Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Tris(2,2′-bipyridine)ruthenium bis(hexafluorophosphate), is researched, Molecular C30H24F12N6P2Ru, CAS is 60804-74-2, about Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3]2+ Core.Related Products of 60804-74-2.
Complementary to classical treatment methods used against cancer, photodynamic therapy (PDT) has received increasing attention over the last years. PDT relies on the generation of reactive oxygen species (ROS) upon light irradiation to trigger cell death. As the wavelength employed during such treatments directly influences the light penetration depth and therefore the possibility to treat deep seated tumors or large tumors, research efforts have been made towards the development of photosensitizers (PSs) with an absorption in the phototherapeutic window (600-900 nm). To tackle this drawback, we report herein the preparation and characterization of new RuII-containing PDT PSs, that are based on a [Ru(bipy)3]2+ core (1; bipy: 2,2′-bipyridine) and that are extended with Me groups (2) or vinyl dimethylamino groups (3). As anticipated with our design, we found a red-shift of 65 nm of the maximum absorption of complex 3 in comparison to complex 1. In addition, we report on the in-depth photophys. properties as well as (photo-)cytotoxicity against cervical cancerous HeLa cells of the investigated compounds
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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI