Formula: C12H12Cl4Ru2, Why do aromatic interactions matter?In this blog, let’s explore why it’s so important to understand aromatic interactions using 37366-09-9 as examples. 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2. In a Article，once mentioned of 37366-09-9
A series of arene Ru(II) salt complexes of the type [(eta6-arene)RuCl(eta2-dppm)]+[ECl3]- (arene = C6H6, p-cymene, 1,3,5-Me3C6H3; E = Ge, Sn) bearing trichlorogermanate and trichlorostannate anions are reported. Starting from the known complexes: [(eta6-C6H6)RuCl2(eta1-dppm)] (1), [(eta6-p-cymene)RuCl2(eta1-dppm)] (3) and the novel complex [(eta6-1,3,5-Me3C6H3)RuCl2(eta1-dppm)] (7) (dppm = 1,1-bis(diphenylphosphino)methane), reactions with SnCl2 or GeCl2(dioxane) respectively afforded, by halide abstraction at the ruthenium(II) centres in 1, 3 or 7 the salts: [(eta6-C6H6)RuCl(eta2-dppm)]+ SnCl3? (2), [(eta6-p-cymene)RuCl(eta2-dppm)]+ SnCl3? (4), [(eta6-C6H6)RuCl(eta2-dppm)]+ GeCl3? (5), [(eta6-p-cymene)RuCl(eta2-dppm)]+ GeCl3? (6), [(eta6-1,3,5-Me3C6H3)RuCl(eta2-dppm)]+ SnCl3? (8) and [(eta6-1,3,5-Me3C6H3)RuCl(eta2-dppm)]+ GeCl3? (9). The trichlorostannate complexes 2, 4 and 8 are extremely rare examples of ruthenium complexes bearing the SnCl3? counter anion, and the complexes 5, 6 and 9 are the first examples of ruthenium trichlorogermanate complexes to be reported. All compounds were isolated in high yields as air stable materials and were spectroscopically characterized by multinuclear NMR: (1H, 31P{1H}, 13C{1H}), Infra-red (IR), UV?Vis, and high resolution electrospray ionization mass spectrometry (HR-ESI-MS), the latter both in (+) and (?) mode. Additionally, single crystal X-ray diffraction analyses of salts 4 and 6 are reported, revealing pseudotetrahedral Ru(II) centres with eta6 bound p-cymene ligands and eta2-bound dppm ligands with statistical disorder on the ECl3- anions (E = Ge (6), Sn (4)). Density functional theory calculations (B3LYP with the basis set 6-31 + G(d,p) for H, C, P and Cl atoms; while for Ru, Ge, and Sn atoms DGDZVP basis set) are reported for salts 4 and 6 revealing localization of the LUMOs on the ruthenium-arene rings and some localization on the chloride atom. Finally, MTT in vitro cytotoxicity assays for the MCF-7 and MDA-MB-231 breast cancer cell lines are reported for all complexes and compared to cisplatin. All complexes show remarkable in vitro cytotoxic activity and most are considerably more cytotoxic than cisplatin in both breast cancer cell lines: IC50 values range from 2.25 muM (compound 2) to 5.97 muM (compound 9) (cisplatin = 5.74 muM) in MCF-7 cells; 2.20 muM (compound 2) to 6.39 muM (compound 5) (cisplatin = 13.98 muM) in MDA-MB-231. Moreover, when compared to non-malignant breast epithelial cells (MCF12A), all complexes exhibit promising selectivity indices (SI) with compound 5 having the highest SI in MCF-7 cells at 4.8; and compound 6 at 3.65 in MDA-MB-231, with most of the other compounds also being considerably more selective than cisplatin on both cell-lines (SI = 2.26 on MCF-7 and 0.93 on MDA-MB-231). A clonogenic assay was conducted for salts 5 and 6 and the results reveal that both compounds inhibited long-term (14 days) survival in both breast cancer cell lines tested indicating these drugs are very promising candidates for pre-clinical studies.
Learn more about the 37366-09-9., Formula: C12H12Cl4Ru2
Reference：
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI