In an article, published in an article, once mentioned the application of 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer,molecular formula is C12H12Cl4Ru2, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 37366-09-9
Half-sandwich ruthenium, rhodium and iridium complexes (1?12) were synthesized with aldoxime (L1), ketoxime (L2) and amidoxime (L3) ligands. Ligands have the general formula [PyC(R)NOH], where R = H (L1), R = CH3 (L2) and R = NH2 (L3). Reaction of [{(arene)MCl2}2] (arene = p-cymene, benzene, Cp*; M = Ru, Rh, Ir) with ligands L1?L3 in 1:2 metal precursor-to-ligand ratio yielded complexes such as [{(arene)MLkappa2 (N?N)Cl}]PF6. All the ligands act as bidentate chelating nitrogen donors in kappa2 (N?N) fashion while forming complexes. In vitro anti-tumour activity of complexes 2 and 10 against HT-29 (human colorectal cancer), BE (human colorectal cancer) and MIA PaCa-2 (human pancreatic cancer) cell lines and non-cancer cell line ARPE-19 (human retinal epithelial cells) revealed a comparable activity although complex 2 demonstrated greater selectivity for MIA PaCa-2 cells than cisplatin. Further studies demonstrated that complexes 3, 6, 9 and 12 induced significant apoptosis in Dalton’s ascites lymphoma (DL) cells. In vivo anti-tumour activity of complex 2 on DL-bearing mice revealed a statistically significant anti-tumour activity (P = 0.0052). Complexes 1?12 exhibit HOMO?LUMO energy gaps from 3.31 to 3.68 eV. Time-dependent density functional theory calculations explain the nature of electronic transitions and were in good agreement with experiments.
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Reference：
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI