Archives for Chemistry Experiments of 246047-72-3

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Application of 246047-72-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 246047-72-3, Name is (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium

Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol-adenosine hybrids as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1

A series of estradiol (E2) derivatives were designed to interact with, both the substrate- and the cofactor-binding sites of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). These analogues of potent E2-adenosine hybrid inhibitor EM-1745, where the adenosine moiety was replaced by a more stable benzene derivative, were synthesized from estrone using alkene cross-metathesis and Sonogashira coupling reactions as key steps. In vitro biological evaluation of these steroid derivatives revealed that a spacer of 13 methylenes, between the 16beta-position of E2 and the adenosine mimic bearing a carboxylic acid, group, gave the best inhibition of 17beta-HSD1.

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Reference£º
Highly efficient and robust molecular ruthenium catalysts for water oxidation,
Catalysts | Special Issue : Ruthenium Catalysts – MDPI