Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,2-Benzisoxazole, is researched, Molecular C7H5NO, CAS is 271-95-4, about Albumin-Catalyzed Proton Transfer.Reference of 1,2-Benzisoxazole.
Bovine serum albumin (BSA) catalyzes the decomposition of substituted benzisoxazoles with surprising efficiency. The pH-rate profile and chem. modification data suggest that a lysine residue acts as a catalytic base, so this protein serves as a valuable counterpart to a previously described antibody catalyst for the same reaction which has a reactive carboxylate residue. The kcat and kcat/Km values are similar in magnitude for both catalysts at their pH optima, although comparison with relevant model system indicates that the antibody carboxylate functions more effectively given its pKa than the intrinsically more reactive primary amine of BSA. The relative catalytic efficiencies of BSA and antibody are discussed in terms of known functionalities at their resp. active sites.
In some applications, this compound(271-95-4)Reference of 1,2-Benzisoxazole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI