Electric Literature of 246047-72-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 246047-72-3, Name is (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium. In a document type is Article, introducing its new discovery.
The dramatic reactivity difference between the Grubbs metathesis catalysts and their resting-state methylidene derivatives was probed in an integrated crystallographic, solid-state NMR and localized molecular orbital analysis study. A principal focus was the second-generation Grubbs system RuCl2(H2IMes)(PCy3)(=CHR) (GII, R = Ph; GIIm, R = H); supporting studies were carried out with the first-generation species RuCl2(PCy3)2(=CHR) (GI, GIm). The compiled rate constants for PCy3 dissociation demonstrate the limited lability of the methylidene complexes (e.g., ca. 275-fold lower for GIIm than GII and nearly 2000 times lower for the IMes analogue GIIm?). This is important because it impedes catalyst re-entry from the resting state into the active cycle. The 31P chemical shift (CS) tensors for the PCy3 ligand exhibited the expected changes (i.e., those characteristic of an increased Ru-P orbital interaction) in GIIm relative to GII, as did GIm vs GI. Greater insight was offered by the 13C CS tensors. Whereas calculations on truncated models predict significant differences in 13C CS tensor values for GII compared with GIIm, the experimental values are equivalent, implying a compensating effect that weakens the Ru=C interaction in the benzylidene complex. Published X-ray crystallographic parameters for GII and GI reveal that one chloride ligand is displaced below the basal plane by steric interactions with the benzylidene phenyl group, an effect absent in GIIm and GIm. During PCy3 loss from the [Ru]=CHPh systems, established processes of alkylidene rotation transform Ph-Cl repulsion into Ph-PCy3 repulsion. Displacing the PCy3 ligand below the plane does not relieve this conflict, instead incurring steric interactions with the H2IMes ligand. Enhanced PCy3 lability in the benzylidene complexes, relative to their methylidene analogues, is hence proposed to originate in the steric pressure exerted by the Ph substituent.
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Reference：
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI