Day: March 16, 2021

Synthetic Route of 37366-09-9. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 37366-09-9, Name is Dichloro(benzene)ruthenium(II) dimer. In a document type is Article, introducing its new discovery.

Novel microwave synthesis of half-sandwich [(eta6-C 6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity

We have used a novel microwave-assisted method to synthesize a pair of half-sandwich ruthenium-arene-thiosemicarbazone complexes of the type [(eta6-C6H6Ru(TSC)Cl]PF6. The thiosemicarbazone (TSC) ligands are 2-(anthracen-9-ylmethylene) hydrazinecarbothioamide and 2-(anthracen-9-ylmethylene)-N- ethylhydrazinecarbothioamide derived from 9-anthraldehyde. The complexes are moderately strong binders of DNA, with binding constants of 104 m-1. They are also strong binders of human serum albumin, having binding constants of the order of 105 m-1. The complexes show some in vitro anticancer activity against human colon cancer cells, Caco-2 and HCT-116, with positive therapeutic indices. They did not show any activity as antibacterial agents against the organisms that were studied. Copyright

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Related Products of 32993-05-8. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 32993-05-8, Name is Chlorocyclopentadienylbis(triphenylphosphine)ruthenium(II). In a document type is Article, introducing its new discovery.

Ruthenium hydride complexes of chiral and achiral diphosphazane ligands and asymmetric transfer hydrogenation reactions

The half-sandwhich ruthenium chloro complexes bearing chelated diphosphazane ligands, [(eta5-Cp)RuCl{kappa2-P,P-(RO)2PN(M e)P(OR)2}] [R = C6H3Me2-2,6] (1) and [(eta5-Cp*)RuCl{kappa2- P,P-X2PN(R)PYY?}] [R = Me, X = Y = Y? = OC6H5 (2); R = CHMe2, X2 = C20H12O2, Y = Y? = OC6H5 (3) or OC6H4tBu-4 (4)] have been prepared by the reaction of CpRu(PPh3)2Cl with (RO)2PN(Me)P(OR)2 [R = C6H3Me2-2,6 (L1)] or by the reaction of [Cp*RuCl2]n with X2PN(R)PYY? in the presence of zinc dust. Among the four diastereomers (two enantiomeric pairs) possible for the “chiral at metal” complexes 3 and 4, only two diastereomers (one enantiomeric pair) are formed in these reactions. The complexes 1, 2, 4 and [(eta5-Cp)RuCl{kappa2-P,P-Ph2PN((S) -*CHMePh)PPhY}] [Y = Ph (5) or N2C3HMe2-3,5 (SCSPRRu)-(6)] react with NaOMe to give the corresponding hydride complexes [(eta5-Cp)RuH{kappa2-P,P-(RO)2PN(Me )P(OR)2}] (7), [(eta5-Cp*)RuH{kappa2-P, P?-X2PN(R)PY2}] [R = Me, X = Y = OC6H5 (8); R = CHMe2, X2 = C20H12O2, Y = OC6H4tBu-4 (9)] and [(eta5-Cp)RuH{kappa2-P,P-Ph2PN((S)- *CHMePh)PPhY}][Y = Ph (10) or N2C3HMe2-3,5 (SCSPRRu)-(11a) and (SCSPSRu)-(11b)]. Only one enantiomeric pair of the hydride 9 is obtained from the chloro precursor 4 that bears sterically bulky substituents at the phosphorus centers. On the other hand, the optically pure trichiral complex 6 that bears sterically less bulky substituents at the phosphorus gives a mixture of two diastereomers (11a and 11b). Protonation of complex 7 using different acids (HX) gives a mixture of [(eta5-Cp)Ru(eta2-H2){kappa 2-P,P-(RO)2PN(Me)P(OR)2}]X (12a) and [(eta5-Cp)Ru(H)2{kappa2-P,P-(RO) 2PN(Me)P(OR)2}]X (12b) of which 12a is the major product independent of the acid used; the dihydrogen nature of 12a is established by T1 measurements and also by synthesizing the deuteride analogue 7-D followed by protonation to obtain the D-H isotopomer. Preliminary investigations on asymmetric transfer hydrogenation of 2-acetonaphthone in the presence of a series of chiral diphosphazane ligands show that diphosphazanes in which the phosphorus centers are strong pi-acceptor in character and bear sterically bulky substituents impart moderate levels of enantioselectivity. Attempts to identify the hydride intermediate involved in the asymmetric transfer hydrogenation by a model reaction suggests that a complex of the type, [Ru(H)(Cl){kappa2-P,P-X2PN(R)PY2}(sol vent)2] could be the active species in this transformation.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

32993-05-8, Name is Chlorocyclopentadienylbis(triphenylphosphine)ruthenium(II), molecular formula is C41H35ClP2Ru, belongs to ruthenium-catalysts compound, is a common compound. In a patnet, once mentioned the new application about 32993-05-8, category: ruthenium-catalysts

Preparation of diazoalkane complexes of ruthenium and their cyclization reactions with alkenes and alkynes

The diazoalkane complexes [Ru(eta5-C5H 5)(N2CAr1Ar2)(PPh3)(L)]BPh4 (1-5: Ar1 = Ar2 = Ph (a), Ar1 = Ph and Ar2 = p-tolyl (b), Ar1Ar2 = C 12H8 (c), Ar1 = Ph and Ar2 = PhCO (d); L = PPh3 (1), P(OMe)3 (2), P(OEt)3 (3), PPh(OEt)2 (4), ButNC (5)) were prepared by allowing the chloro compounds RuCl(eta5-C5H5)(PPh3)(L) to react with the diazoalkanes Ar1Ar2CN2 in ethanol. Treatment of complexes 1-5 with ethylene (CH2=CH2) under mild conditions (1 atm, room temperature) led not only to the eta2-ethylene complexes [Ru(eta5-C5H5)(eta2-CH 2=CH2)(PPh3)(L)]BPh4 (10-14) but also to dipolar (3 + 2) cycloaddition, affording the 4,5-dihydro-3H-pyrazole derivatives [Ru(eta5-C5H5){eta1- N=NC(Ar1Ar2)CH2CH2}(PPh3)(L)]BPh4 (6-9). Acrylonitrile (CH2=C(H)CN) reacted with diazoalkane complexes 2 and 3 to give the 1H-pyrazoline derivatives [Ru(eta5-C 5H5){eta1-N=C(CN)CH2C(Ar1Ar2)NH} (PPh3)(L)]BPh4 (19, 20). However, reactions with propylene (CH2=C(H)CH3), maleic anhydride (ma, CH=CHCO(O)CO) and dimethyl maleate (dmm, CH3OCOCH=CHOCOCH3) led to the eta2-alkene complexes [Ru(eta5-C5H 5)(eta2-R1CH=CHR2)(PPh3)(L)]BPh4 (17-22). Treatment of the diazoalkane complexes 1 and 2 with acetylene CH?CH under mild conditions (1 atm, room temperature) led to dipolar cycloaddition, affording the 3H-pyrazole complexes [Ru(eta5-C 5H5){eta1-N=NC(Ar1Ar2)CH=CH}(PPh 3){P(OMe)3}]BPh4 (24), whereas reactions with the terminal alkynes PhC?CH and ButC?CH gave the vinylidene derivatives [Ru(eta5-C5H5){=C=C(H) R}(PPh3){P(OMe)3}]BPh4 (25, 26). The alkyl propiolates HC?CCOOR1 (R1 = Me, Et) also reacted with complexes 2 to give the 3H-pyrazole complexes [Ru(eta5-C5H 5){eta1-N=NC(Ar1Ar2)C(COOR1)=CH}(PPh3){P(OMe) 3}]BPh4 (27, 28). The complexes were characterized by spectroscopy and by X-ray crystal structure determinations of [Ru(eta5-C5H5){eta1-N=C(CN) CH2C(Ph)(p-tolyl)NH}(PPh3){P(OMe)3}]BPh 4 (19b), [Ru(eta5-C5H5) {eta2-CH=CHCO(O)CO}(PPh3){P(OMe)3}]BPh 4 (21), and [Ru(eta5-C5H5) {eta1-N=NC(C12H8)CH=CH}(PPh 3){P(OMe)3}]BPh4 (24c).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: ruthenium-catalysts. In my other articles, you can also check out more blogs about 32993-05-8

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 246047-72-3, C46H65Cl2N2PRu. A document type is Article, introducing its new discovery., Application In Synthesis of (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium

Synthesis and high-resolution NMR structure of a beta3- octapeptide with and without a tether introduced by olefin metathesis

Bridging between (i)- and (i+3)-positions in a beta3-peptide with a tether of appropriate length is expected to prevent the corresponding 314-helix from unfolding (Fig. 1). The beta3-peptide H-beta3hVal-beta3hLys-beta3hSer(All) -beta3hPhe-beta3hGlu-beta3hSer(All) -beta3hTyr-beta3hIle-OH (1; with allylated betahSer residues in 3-and 6-position), and three tethered beta-peptides 2 – 4 (related to 1 through ring-closing metathesis) have been synthesized (solid-phase coupling, Fmoc strategy, on chlorotrityl resin; Scheme). A comparative CD analysis of the tethered beta-peptide 4 and its non-tethered analogue 1 suggests that helical propensity is significantly enhanced (threefold CD intensity) by a (CH2)4 linker between the beta3hSer side chains (Fig. 2). This conclusion is based on the premise that the intensity of the negative Cotton effect near 215 nm in the CD spectra of beta3-peptides represents a measure of ‘helical content’. An NMR analysis in CD3OH of the two beta3- octapeptide derivatives without (i.e., 1) and with tether (i.e., 4; Tables 1 – 6, and Figs. 4 and 5) provided structures of a degree of precision (by including the complete set of side chainside chain and side chain – backbone NOEs) which is unrivaled in beta-peptide NMR-solution-structure determination. Comparison of the two structures (Fig. 5) reveals small differences in side-chain arrangements (separate bundles of the ten lowest-energy structures of 1 and 4, Fig. 5, A and B) with little deviation between the two backbones (superposition of all structures of 1 and 4, Fig. 5, C). Thus, the incorporation of a CH 2-O-(CH2)4-O-CH2 linker between the backbone of the beta3-amino acids in 3-and 6-position (as in 4) does accurately constrain the peptide into a 314-helix. The NMR analysis, however, does not suggest an increase in the population of a 3 14-helical backbone conformation by this linkage. Possible reasons for the discrepancy between the conclusion from the CD spectra and from the NMR analysis are discussed.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Reference of 246047-72-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 246047-72-3, C46H65Cl2N2PRu. A document type is Article, introducing its new discovery.

Dynamic Memory Effects in the Mechanochemistry of Cyclic Polymers

Cyclic polymers containing multiple gem-dichlorocyclopropane (gDCC) mechanophores along their backbone were prepared using ring expansion metathesis polymerization. The mechanochemistry of the cyclic polymers was investigated using pulsed ultrasonication. The fraction of gDCC mechanophores that are activated per chain halving event (phi) was compared to that of linear analogs. For 167 kDa cyclic polymer, phi = 0.38, vs phi = 0.62 for 158 kDa linear polymers analogs, even though cyclic chain fragmentation necessarily proceeds through a linear intermediate of comparable composition to the initially linear systems. Ozonolysis of the mechanochemical products further shows that the mechanochemical “activation zone” in the cyclic polymer is less continuous than in the linear polymer. These results suggest that the linear intermediate in cyclic polymer fragmentation undergoes subsequent scission during the same high strain rate extensional event in which it is formed and furthermore retains at least a partial memory of its original cyclic conformation at the time of fragmentation.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Related Products of 246047-72-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 246047-72-3, Name is (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, molecular formula is C46H65Cl2N2PRu. In a Article£¬once mentioned of 246047-72-3

A new route to vitamin E Key-intermediates by olefin cross-metathesis

Ru-Catalyzed olefin cross-metathesis (CM) has been successfully applied to the synthesis of several phytyl derivatives (2b, 2d-f, 3b) with a trisubstituted C=C bond, as useful intermediates for an alternative route to alpha-tocopheryl acetate (vitamin E acetate; 1b) (Scheme 1). Using the second-generation Grubbs catalyst RuCl2(C21H 26N2)(CHPh)PCy3, (Cy = cyclohexyl; 4a) and Hoveyda-Grubbs catalyst RuCl2(C21H26N 2){CH-C6H4(O-iPr)-2} (4b), the reactions were performed with various C-allyl (5a-f, 7a,b) and O-allyl (8a-d) derivatives of trimethylhydroquinone-1-acetate as substrates. 2,6,10,14-Tetramethylpentadec-1-ene (6a) and derivatives 6c-e of phytol (6b) as well as phytal (6f) were employed as olefin partners for the CM reactions (Schemes 2 and 5). The vitamin E precursors could be prepared in up to 83% isolated yield as (E/Z)-mixtures.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 246047-72-3 is helpful to your research., Related Products of 246047-72-3

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 15746-57-3, C20H16Cl2N4Ru. A document type is Article, introducing its new discovery., category: ruthenium-catalysts

Nanoscale Metal?Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy

We report the rational design of metal?organic layers (MOLs) that are built from [Hf6O4(OH)4(HCO2)6] secondary building units (SBUs) and Ir[bpy(ppy)2]+- or [Ru(bpy)3]2+-derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy=2,2?-bipyridine, ppy=2-phenylpyridine) and their applications in X-ray-induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2]+ or [Ru(bpy)3]2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X-PDT to afford superb anticancer efficacy.

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Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.15746-57-3, Name is Cis-Dichlorobis(2,2′-bipyridine)ruthenium(II), molecular formula is C20H16Cl2N4Ru. In a Patent£¬once mentioned of 15746-57-3, Product Details of 15746-57-3

Ruthenium-diimine type complex as well as preparation method and application thereof

The invention relates to a ruthenium-diimine type complex as well as a preparation method and application thereof. The method comprises the following steps: i, dissolving 2-pyridine carboxaldehyde and2-aminochrysene into absolute ethyl alcohol, and heating and stirring under the protection of nitrogen gas; adding a ruthenium complex precursor Ru(bpy)2Cl2; heating and refluxing overnight under theprotection of the nitrogen gas; after raw materials are completely transformed, stopping heating; cooling to room temperature and concentrating; adding a methanol saturated solution of ammonium hexafluorophosphate into a concentrated solution; transferring a reaction mixture into a sand plate funnel for suction filtration, and washing; dissolving a crude product into acetone and taking n-hexane as a dispersion agent for recrystallizing, so as to obtain a ruthenium-diimine type complex pure product. The ruthenium-diimine type complex provided by the invention has the advantages of simple preparation method and relatively high yield and purity; after a ligand is synthesized, the ligand does not need to be subjected to separation treatment and can directly react with a ruthenium precursor toobtain a target product. The ruthenium-diimine type coordination complex has a wide application prospect in the fields including catalysis, sensing, molecular recognition and the like.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 15746-57-3, you can also check out more blogs about15746-57-3

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

Reference of 246047-72-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 246047-72-3, C46H65Cl2N2PRu. A document type is Article, introducing its new discovery.

Synthesis of pyrimidine-modified NHC ruthenium-alkylidene catalysts and their application in RCM, CM, em and ROMP reactions

A new type of N-heterocyclic carbene bearing ruthenium olefin metathesis catalyst was prepared through the incorporation of a chelated pyrimidinyl methylene subunit, in which electron-rich substituents were attached to stabilize the ruthenium complexes. These catalysts were successfully used in various types of olefin metathesis reactions, including ring-closing metathesis (RCM), cross-metathesis (CM), enyne metathesis (EM), and ring-opening metathesis polymerization (ROMP) reactions. The results therein showed that the presence of an electron-deficient pyrimidine structure greatly enhanced the new NHC ruthenium complexes’ catalytic activities. New N-heterocyclic carbene bearing ruthenium olefin metathesis catalysts were synthesized and applied in various types of olefin metathesis reactions, including ring-closing metathesis, cross-metathesis, enyne metathesis, and ring-opening metathesis polymerization reactions. Copyright

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 301224-40-8, Name is (1,3-Dimesitylimidazolidin-2-ylidene)(2-isopropoxybenzylidene)ruthenium(VI) chloride, molecular formula is C31H38Cl2N2ORu. In a Article£¬once mentioned of 301224-40-8, HPLC of Formula: C31H38Cl2N2ORu

Lewis-acid assisted cross metathesis of acrylonitrile with functionalized olefins catalyzed by phosphine-free ruthenium carbene complex

The exchange of the PPh3 ligand in the complex [1,3-bis(2,6-dimethylphenyl)4,5-dihydroimidazol-2-ylidene](PPh 3)-(Cl)2Ru=CHPh (7) for a pyridine ligand at ambient temperature leads to the formation of the stable phosphine-free carbene ruthenium complex [1,3-bis(2,6-dimethylphenyl)4,5-dihydroimidazol-2-ylidene] (C5H5N)2(Cl)2 Ru=CHPh (8). The resulted ruthenium complex exhibits highly catalytic activity for the cross metathesis of acrylonitrile with various functionalized olefins under mild conditions, and its activity can be further improved by the addition of a Lewis acid such as Ti(O?Pr)4. In the mixture products, the Z-isomer predominates. The Royal Society of Chemistry 2005.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.HPLC of Formula: C31H38Cl2N2ORu, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 301224-40-8, in my other articles.

Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI