Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 15746-57-3, C20H16Cl2N4Ru. A document type is Article, introducing its new discovery., Formula: C20H16Cl2N4Ru
The purpose of the present investigation was to ascertain whether 3IL excited states with microsecond lifetimes are universally potent for photodynamic applications, and if these long-lived states are superior to their 3MLCT counterparts as in vitro PDT agents. A family of blue-green absorbing, Ru(II)-based transition metal complexes derived from the pi-expansive dppn ligand was prepared and characterized according to its photodynamic activity against HL-60 cells, and toward DNA in cell-free media. Complexes in this series that are characterized by low-energy and long-lived 3IL excited states photocleaved DNA with blue, green, red, and near-IR light. This panchromatic photodynamic effect translated to in vitro multiwavelength photodynamic therapy (PDT) with red-light cytotoxicities as low as 1.5 muM (EC50) for the parent complex and 400 nM for its more lipophilic counterpart. This potency is similar to that achieved with Ru(II)-based dyads containing long-lived 3IL excitons located on appended pyrenyl units, and appears to be a general property of sufficiently long-lived excited states. Moreover, the red PDT observed for certain members of this family was almost 5 times more potent than Photofrin with therapeutic indices 30 times greater. Related Ru(II) complexes having lowest-lying 3MLCT states of much shorter duration (?1 mus) did not yield DNA photodamage or in vitro PDT with red or near-IR light, nor did the corresponding Os(II) complex with a submicrosecond 3IL excited state lifetime. Therefore, metal complexes that utilize highly photosensitizing 3IL excited states, with suitably long lifetimes (? 1 mus), are well-poised to elicit PDT at wavelengths even where their molar extinction coefficients are very low (<100 M-1 cm-1). Herein we demonstrate that such unexpected reactivity gives rise to very effective PDT in the typical therapeutic window (600-850 nm). Interested yet? Keep reading other articles of 15746-57-3!, Formula: C20H16Cl2N4Ru
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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI