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Aminocyclohexane derivatives as 5-HT receptor agonists

A class of substituted aminocyclohexane derivatives are selective agonists of 5-HT 1 -like receptors, being potent agonists of the human 5-HT 1D alpha receptor subtype while possessing at least a 10-fold selective affinity for the 5-HT 1D alpha receptor subtype relative to the 5-HT 1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT 1D receptors is indicated, while eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT 1D receptor agonists.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI