With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.246047-72-3,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium,as a common compound, the synthetic route is as follows.
To a solution of 6b (31.0 mg, 0.048 mmol) in anhydrous CH2Cl2 (5.0 ml) was added 2ndgeneration Grubbs catalyst (37.0 mg, 0.052 mmol) and CuCl (I) (9.6 mg, 0.097 mmol)under nitrogen at 30 C and stirred for 1 h. The reaction mixture was concentrated invacuo, and the residue was purified by column chromatography on silica gel (hexane /CH2Cl2 = 1 / 1) to give 2f (27.0 mg, 50%).Green crystals; mp 125-127 C (dec.); 1H NMR (270 MHz, CDCl3) delta 1.21 (d, J = 6.4Hz, 6H), 1.27 (d, J = 5.6 Hz, 6H), 2.37 (s, 6H), 2.47 (bs, 12H), 4.19 (s, 4H), 4.51-4.45(m, 1H), 5.89-5.80 (m, 1H), 6.70 (d, J = 1.3 Hz, 1H), 7.06 (s, 4H), 7.18 (d, J = 1.6 Hz,1H), 16.31 (s, 1H); 19F NMR (466 MHz, CDCl3) delta -80.5 (3F), -110.0 (2F), -121.3 (4F),-121.7 (4F), -122.5 (2F), -125.9 (2F); 13C NMR (68 MHz, CDCl3) delta 21.5, 21.9, 22.5,51.3, 75.7, 76.0, 113.7, 114.5, 116.6, 123.5, 125.5, 126.6, 127.5, 129.4, 139.0, 143.5,147.4, 151.2, 209.8, 296.5; IR (FT) 3854, 3738, 3649, 2978, 2931, 2361, 2342, 1481,1199, 1107, 1072, 910, 729 cm-1; HRMS (FAB) m/z [M+H]+ calcd forC42H45Cl2F17N2O2Ru: 1104.1630; found: 1104.1637., 246047-72-3
As the paragraph descriping shows that 246047-72-3 is playing an increasingly important role.
Reference£º
Article; Kobayashi, Yuki; Suzumura, Naoki; Tsuchiya, Yuki; Goto, Machiko; Sugiyama, Yuya; Shioiri, Takayuki; Matsugi, Masato; Synthesis; vol. 49; 8; (2017); p. 1796 – 1807;,
Highly efficient and robust molecular ruthenium catalysts for water oxidation
Catalysts | Special Issue : Ruthenium Catalysts – MDPI