Synthetic Route of 15746-57-3, An article , which mentions 15746-57-3, molecular formula is C20H16Cl2N4Ru. The compound – Cis-Dichlorobis(2,2′-bipyridine)ruthenium(II) played an important role in people’s production and life.
A new Ru(II) bipyridyl complex with O4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spec-trometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cyto-toxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were > 300 and 177.63±2.28 muM for the A549 and K562 cells, respectively.
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Reference：
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI