Electric Literature of 10049-08-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 10049-08-8, Name is Ruthenium(III) chloride
GdIII-containing metallostar contrast agents are gaining increased attention, because their architecture allows for a slower tumbling rate, which, in turn, results in larger relaxivities. So far, these metallostars find possible applications as blood pool contrast agents. In this work, the first example of a tissue-selective metallostar contrast agent is described. This RGD-peptide decorated RuII(GdIII) 3metallostar is synthesized as an alphavbeta 3-integrin specific contrast agent, with possible applications in the detection of atherosclerotic plaques and tumor angiogenesis. The contrast agent showed a relaxivity of 9.65 s-1 mM-1, which represents an increase of 170%, compared to a low-molecular-weight analogue, because of a decreased tumbling rate (tauR = 470 ps). The presence of the MLCT band (absorption 375-500 nm, emission 525-850 nm) of the central Ru II(Ph-Phen)3-based complex grants the metallostar attractive luminescent properties. The 3MLCT emission is characterized by a quantum yield of 4.69% and a lifetime of 804 ns, which makes it an interesting candidate for time-gated luminescence imaging. The potential application as a selective MRI contrast agent for alphavbeta 3-integrin expressing tissues is shown by an in vitro relaxometric analysis, as well as an in vitroT1-weighted MR image.
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI