field. Antimalarial activity of 2-substituted 6-nitro- and 6-amino-benzothiazoles and their anthranilic acids has been tested. An in vitro study has been performed on W2 and 3D7 strains of P. falciparum and on clin. isolates from malaria-infected patients. Toxicity has been assessed on THP1 human monocytic cells. For the most active drug candidates, the in vitro study was followed by in vivo assays on P. berghei-infected mice and by in vitro assays in order to determine the stage-dependency and the mechanism of action. Of 39 derivatives tested in vitro, 2 had specific antimalarial properties. Each compound was active on all stages of the parasite, but one was markedly active on mature schizonts, while the other was more active on young schizont forms. Both drugs were also active on mitochondrial membrane potential. In vivo data confirmed efficiency with a sustained decrease of parasitemia. Products A12 and C7 may be considered as potential antimalarial worthy of further chem. and biol. research.
In some applications, this compound(2407-11-6)Quality Control of 2-Chloro-6-nitrobenzo[d]thiazole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI