37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer, molecular formula is C12H12Cl4Ru2, belongs to ruthenium-catalysts compound, is a common compound. In a patnet, once mentioned the new application about 37366-09-9, Formula: C12H12Cl4Ru2
A series of arene ruthenium(ii) complexes coordinated by phenanthroimidazole derivatives have been synthesized and evaluated for their in vitro anticancer activities. It has been found that these types of arene Ru(ii) complexes, especially [(C6H6)Ru(o-ClPIP)Cl] Cl·2H2O (2a), exhibited acceptable antiproliferative activity against several human cancer cell lines but with low toxicity towards normal HK-2 human cells. Mechanistic studies revealed that 2a-induced growth inhibition against osteosarcoma MG-63 cells was mainly caused by S-phase cell cycle arrest, which was confirmed by the down-regulation of cyclin A and CDK2 using western blot analysis of protein levels. Furthermore, studies using comet assay at single cell level indicated that 2a triggered DNA damage in MG-63 cells, and subsequently initiated S-phase arrest, as shown by the up-regulation of phosphorylated p53 and histone. Moreover, exposure of MG-63 cells to 2a resulted in the down-regulation of c-Myc protein expression. The in vitro DNA-binding behaviors also indicated that 2a could stabilize c-Myc G-quadruplex DNA (G4-DNA) by affecting its conformation. In conclusion, these results suggest that arene Ru(ii) complexes coordinated by phenanthroimidazole derivatives serve as c-Myc G4-DNA stabilizers that could induce S-phase arrest in cancer cells by triggering DNA damage, which suggest that these complexes may act as potential candidates for the treatment of human malignant osteosarcoma. This journal is the Partner Organisations 2014.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: Dichloro(benzene)ruthenium(II) dimer. In my other articles, you can also check out more blogs about 37366-09-9
Reference：
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI