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The invention relates to a process for preparing a with anti-tumor activity of ruthenium ligand and its preparation and use, in ruthenium complex is introduced in through HIF – 1 alpha inhibitors YC – 1, can have biological activity of ruthenium (II) and HIF – 1 alpha inhibitors YC – 1 at the same time delivery to hypoxic tumor cells, to hope that through various mechanisms to demonstrate its anti-cancer activity, thereby improving the therapeutic effect of the chemotherapeutics; through the cytotoxic activity study indicates that such aromatic – ruthenium complex has better anti-tumor activity, especially for the hypoxic tumor cells is significantly better than normoxia tumor cell cytotoxicity, in such aromatic – ruthenium complex design and produce the efficacy of the ligand as a key intermediate in the process of play a crucial role. (by machine translation)
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Reference:
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI